John E. Nichols
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View article: U.S. POINTER Study: Adherence to a Multidomain Health Behavior Change Intervention
U.S. POINTER Study: Adherence to a Multidomain Health Behavior Change Intervention Open
Background U.S. POINTER was a multisite randomized controlled trial testing the impact of multidomain lifestyle intervention on cognitive function in cognitively unimpaired older adults at risk for cognitive decline and dementia. Here we p…
View article: Machine learning center-specific models show improved IVF live birth predictions over US national registry-based model
Machine learning center-specific models show improved IVF live birth predictions over US national registry-based model Open
Expanding in vitro fertilization (IVF) access requires improved patient counseling and affordability via cost-success transparency. Clinicians ask how two types of live birth prediction (LBP) models perform: machine learning, center-specif…
View article: Predicting IVF live birth probabilities using machine learning, center-specific models: validation results and potential benefits over national registry-based models.
Predicting IVF live birth probabilities using machine learning, center-specific models: validation results and potential benefits over national registry-based models. Open
Ongoing improvement of pretreatment live birth prognostication for in vitro fertilization (IVF) is critical for informing fertility patients' treatment decisions, advocating for IVF coverage and supporting value-based IVF care. The US nati…
View article: Predicting IVF live birth probabilities using machine learning, center-specific models: validation results and potential benefits over national registry-based models
Predicting IVF live birth probabilities using machine learning, center-specific models: validation results and potential benefits over national registry-based models Open
Ongoing improvement of pretreatment live birth prognostication for in vitro fertilization (IVF) is critical for informing fertility patients’ treatment decisions, advocating for IVF coverage and supporting value-based IVF care. The US nati…
View article: Improving IVF Utilization with Patient-Centric Artificial Intelligence-Machine Learning (AI/ML): A Retrospective Multicenter Experience
Improving IVF Utilization with Patient-Centric Artificial Intelligence-Machine Learning (AI/ML): A Retrospective Multicenter Experience Open
Objectives: In vitro fertilization (IVF) has the potential to give babies to millions more people globally, yet it continues to be underutilized. We established a globally applicable and locally adaptable IVF prognostics report and framewo…
View article: O-087 Patient-centric, machine learning (ML)-based personalised prognostics supports fertility specialists to improve access to assisted reproductive technology (ART) and increase overall live birth (LB) outcomes
O-087 Patient-centric, machine learning (ML)-based personalised prognostics supports fertility specialists to improve access to assisted reproductive technology (ART) and increase overall live birth (LB) outcomes Open
Study question Does the use of patient-centric, ML-prognostics counselling report (Univfy® PreIVF Report) affect assisted reproductive technology (ART) conversion (first ART cycle usage) and LB rate (LBR)? Summary answer The use of patient…
View article: Safety monitoring in the U.S. study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (US POINTER)
Safety monitoring in the U.S. study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (US POINTER) Open
Background US POINTER is a multisite randomized clinical trial funded by the Alzheimer's Association. It is designed to evaluate whether different lifestyle interventions (exercise, nutrition, and cognitive and social stimulation) protect …
View article: Real-world experience with intravaginal culture using INVOCELL: an alternative model for infertility treatment
Real-world experience with intravaginal culture using INVOCELL: an alternative model for infertility treatment Open
This study of IVC using INVOCELL as an alternative model for infertility treatment confirms its utility as a viable alternative to standard incubator-based in vitro fertilization. The technology is compatible within the current framework o…