John E. Hall
YOU?
Author Swipe
View article: Neonatal hyperoxia exposure does not exacerbate hypertension programmed by maternal obesity
Neonatal hyperoxia exposure does not exacerbate hypertension programmed by maternal obesity Open
Maternal obesity increases risk for preterm birth and neonatal oxygen exposure. We tested whether hyperoxia (80% O 2 , P3–P10) worsens maternal obesity-induced hypertension. At 14 wk, BP measured by telemetry showed that hyperoxia unexpect…
View article: TRPC6 Deficiency Attenuates Mitochondrial and Cardiac Dysfunction in Heart Failure with Preserved Ejection Fraction Induced by High-Fat Diet Plus L-NAME
TRPC6 Deficiency Attenuates Mitochondrial and Cardiac Dysfunction in Heart Failure with Preserved Ejection Fraction Induced by High-Fat Diet Plus L-NAME Open
Transient receptor potential canonical channel type 6 (TRPC6), a non-selective cation channel that mediates Ca2+ influx, is expressed in the heart and implicated in pathological cardiac hypertrophy. However, the role of TRPC6 in regulating…
View article: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development
Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development Open
Inflammation promotes heart failure (HF) development, and inhibition of IL-12β simultaneously attenuates interleukin-12 (IL-12) and interleukin-23 (IL-23), two important proinflammatory cytokines. In this study, we used IL-12β knockout (KO…
View article: Sex differences in the chronic autoimmune response to myocardial infarction
Sex differences in the chronic autoimmune response to myocardial infarction Open
Myocardial infarction (MI) causes a robust inflammatory response, which is necessary for remodeling and scar formation of the infarcted left ventricle (LV). However, this can lead to chronic systemic inflammation and persistent autoimmune …
View article: Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction
Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction Open
A major new finding of this study is that parental obesity markedly reduces survival rate and exacerbates cardiac dysfunction after myocardial infarction in their offspring, and this effect is independent of offspring sex.
View article: Targeting the Brain Leptin-Melanocortin Pathway to Treat Heart Failure
Targeting the Brain Leptin-Melanocortin Pathway to Treat Heart Failure Open
Purpose of the Review The role of leptin in regulating cardiac function is still controversial with conflicting results in clinical and preclinical studies. However, most previous studies have not considered leptin’s powerful cardiac effec…
View article: Sestrin2 Attenuates Myocardial Endoplasmic Reticulum Stress and Cardiac Dysfunction During Ischemia/Reperfusion Injury
Sestrin2 Attenuates Myocardial Endoplasmic Reticulum Stress and Cardiac Dysfunction During Ischemia/Reperfusion Injury Open
Background Sesn2 (Sestrin2) is a stress‐induced protein that provides protective effects during myocardial ischemia and reperfusion (I/R) injury, while endoplasmic reticulum (ER) stress may be a pivotal mediator of I/R injury. The goal of …
View article: Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury
Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury Open
A major new finding of this study is that chronic activation of leptin receptors in the CNS markedly attenuates acute kidney injury and protects against severe renal dysfunction after ischemia/reperfusion, independently of leptin’s anorexi…
View article: The zero responder: a definition and report of current literature
The zero responder: a definition and report of current literature Open
The term ‘zero responder’ was initially devised in 2010 to describe those passing by or unharmed in a mass casualty incident, who provide life-saving care for injured persons before qualified professionals arrive. This review aims to deter…
View article: Glutamine metabolism improves left ventricular function but not macrophage-mediated inflammation following myocardial infarction
Glutamine metabolism improves left ventricular function but not macrophage-mediated inflammation following myocardial infarction Open
Glutamine metabolism is altered in both infarct macrophages and the remote left ventricle (LV) following myocardial infarction (MI). Supplemental glutamine improves LV function following MI while inhibiting glutamine metabolism with BPTES …
View article: 4D ultrasound‐based strain assessment of cardiac dysfunction in male rats with reperfused and nonreperfused myocardial infarction
4D ultrasound‐based strain assessment of cardiac dysfunction in male rats with reperfused and nonreperfused myocardial infarction Open
Two‐dimensional ultrasound (2DUS) echocardiography is the main noninvasive method used to evaluate cardiac function in animal models of myocardial infarction (MI). However, 2DUS echocardiography does not capture regional differences in car…
View article: Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner
Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner Open
Offspring from obese parents are more susceptible to kidney injury and worse outcomes following an acute ischemia-reperfusion insult. Male, but not female, offspring from obese parents exhibit increased blood pressure early in life. Female…
View article: Abstract 1501 The reduction of adiposity and hepatic lipid accumulation by bilirubin is dependent on its hormonal function
Abstract 1501 The reduction of adiposity and hepatic lipid accumulation by bilirubin is dependent on its hormonal function Open
The global prevalence of obesity and its related comorbidities, including diabetes and metabolic dysfunction associated fatty liver disease (MAFLD), are on the rise. For unknown reasons, serum bilirubin levels are negatively correlated wit…
View article: Mitochondria-derived reactive oxygen species contribute to synergistic interaction of diabetes and hypertension in causing chronic kidney injury
Mitochondria-derived reactive oxygen species contribute to synergistic interaction of diabetes and hypertension in causing chronic kidney injury Open
Our study shows that the combination of diabetes (DM) and hypertension (HTN) promoted renal dysfunction, albuminuria, and mitochondrial dysfunction, whereas DM or HTN alone caused only mild kidney injury. Treatment with the specific mitoch…
