John E. Mindur
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Fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis and intestinal inflammation in multiple sclerosis Open
Multiple Sclerosis (MS) has been reported to be associated with intestinal inflammation and gut dysbiosis. To elucidate the underlying biology of MS-linked gut inflammation, we investigated gut infiltration of immune cells during the devel…
Sleep exerts lasting effects on hematopoietic stem cell function and diversity Open
A sleepless night may feel awful in its aftermath, but sleep’s revitalizing powers are substantial, perpetuating the idea that convalescent sleep is a consequence-free physiological reset. Although recent studies have shown that catch-up s…
Quantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19 Open
The CovILD study is a prospective, multicenter, observational cohort study to systematically follow up patients after coronavirus disease-2019 (COVID-19). We extensively evaluated 145 COVID-19 patients at 3 follow-up visits scheduled for 6…
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy Open
Resident macrophages and recruited neutrophils cause toxicities in tumor-free tissues after immunotherapy.
Surface Layer Protein A Expressed in Clostridioides difficile DJNS06-36 Possesses an Encephalitogenic Mimotope of Myelin Basic Protein Open
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Recent studies suggest that migration of Th1 and Th17 cells specific for enteric bacteria from the gut to the CNS may lead to the initiat…
Liver X receptors are required for thymic resilience and T cell output Open
The thymus is a primary lymphoid organ necessary for optimal T cell development. Here, we show that liver X receptors (LXRs)—a class of nuclear receptors and transcription factors with diverse functions in metabolism and immunity—criticall…
Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease Open
Growth factors, such as CSFs (colony-stimulating factors), EGFs (epidermal growth factors), and FGFs (fibroblast growth factors), are signaling proteins that control a wide range of cellular functions. Although growth factor networks are c…
Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis Open
Acquisition of self-reactive effector CD4+ T cells is a major component of the autoimmune response that can occur during myocarditis, an inflammatory form of cardiomyopathy. Although the processes by which self-reactive T cells gain effect…
Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood Open
Significance Multiple sclerosis (MS) is classified as an autoimmune disease of the central nervous system (CNS). Alterations of gut microbiota (gut dysbiosis) are frequently observed in MS patients. It is still unknown how gut dysbiosis co…
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis Open
Two distinct forms of the erythropoietin receptor (EPOR) mediate the cellular responses to erythropoietin (EPO) in different tissues. EPOR homodimers signal to promote the maturation of erythroid progenitor cells. In other cell types, incl…
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes Open
Myocardial infarction (MI) elicits massive inflammatory leukocyte recruitment to the heart. Here, we hypothesized that excessive leukocyte invasion leads to heart failure and death during acute myocardial ischemia. We found that shortly an…