John E. Madigan
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View article: Common and atypical presentations of <i>Anaplasma phagocytophilum</i> infection in equids with emphasis on neurologic and muscle disease
Common and atypical presentations of <i>Anaplasma phagocytophilum</i> infection in equids with emphasis on neurologic and muscle disease Open
Background Comprehensive descriptions of equids with granulocytic anaplasmosis (EGA) with neurologic or muscle disease and other atypical presentations are scarce in the literature. Objective Describe the clinical signs, laboratory finding…
Equine Gunshot Euthanasia: Creation of a 3D-Printed Model with Integrated Sensors for Training Open
Challenges and issues related to the use of pentobarbital euthanasia and disposal of animal remains within the US have recently been reviewed. Environmental and public health challenges increasingly necessitate consideration of alternative…
View article: Steroid precursors, steroids, neuroactive steroids, and neurosteroids concentrations in serum and saliva of healthy neonatal heifer Holstein calves
Steroid precursors, steroids, neuroactive steroids, and neurosteroids concentrations in serum and saliva of healthy neonatal heifer Holstein calves Open
Background Persistence of high neurosteroid concentrations in blood is associated with neonatal encephalopathy and septicemia in foals. This has not been investigated in calves. Objectives To determine concentrations of steroid compounds i…
Plasma concentrations of steroid precursors, steroids, neuroactive steroids, and neurosteroids in healthy neonatal foals from birth to 7 days of age Open
Background Transient hypothalamic‐pituitary‐adrenal axis dysfunction occurs in critically ill foals with sepsis and neonatal maladjustment syndrome (NMS). Cortisol is the most commonly measured steroid. However, a complex interaction of va…
Description of Placement Procedures for Common Methods Used in Equine Emergency Rescue Using a Simplified Loops System Open
Entrapped, stranded and recumbent equids often require emergency rescue. The success of the rescue is often affected by secondary injuries from struggling of the horse to rise and from injury secondary to attempted rescue by pulling on the…
Evaluation of a Simplified Loops System for Emergency Rescue Lifting of the Stranded or Recumbent Horse Open
Stranded and recumbent equids often require emergency rescue, and a successful rescue often requires vertical lifting of the animal. Currently, the devices used for vertical lifting of equids are not readily available at an incident or urg…
View article: Effects of magnesium with or without boron on headshaking behavior in horses with trigeminal‐mediated headshaking
Effects of magnesium with or without boron on headshaking behavior in horses with trigeminal‐mediated headshaking Open
Background Oral administration of magnesium and boron might have a beneficial effect on headshaking behavior in horses. Objective Evaluate the effects of oral magnesium alone or in combination with boron on headshaking behavior in affected…
View article: Luteinizing hormone concentrations in healthy horses and horses with trigeminal‐mediated headshaking over an 8‐hour period
Luteinizing hormone concentrations in healthy horses and horses with trigeminal‐mediated headshaking over an 8‐hour period Open
Background Trigeminal‐mediated headshaking results from a low threshold for firing of the trigeminal nerve. A seasonal component has been implicated in onset of clinical signs, which occur during the spring and summer months. Geldings are …
Intravenous infusion of magnesium sulfate and its effect on horses with trigeminal‐mediated headshaking Open
Background Trigeminal‐mediated headshaking results from low‐threshold firing of the trigeminal nerve resulting in apparent facial pain. Magnesium may have neuroprotective effects on nerve firing that potentially dampen signs of neuropathic…
View article: Effect of valacyclovir on EHV‐5 viral kinetics in horses with equine multinodular pulmonary fibrosis
Effect of valacyclovir on EHV‐5 viral kinetics in horses with equine multinodular pulmonary fibrosis Open
Background Equine herpesvirus‐5 is commonly isolated from the lungs of horses with EMPF, suggesting an etiological link. Valacyclovir is used empirically to treat EMPF; however, no data is available concerning its impact on EHV‐5 viral kin…
Alterations in Metabolic Status and Headshaking Behavior Following Intravenous Administration of Hypertonic Solutions in Horses with Trigeminal-Mediated Headshaking Open
Trigeminal-nerve-mediated headshaking represents a major welfare challenge for owners and veterinarians and is caused by a low threshold firing of the trigeminal nerve resulting in pain manifested as violent head jerking that often termina…
<i>Borrelia burgdorferi</i> Infection and Lyme Disease in North American Horses: A Consensus Statement Open
Borrelia burgdorferi infection is common in horses living in Lyme endemic areas and the geographic range for exposure is increasing. Morbidity after B. burgdorferi infection in horses is unknown. Documented, naturally occurring syndromes a…
View article: Survey of Veterinarians Using a Novel Physical Compression Squeeze Procedure in the Management of Neonatal Maladjustment Syndrome in Foals
Survey of Veterinarians Using a Novel Physical Compression Squeeze Procedure in the Management of Neonatal Maladjustment Syndrome in Foals Open
Horses are a precocious species that must accomplish several milestones that are critical to survival in the immediate post-birth period for their survival. One essential milestone is the successful transition from the intrauterine unconsc…
Veterinary Integration into Multi-agency Disaster Response: Training the Next Generation of Responders Open
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Drug Residues after Intravenous Anesthesia and Intrathecal Lidocaine Hydrochloride Euthanasia in Horses Open
Background Intrathecal lidocaine hydrochloride under general anesthesia has been used as an alternative method of euthanasia in equids. Carnivore, scavenger, and even human consumption of horse meat from carcasses have been anecdotally rep…