John E. McGeary
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View article: Polygenic Scores for Depression are Associated with Indices of Neighborhood Adversity
Polygenic Scores for Depression are Associated with Indices of Neighborhood Adversity Open
Genome-wide association studies have allowed for the creation of polygenic scores (PGSs) reflecting genetic liability for depression, yet recent work suggests that these PGSs may also reflect greater genetic propensity towards higher level…
View article: Associations between objectively and subjectively measured sleep outcomes among elementary school children in Rhode Island
Associations between objectively and subjectively measured sleep outcomes among elementary school children in Rhode Island Open
Objective Although sleep is essential for healthy child development, parents generally misconstrue definitions of sleep duration and sleep quality. This study examines differences between objective and parent-reported measures of sleep in …
View article: Social Connectedness and Successful Nursing Home Discharge After Heart Failure Hospitalization
Social Connectedness and Successful Nursing Home Discharge After Heart Failure Hospitalization Open
Veterans with HF who were more socially connected in the SNF setting had higher rates of successful discharge than those with lower social connectedness. Low social connectedness may be an indicator of care needs that make discharge from S…
View article: Polygenic scores for depression are associated with indices of neighborhood adversity.
Polygenic scores for depression are associated with indices of neighborhood adversity. Open
Genome-wide association studies have allowed for the creation of polygenic scores (PGSs) reflecting genetic liability for depression, yet recent work suggests that these PGSs may also reflect greater genetic propensity toward higher levels…
View article: Polygenic Scores for Depression are Associated with Indices of Neighborhood Adversity
Polygenic Scores for Depression are Associated with Indices of Neighborhood Adversity Open
Genome-wide association studies have allowed for the creation of polygenic scores (PGSs) reflecting genetic liability for depression, yet recent work suggests that these PGSs may also reflect greater genetic propensity towards higher level…
View article: Time to Death by Suicide in an Epidemiological Sample of Veterans With an Inpatient Hospitalization for Heart Failure
Time to Death by Suicide in an Epidemiological Sample of Veterans With an Inpatient Hospitalization for Heart Failure Open
Demographic, clinical, and healthcare utilization characteristics distinguished Veterans with heart failure who died by suicide from those who died by other causes. Time to death following hospital discharge did not differ between groups w…
View article: Insomnia treatment effects on negative emotionality among veterans in treatment for alcohol use disorder
Insomnia treatment effects on negative emotionality among veterans in treatment for alcohol use disorder Open
Background Insomnia symptoms are pervasive and persistent in alcohol use disorder (AUD), though little is known about the mechanisms that underlie this association. We previously found that cognitive behavioral therapy for insomnia (CBT‐I)…
View article: Bulk and Single-cell Transcriptomic Brain Data Identify Overlapping Processes and Cell-types with Human AUD and Mammalian Models of Alcohol Use
Bulk and Single-cell Transcriptomic Brain Data Identify Overlapping Processes and Cell-types with Human AUD and Mammalian Models of Alcohol Use Open
This study explores the neurobiological underpinnings of alcohol use disorder (AUD) by integrating bulk and single-cell transcriptomic data from humans, primates, and mice across three brain regions associated with addiction (i.e., prefron…
View article: Maternal smoking during pregnancy is associated with DNA methylation in early adolescence: A sibling comparison design.
Maternal smoking during pregnancy is associated with DNA methylation in early adolescence: A sibling comparison design. Open
Maternal smoking during pregnancy (MSDP) may impact offspring biological (e.g., deoxyribonucleic acid methylation [DNAm]) and behavioral (e.g., attention-deficit/hyperactivity disorder hyperactive/impulsive [ADHD-HI] symptoms) development.…
View article: 0822 The 3-30-300 Rule for Green Space Exposure and Sleep in Elementary School Children
0822 The 3-30-300 Rule for Green Space Exposure and Sleep in Elementary School Children Open
Introduction In 2015, the United Nations identified a target of “universal access to safe, inclusive and accessible, green and public spaces “to be implemented by 2030. However, few guidelines exist to equitably increase access to the heal…
View article: 0048 Investigating the Effects of Consecutive Nights of Pre-sleep Alcohol Use on Sleep Spindle Density and Distribution
0048 Investigating the Effects of Consecutive Nights of Pre-sleep Alcohol Use on Sleep Spindle Density and Distribution Open
Introduction We previously reported the impact of consecutive nights of alcohol on sleep macrostructure variables. Sleep spindle density and distribution, however, remain unexamined in response to alcohol. This report tests the hypothesis …
View article: Greenspace, stress, and health: how is epigenetics involved?
