Explanipedia

ALCAPA Diagnosed in an Elderly Patient Open

Thomas Pointer, John F. Keaney, Samuel W. Reinhardt, Tony Pastor · 2025

69 Pulsed field ablation for the treatment of atrial fibrillation in an Irish hypertrophic cardiomyopathy cohort: a retrospective observational study Open

C. Michael Cawley, K Laurilla, L Rosalejos, M Marcojos, Jin Li , et al. · 2025

Use of AI to classify MS Disability during the time of Covid Open

Charisse Litchman, Noah Rubin, Larry Rubin, Tess Litchman, Sarah Wesely , et al. · 2023

Background: Lack of access to MS specialty care, exacerbated by the COVID-19 pandemic, has prevented many patients suffering from Multiple Sclerosis (MS) and other neurodegenerative diseases from receiving timely in-person care, resulting …

Inflammatory stress-mediated chromatin changes underlie dysfunction in endothelial cells Open

Haibo Liu, Amada D. Caliz, Heather Learnard, Milka Koupenova, John F. Keaney , et al. · 2023

Inflammatory stresses underlie endothelial dysfunction and contribute to the development of chronic cardiovascular disorders such as atherosclerosis and vascular fibrosis. The initial transcriptional response of endothelial cells to pro-in…

47 Pulse field ablation in Irish atrial fibrillation. Patient characteristics, safety, and single operator experience from the first 50 cases Open

Dermot O’Hare, Louisa O’Neill, John F. Keaney, Patrick Murray, David Keane · 2023

Introduction Pulse Field Ablation (PFA) is an exciting novel technology in the field of Atrial Fibrillation (AF). The technology delivers high amplitude electrical pulses with tissue specificity to target myocardium. This technology offers…

Rapid, accurate publication and dissemination of clinical trial results: benefits and challenges Open

Faı̈ez Zannad, Filippo Crea, John F. Keaney, Stuart Spencer, Joseph A. Hill , et al. · 2023

Large-scale clinical trials are essential in cardiology and require rapid, accurate publication, and dissemination. Whereas conference presentations, press releases, and social media disseminate information quickly and often receive consid…

Picking the Locked Door Open

Noel Fitzpatrick, John F. Keaney, Edward T. Keelan, Kevin Walsh, Gábor Széplaki · 2023

The management of atrial septal defects (ASDs) has been revolutionized by the advent of percutaneous transvenous occlusion devices. This case series describes techniques required to perform a transeptal puncture safely and effectively in p…

Mitigation of aircraft noise-induced vascular dysfunction and oxidative stress by exercise, fasting, and pharmacological α1AMPK activation: molecular proof of a protective key role of endothelial α1AMPK against environmental noise exposure Open

Miroslava Kvandová, Sanela Rajlic, Paul Stamm, Isabella Schmal, Dominika Mihaliková , et al. · 2023

Aims Environmental stressors such as traffic noise represent a global threat, accounting for 1.6 million healthy life years lost annually in Western Europe. Therefore, the noise-associated health side effects must be effectively prevented …

The impact of steerable sheath visualization during catheter ablation for atrial fibrillation Open

Noel Fitzpatrick, A Mittal, Joseph Galvin, Gael Jauvert, John F. Keaney , et al. · 2023

Aims Incorporating a steerable sheath that can be visualized using an electroanatomical mapping (EAM) system may allow for more efficient mapping and catheter placement, while reducing radiation exposure, during ablation procedures for atr…

Mitogen-activated protein kinase kinase 7 in inflammatory, cancer, and neurological diseases Open

Amada D. Caliz, Anastassiia Vertii, Vijay Fisch, Soonsang Yoon, Hyung‐Jin Yoo , et al. · 2022

Stress-activated mitogen-activated protein kinase kinase 7 (MKK7) is a member of the dual-specificity mitogen-activated protein kinase family. In the human body, MKK7 controls essential physiological processes, including but not limited to…

9 Long term results in real world ablation index guided pulmonary vein isolation – 5 years of follow-up from the MPH AF ablation registry Open

