John E. Hearst
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View article: Removal of psoralen monoadducts and crosslinks by human cell free extracts
Removal of psoralen monoadducts and crosslinks by human cell free extracts Open
Human cell free extracts are capable of carrying out damage-induced DNA synthesis in response to DNA damage by UV, psoralen, and cisplatin. We show that this damage-induced DNA synthesis is associated with removal of psoralen adducts and t…
View article: RecA-dependent incision of psoralen-crosslinked DNA by (A)BC excinuclease
RecA-dependent incision of psoralen-crosslinked DNA by (A)BC excinuclease Open
Previous work to elucidate the mechanism of crosslink repair by (A)BC excinuclease has shown that a psoralen-crosslinked duplex is selectively incised in the furan-side strand, while a three-stranded structure is incised in the pyrone-side…
View article: Evidence for structural deformation of the DNA helix by a psoralen diadduct but not by a monoadduct
Evidence for structural deformation of the DNA helix by a psoralen diadduct but not by a monoadduct Open
We have investigated the structural change in a double-stranded DNA helix caused by covalent addition of a psoralen. A synthetic double-stranded DNA was constructed to contain either a psoralen furan-side monoadduct or an interstrand diadd…