Greenspace, stress, and health: how is epigenetics involved? Open
Most expositions of the association between green space and overall health and well-being focus on psychosocial mechanisms. However, discussions of the biological underpinnings of the exposure to green space and health implications are lim…
View article: 0262 Comparing Wrist Actigraphy to a Novel Wearable (Actigpatch): Nonparametric Activity Estimation
0262 Comparing Wrist Actigraphy to a Novel Wearable (Actigpatch): Nonparametric Activity Estimation Open
Introduction Wrist actigraphy is a standard for monitoring sleep in the field; however, data quality is reduced if participants remove the device. The Actigpatch is a novel, adhesive water-resistant wearable that we have previously demonst…
View article: 0127 Effects of pre-sleep alcohol consumption on sleep and heart rate (HR)
0127 Effects of pre-sleep alcohol consumption on sleep and heart rate (HR) Open
Introduction Sympathetic nervous system (SNS) activity is relatively low, parasympathetic NS (PNS) relatively high, and heart rate (HR) is slow in NREM sleep. In tonic REM sleep, PNS activity remains high, but phasic REM sleep is associate…
View article: 0166 Effects of Evening Pre-Sleep Alcohol on Next-Day Psychomotor Vigilance (PVT) Performance
0166 Effects of Evening Pre-Sleep Alcohol on Next-Day Psychomotor Vigilance (PVT) Performance Open
Introduction Few reports have examined how pre-sleep alcohol affects performance on the next day given adequate sleep opportunity on a preferred schedule. Our goal is to identify whether alcohol intake targeting .08g% 1 hr before sleep of …
View article: A <i> MUC <scp>5</scp> B </i> Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality
A <i> MUC <span>5</span> B </i> Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality Open
Rationale: A common MUC5B gene polymorphism, rs35705950-T, is associated with idiopathic pulmonary fibrosis (IPF), but its role in severe acute respiratory syndrome coronavirus 2 infection and disease severity is unclear. Objectives: To as…
View article: Opioid Use Disorder and Alternative mRNA Splicing in Reward Circuitry
Opioid Use Disorder and Alternative mRNA Splicing in Reward Circuitry Open
Opiate/opioid use disorder (OUD) is a chronic relapsing brain disorder that has increased in prevalence in the last two decades in the United States. Understanding the molecular correlates of OUD may provide key insights into the pathophys…
View article: 0221 Pre-Sleep Breath alcohol concentrations (psBrAC) and sleep polysomnography (PSG)
0221 Pre-Sleep Breath alcohol concentrations (psBrAC) and sleep polysomnography (PSG) Open
Introduction Alcohol use before bedtime has been shown to alter sleep including decreasing sleep latency, decreasing sleep efficiency, and fragmenting sleep stage distribution. Few studies manipulate pre-sleep alcohol concentration, instea…
View article: Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene–environment correlations.
Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene–environment correlations. Open
Familial risk for depression is associated with youth exposure to self-generated dependent stressful life events and independent events that are out of youth's control. Familial risk includes both genetic and environmental influences, rais…
View article: Variability in response to theta burst TMS for PTSD: The role of epigenetic mediation
Variability in response to theta burst TMS for PTSD: The role of epigenetic mediation Open
Neurostimulation is an increasingly implemented treatment for a range of psychiatric disorders [[1]Guo Q. Li C. Wang J. Updated review on the clinical use of repetitive transcranial magnetic stimulation in psychiatric disorders.Neurosci Bu…
View article: Polygenic predisposition to venous thromboembolism is associated with increased COVID-19 positive testing rates
Polygenic predisposition to venous thromboembolism is associated with increased COVID-19 positive testing rates Open
Genetic predisposition to venous thrombosis may impact COVID-19 infection and its sequelae. Participants in the ongoing prospective cohort study, Million Veteran Program (MVP), who were tested for COVID-19, with European ancestry, were eva…
View article: <i>A MUC5B</i>gene polymorphism, rs35705950-T, confers protective effects in COVID-19 infection
<i>A MUC5B</i>gene polymorphism, rs35705950-T, confers protective effects in COVID-19 infection Open
Rationale A common MUC5B gene polymorphism, rs35705950-T, is associated with idiopathic pulmonary fibrosis, but its role in the SARS-CoV-2 infection and disease severity is unclear. Objectives To assess whether rs35705950-T confers differe…
View article: Multi-Polygenic Analysis of Nicotine Dependence in Individuals of European Ancestry
Multi-Polygenic Analysis of Nicotine Dependence in Individuals of European Ancestry Open
Introduction Heritability estimates of nicotine dependence (ND) range from 40% to 70%, but discovery GWAS of ND are underpowered and have limited predictive utility. In this work, we leverage genetically correlated traits and diseases to i…
View article: The Moderating Effects of Genetic Variations on Changes in Physical Activity Level and Cardiorespiratory Fitness in Response to a Life-Style Intervention: A Randomized Controlled Trial
The Moderating Effects of Genetic Variations on Changes in Physical Activity Level and Cardiorespiratory Fitness in Response to a Life-Style Intervention: A Randomized Controlled Trial Open
Objective Prior studies identified single nucleotide polymorphisms (SNPs) associated with physical activity (PA) level in a natural environment and intervention study: rs978656- DNAPTP6, rs10887741- PAPSS2 , rs7279064- C18orf2 , and rs6265…