Noel Fitzpatrick, Szilvia Herczeg, Kathryn L. Hong, A Mittal, Usama Boles , et al. · 2022

Introduction Catheter ablation (CA) for symptomatic atrial fibrillation (AF) offers the best outcomes for patients in terms of freedom from AF and carries a IA recommendation from the ESC for drug refractory symptomatic AF. Despite current…

Association of Thromboxane Generation With Survival in Aspirin Users and Nonusers Open

Jeffrey J. Rade, Bruce Barton, Ramachandran S. Vasan, Shari S. Kronsberg, Vanessa Xanthakis , et al. · 2022

Lack of Endothelial α1AMPK Reverses the Vascular Protective Effects of Exercise by Causing eNOS Uncoupling Open

Thomas Jansen, Miroslava Kvandová, Isabella Schmal, Sanela Kalinovic, Paul Stamm , et al. · 2021

Voluntary exercise training is an effective way to prevent cardiovascular disease, since it results in increased NO bioavailability and decreased reactive oxygen species (ROS) production. AMP-activated protein kinase (AMPK), especially its…

Healthcare-acquired clusters of COVID-19 across multiple wards in a Scottish health board Open

Stephanie J. Dancer, Kylie Cormack, Miranda Loh, C. Coulombe, Linda Thomas , et al. · 2021

10 Automated high density left atrial voltage mapping of low voltage areas in atrial fibrillation differs from sinus rhythm Open

James Mannion, SJ Lennon, John F. Keaney, Joseph Galvin, J. O’Brien , et al. · 2021

Introduction Low voltage areas (LVAs) are used as surrogate markers for diseased left atrial (LA) tissue and scar distribution. LVAs can be overestimated when measured in atrial fibrillation (AF) due to factors such as variable contact bet…

2 Arrhythmogenic substrate stratification of posterior left atrial wall in atrial fibrillation versus sinus rhythm in persistent atrial fibrillation using automated voltage analysis Open

James Mannion, SJ Lennon, John F. Keaney, Joseph Galvin, J. O’Brien , et al. · 2021

Introduction Pulmonary vein isolation (PVI) remains the main procedural target in atrial fibrillation (AF) ablation. The posterior left atrial (LA) wall contains multiple potential mechanisms that can initiate and sustain persistent AF (Pe…

Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice Open

Amada D. Caliz, Hyung‐Jin Yoo, Anastassiia Vertii, Ana C. Dolan, Cathy Tournier , et al. · 2021

Mitogen kinase kinase 4 (MKK4) and mitogen kinase kinase 7 (MKK7) are members of the MAP2K family that can activate downstream mitogen-activated protein kinases (MAPKs). MKK4 has been implicated in the activation of both c-Jun N-terminal k…

Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice Open

Amada D. Caliz, Hyung‐Jin Yoo, Anastassiia Vertii, Ana C. Dolan, Cathy Tournier , et al. · 2021

Mitogen kinase kinase 4 (MKK4) and mitogen kinase kinase 7 (MKK7) are members of the MAP2K family that can activate downstream mitogen-activated protein kinases (MAPKs). MKK4 has been implicated in the activation of both c-Jun N-terminal k…

Mitogen Kinase Kinase (MKK7) controls cytokine production in vitro and in vivo in mice Open

Amada D. Caliz, Hyung‐Jin Yoo, Anastassiia Vertii, Cathy Tournier, Roger J. Davis , et al. · 2021

Mitogen kinase kinase 4 (MKK4) and Mitogen kinase kinase 7 (MKK7) are members of the MAP2K family which can activate downstream mitogen-activated protein kinases (MAPKs). MKK4 has been implicated in the activation of both, c-Jun N-terminal…

PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1 Open

Shashi Kant, Khanh‐Van Tran, Miroslava Kvandová, Amada D. Caliz, Hyung‐Jin Yoo , et al. · 2021

Fluid shear stress (FSS) is known to mediate multiple phenotypic changes in the endothelium. Laminar FSS (undisturbed flow) is known to promote endothelial alignment to flow that is key to stabilizing the endothelium and rendering it resis…

