John E. Gadbery
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View article: Tepsin binds LC3B to promote ATG9A trafficking and delivery
Tepsin binds LC3B to promote ATG9A trafficking and delivery Open
Tepsin is an established accessory protein found in Adaptor Protein 4 (AP-4) coated vesicles, but the biological role of tepsin remains unknown. AP-4 vesicles originate at the trans-Golgi network (TGN) and target the delivery of ATG9A, a s…
View article: Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery
Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery Open
Tepsin is an established accessory protein found in Adaptor Protein 4 (AP-4) coated vesicles, but the biological role of tepsin remains unknown. AP-4 vesicles originate at the trans -Golgi network (TGN) and target the delivery of ATG9A, a …
View article: Integrating structural and evolutionary data to interpret variation and pathogenicity in adapter protein complex 4
Integrating structural and evolutionary data to interpret variation and pathogenicity in adapter protein complex 4 Open
Genetic variation in the membrane trafficking adapter protein complex 4 (AP‐4) can result in pathogenic neurological phenotypes including microencephaly, spastic paraplegias, epilepsy, and other developmental defects. We lack molecular mec…
View article: Use of an Isotope-Coded Mass Tag (ICMT) Method To Determine the Orientation of Cholesterol Oxidase on Model Membranes
Use of an Isotope-Coded Mass Tag (ICMT) Method To Determine the Orientation of Cholesterol Oxidase on Model Membranes Open
Although the interfacial membrane protein cholesterol oxidase is structurally and kinetically well-characterized, its orientation in and mode of interaction with cholesterol-containing membranes have not been established. Cholesterol oxida…
View article: Diacyltransferase Activity and Chain Length Specificity of <i>Mycobacterium tuberculosis</i> PapA5 in the Synthesis of Alkyl β-Diol Lipids
Diacyltransferase Activity and Chain Length Specificity of <i>Mycobacterium tuberculosis</i> PapA5 in the Synthesis of Alkyl β-Diol Lipids Open
Although they are classified as Gram-positive bacteria, Corynebacterineae possess an asymmetric outer membrane that imparts structural and thereby physiological similarity to more distantly related Gram-negative bacteria. Like lipopolysacc…