View article: Immunometabolism, extracellular vesicles and cardiac injury
Immunometabolism, extracellular vesicles and cardiac injury Open
Recent evidence from our lab and others suggests that metabolic reprogramming of immune cells drives changes in immune cell phenotypes along the inflammatory-to-reparative spectrum and plays a critical role in mediating the inflammatory re…
View article: Strategic philanthropy in a Turkish tourism context
Strategic philanthropy in a Turkish tourism context Open
This paper examines a project called 'Respect to History' which was undertaken by a Turkish oil company. This philanthropic program focused on redeveloping numerous local communities on the Gallipoli peninsula, which were in a state of dis…
View article: Impact of leptin deficiency on male tibia and vertebral body <scp>3D</scp> bone architecture independent of changes in body weight
Impact of leptin deficiency on male tibia and vertebral body <span>3D</span> bone architecture independent of changes in body weight Open
Leptin an adipokine with potent effects on energy balance and body weight plays an important role in defining bone architecture in growing mammals. However, major changes in body weight can also influence morphology of trabecular and corti…
View article: Sex differences in weight gain, blood pressure control, and responses to melanocortin-4 receptor antagonism in offspring from lean and obese parents
Sex differences in weight gain, blood pressure control, and responses to melanocortin-4 receptor antagonism in offspring from lean and obese parents Open
We examined potential sex differences in appetite and blood pressure (BP) responses to melanocortin-4 receptor (MC4R) blockade in offspring from lean and obese parents. Offspring from normal (N) diet-fed parents were fed N (NN) or high-fat…
View article: Temporal changes in glucose metabolism reflect polarization in resident and monocyte-derived macrophages after myocardial infarction
Temporal changes in glucose metabolism reflect polarization in resident and monocyte-derived macrophages after myocardial infarction Open
Introduction Metabolic reprogramming from glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle and oxidative phosphorylation may mediate macrophage polarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. …
View article: Hypothermia Management, an Evaluation of a Novel Lightweight System.
Hypothermia Management, an Evaluation of a Novel Lightweight System. Open
Introduction: Accidental hypothermia remains an important contributory factor to the mortality of trauma patients in both civilian and military environments. As a component of the ‘lethal triad’ it poses a significant problem in patients a…
View article: Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels
Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels Open
Macrophages play critical roles in mediating and resolving tissue injury as well as tissue remodeling during cardiorenal disease. Altered immunometabolism, particularly macrophage metabolism, is a critical underlying mechanism of immune dy…
View article: Long-term consumption of ten food groups and cardiovascular mortality: a systematic review and dose response meta-analysis of prospective cohort studies
Long-term consumption of ten food groups and cardiovascular mortality: a systematic review and dose response meta-analysis of prospective cohort studies Open
Population Medicine considers the following types of articles:• Research Papers -reports of data from original research or secondary dataset analyses.• Review Papers -comprehensive, authoritative, reviews within the journal's scope.These i…
View article: Impact of Diabetes and Hypertension on Left Ventricular Structure and Function: The Jackson Heart Study
Impact of Diabetes and Hypertension on Left Ventricular Structure and Function: The Jackson Heart Study Open
Background Diabetes and hypertension have been associated with adverse left ventricular (LV) remodeling. While they often occur concurrently, their individual effects are understudied. We aimed to assess the independent effects of diabetes…
View article: Long-Term Consumption of 10 Food Groups and Cardiovascular Mortality: A Systematic Review and Dose Response Meta-Analysis of Prospective Cohort Studies
Long-Term Consumption of 10 Food Groups and Cardiovascular Mortality: A Systematic Review and Dose Response Meta-Analysis of Prospective Cohort Studies Open
A large body of evidence exists on diet and cardiovascular mortality, but limited studies have investigated the long-term intake of food groups, which may have cumulative effects on cardiovascular health in the long term. This review there…
View article: Central Nervous System Actions of Leptin Improve Cardiac Function After Ischemia–Reperfusion: Roles of Sympathetic Innervation and Sex Differences
Central Nervous System Actions of Leptin Improve Cardiac Function After Ischemia–Reperfusion: Roles of Sympathetic Innervation and Sex Differences Open
Background Therapeutic strategies for preventing paradoxical reperfusion injury after myocardial ischemia are limited. We tested whether central nervous system actions of leptin induce important protective effects on cardiac function and m…
View article: Direct Cardiac Actions of Sodium-Glucose Cotransporter 2 Inhibition Improve Mitochondrial Function and Attenuate Oxidative Stress in Pressure Overload-Induced Heart Failure
Direct Cardiac Actions of Sodium-Glucose Cotransporter 2 Inhibition Improve Mitochondrial Function and Attenuate Oxidative Stress in Pressure Overload-Induced Heart Failure Open
Clinical trials showed that sodium-glucose cotransporter 2 (SGLT2) inhibitors, a class of drugs developed for treating diabetes mellitus, improve prognosis of patients with heart failure (HF). However, the mechanisms for cardioprotection b…
View article: Transient receptor potential cation channel 6 deficiency leads to increased body weight and metabolic dysfunction
Transient receptor potential cation channel 6 deficiency leads to increased body weight and metabolic dysfunction Open
Transient receptor potential cation channel 6 (TRPC6), a member of the TRPC family, is expressed in the hypothalamus and modulates cell Ca 2+ influx. However, the role of TRPC6 in controlling metabolic and cardiovascular functions under no…