Cigarette Smoking Is Related to Endothelial Dysfunction of Resistance, but Not Conduit Arteries in the General Population—Results From the Gutenberg Health Study Open

Omar Hahad, Natalie Arnold, Jürgen H. Prochaska, Marina Panova‐Noeva, Andreas Schulz , et al. · 2021

Aims: Cigarette smoking is one of the most complex and least understood cardiovascular risk factors. Importantly, differences in the tobacco-related pathophysiology of endothelial dysfunction, an early event in atherogenesis, between circu…

Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway Open

Thuan Thai, Fei Zhong, Lei Dang, Enoch Chan, Jacqueline Ku , et al. · 2021

Nox4 mediates skeletal muscle metabolic responses to exercise Open

Kalyn S. Specht, Shashi Kant, Adele K. Addington, Ryan P. McMillan, Matthew W. Hulver , et al. · 2021

We report that H₂O₂ and Nox4 promote immediate responses to exercise in skeletal muscle. Glucose and fatty acid oxidation were blunted in the Nox4-deficient mice post-exercise, potentially through regulation of UCP3 e…

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels Open

Abbas Dehghan, Josée Dupuis, Maja Barbalić, Joshua C. Bis, Guðný Eiríksdóttir , et al. · 2020

C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We aimed to identify genetic variants that are associated with CRP levels.

6 The role of ablation index on repeat pulmonary vein isolation procedures in persistent atrial fibrillation: a short term outcome Open

SJ Lennon, James Mannion, Gábor Széplaki, John F. Keaney, Edward T. Keelan , et al. · 2020

Introduction Ablation Index (AI) is a novel catheter-based parameter developed to improve and increase efficacy and safety of Pulmonary Vein Isolations (PVI) in the treatment of Atrial Fibrillation (AF). This method involves the incorporat…

10 Left atrial function by echocardiography is independent of degree of left atrial electrical scar Open

Rory Gallen, Catherine McGorrian, T Keelan, Joseph Galvin, John F. Keaney · 2020

Introduction Assessment of left atrial function via transthoracic echocardiography (TTE) is often performed by measuring the transmitral A wave in sinus rhythm. Left atrial (LA) fibrosis plays an important role in the pathogenesis and perp…

43 Micra transcatheter pacing system implantation and outcomes in a single centre Open

David Connellan, C.L. Brady, Paul Ryan, Kevin Walsh, John F. Keaney · 2020

Introduction and Objectives Traditional cardiac pacemakers incorporate transvenous leads. Recently leadless pacemakers have been approved. The Micra™ pacemaker is such a device which is inserted percutaneously via the femoral vein into the…

Plasma microRNAs are Associated with Atrial Fibrillation (the miRhythm Study) and Change After Catheter-ablation Open

David D. McManus, Kahraman Tanrıverdi, Honghuang Lin, Nada Esa, Menhel Kinno , et al. · 2020

Background: Atrial fibrillation (AF) is the most common dysrhythmia in the U.S. and Europe. Few biomarkers exist to identify individuals at risk for AF. Cardiac microRNAs (miRNAs) have been implicated in susceptibility to AF and are detect…

Circulating microRNAs are associated with Paroxysmal or Persistent Atrial Fibrillation Open

David D. McManus, Jeanine Ward, Amir Y. Shaikh, Khushleen Jaggi, Victor Ambros , et al. · 2020

Introduction: Novel methods of identifying individuals at risk for atrial fibrillation (AF) are needed. MicroRNAs (MiRNAs) regulate gene expression in a number of cardiovascular diseases, including AF. It is unknown, however, if key circul…

Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes Open

Thomas Münzel, Omar Hahad, Marin Kuntić, John F. Keaney, John Deanfield , et al. · 2020

Tobacco smoking is a leading cause of non-communicable disease globally and is a major risk factor for cardiovascular disease (CVD) and lung disease. Importantly, recent data by the World Health Organizations (WHO) indicate that in the las…

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