John F. Ervin
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View article: Markers of leucine‐rich repeat kinase 2 activity are associated with pathological protein aggregation across neurodegenerative diseases
Markers of leucine‐rich repeat kinase 2 activity are associated with pathological protein aggregation across neurodegenerative diseases Open
Background Alzheimer's disease (AD) and primary tauopathies are characterized by pathological tau aggregation, in the form of neurofibrillary tangles and dystrophic neurites. Recent evidence suggests tau pathology is also commonly observed…
View article: Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies
Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies Open
Parkinson’s disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 ( LRRK2 ) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present with phosphorylated tau and α-synucle…
View article: Detection of mild cognitive impairment of Alzheimer’s disease and tauopathy differentiation by phospho‐tau396
Detection of mild cognitive impairment of Alzheimer’s disease and tauopathy differentiation by phospho‐tau396 Open
Background In recent years, CSF and blood‐based biomarkers have been developed for premortem diagnosis of AD. However, no well‐established biomarkers are currently available for early detection of AD in patients with mild cognitive impairm…
View article: GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in <i>C. elegans</i>
GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in <i>C. elegans</i> Open
Aging causes functional decline and degeneration of neurons and is a major risk factor of neurodegenerative diseases. To investigate the molecular mechanisms underlying neuronal aging, we developed a new pipeline for neuronal proteomic pro…
View article: Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation
Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation Open
Tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Such misfolded t…
View article: Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry
Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry Open
In this genome-wide association study, variants at the APBB2 locus demonstrated differential association with primary open-angle glaucoma by ancestry. If validated in additional populations this finding may have implications for risk asses…
View article: The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target
The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target Open
Our hypothesis is that changes in gene and protein expression are crucial to the development of late-onset Alzheimer’s disease. Previously we examined how DNA alleles control downstream expression of RNA transcripts and how those relations…
View article: Cover Image
Cover Image Open
The cover image, by Naoko Obi et al., is based on the Research Article Development of Drug Discovery Screening System by Molecular Interaction Kinetics Mass Spectrometry, DOI: 10.1002/rcm.8083.
View article: O2‐06‐01: The Human Brainome: Human Brain Genome, Transcriptome, and Proteome Integration
O2‐06‐01: The Human Brainome: Human Brain Genome, Transcriptome, and Proteome Integration Open
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