John Finnie
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View article: Spontaneous Myocardial Infarction in a Translational Porcine Model of Coronary Atherosclerosis: A Pilot Study
Spontaneous Myocardial Infarction in a Translational Porcine Model of Coronary Atherosclerosis: A Pilot Study Open
This pilot study characterizes the spectrum of atherosclerotic coronary artery pathologies in a porcine model of streptozotocin-induced diabetes, with a particular focus on the natural progression of atherosclerotic plaques. Four pigs (des…
View article: Genetic Ablation and Multi-Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models
Genetic Ablation and Multi-Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models Open
Background CEP55 is a centrosomal protein with emerging oncogenic roles. It is overexpressed in many cancers, where it drives genomic instability, phenocopies PTEN loss and hyperactivates the PI3K/AKT pathway, thereby promoting aggressive …
View article: A longitudinal evaluation of localised chronic <i>Pseudomonas aeruginosa</i> infection in cystic fibrosis rat models
A longitudinal evaluation of localised chronic <i>Pseudomonas aeruginosa</i> infection in cystic fibrosis rat models Open
Recurrent bacterial infections with Pseudomonas aeruginosa result in chronic airway inflammation, lung damage and eventual respiratory failure, and are the major cause of morbidity and mortality in people with cystic fibrosis (CF). Animal …
View article: An immunocompetent rat model of Mycobacterium abscessus multinodular granulomatous lung infection
An immunocompetent rat model of Mycobacterium abscessus multinodular granulomatous lung infection Open
Animal models that can mimic progressive granulomatous pulmonary disease (PD) due to non-tuberculous mycobacteria (NTM) have not been established in rats to date. These models could assist with the study of the pathophysiology of NTM-PD as…
View article: Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy
Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy Open
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with extremely limited therapeutic options. One key pathological feature of ALS is the abnormal accumulation of misfolded proteins within motor neurons. Hence, …
View article: Striking and widespread microglial activation in the brains of Southdown lambs with type II glucocerebrosidosis (neuronopathic Gaucher disease)
Striking and widespread microglial activation in the brains of Southdown lambs with type II glucocerebrosidosis (neuronopathic Gaucher disease) Open
Glucocerebrosidosis (termed Gaucher disease in humans) is a lysosomal storage disease, caused by a deficiency of the enzyme glucocerebrosidase, which results in accumulation of the glycolipid substrate glucocerebroside in the macrophage-mo…
View article: Preclinical and clinical evaluation through serial colonoscopic evaluation of neratinib‐induced diarrhea in <scp>HER2</scp>‐positive breast cancer—A pilot study
Preclinical and clinical evaluation through serial colonoscopic evaluation of neratinib‐induced diarrhea in <span>HER2</span>‐positive breast cancer—A pilot study Open
The irreversible pan‐HER tyrosine kinase inhibitor neratinib is approved for patients with HER2‐positive, early‐stage and metastatic breast cancer (BC). Neratinib‐associated diarrhea is the most common reason for early discontinuation. Pre…
View article: Ferroptosis – a potential feature underlying neratinib-induced colonic epithelial injury
Ferroptosis – a potential feature underlying neratinib-induced colonic epithelial injury Open
View article: Study of the Structure of Hyperbranched Polyglycerol Coatings and Their Antibiofouling and Antithrombotic Applications
Study of the Structure of Hyperbranched Polyglycerol Coatings and Their Antibiofouling and Antithrombotic Applications Open
While blood‐contacting materials are widely deployed in medicine in vascular stents, catheters, and cannulas, devices fail in situ because of thrombosis and restenosis. Furthermore, microbial attachment and biofilm formation is not an unco…
View article: Staphylococcus aureus Biofilm-Secreted Factors Cause Mucosal Damage, Mast Cell Infiltration, and Goblet Cell Hyperplasia in a Rat Rhinosinusitis Model
Staphylococcus aureus Biofilm-Secreted Factors Cause Mucosal Damage, Mast Cell Infiltration, and Goblet Cell Hyperplasia in a Rat Rhinosinusitis Model Open
Chronic rhinosinusitis (CRS) is an inflammatory condition of the sinonasal mucosa. Despite being a common health issue, the exact cause of CRS is yet to be understood. However, research suggests that Staphylococcus aureus, particularly in …
View article: A Novel Model of Staphylococcus aureus-Induced Lymphoplasmacytic Rhinosinusitis in Rats
A Novel Model of Staphylococcus aureus-Induced Lymphoplasmacytic Rhinosinusitis in Rats Open
Chronic rhinosinusitis (CRS) is characterized by sinonasal mucosal inflammation. Staphylococcus aureus (S. aureus) is associated with severe CRS phenotypes. Different animal models have been proposed to study the association of CRS and S. …
View article: Clostridium perfringens Type D Epsilon Toxin Causes Blood–Retinal Barrier Microvascular Damage and Diffuse Retinal Vasogenic Oedema
Clostridium perfringens Type D Epsilon Toxin Causes Blood–Retinal Barrier Microvascular Damage and Diffuse Retinal Vasogenic Oedema Open
Clostridium perfringens type D epsilon toxin (ETX) causes severe retinal microvascular endothelial injury in the rat. The resulting blood–retinal barrier (BRB) breakdown leads to increased vascular permeability, which was detected immunohi…
View article: Haemostatic efficacy and inflammatory response of a novel beta-chitin patch in a cerebral small vessel injury model – A pilot study
Haemostatic efficacy and inflammatory response of a novel beta-chitin patch in a cerebral small vessel injury model – A pilot study Open
All haemostats controlled bleeding, with beta-chitin demonstrating a non-inferior TTH compared to Floseal. However, it resulted in intense granulomatous and fibrotic changes, including degenerative neuronal reactions. More extensive studie…
View article: <i>Staphylococcus aureus</i>biofilm secreted factors cause mucosal damage, mast cell infiltration and goblet cell hyperplasia in a rat rhinosinusitis model
<i>Staphylococcus aureus</i>biofilm secreted factors cause mucosal damage, mast cell infiltration and goblet cell hyperplasia in a rat rhinosinusitis model Open
Chronic Rhinosinusitis (CRS) is an inflammatory condition of the paranasal sinus mucosa. Despite being a common health issue, the exact cause of CRS is yet to be understood. However, research suggests that Staphylococcus aureus , particula…
View article: Neurologic disease produced by <i>Rathayibacter toxicus</i>-derived corynetoxins
Neurologic disease produced by <i>Rathayibacter toxicus</i>-derived corynetoxins Open
Corynetoxins, members of the tunicamycin group of antibiotics, are produced by the bacterium, Rathayibacter toxicus. They cause a severe neurologic disorder in domestic livestock, are hepatotoxins, and can damage retinal photoreceptors. Fo…
View article: Avian riboflavin deficiency causes reliably reproducible peripheral nerve demyelination and, with vitamin supplementation, rapid remyelination
Avian riboflavin deficiency causes reliably reproducible peripheral nerve demyelination and, with vitamin supplementation, rapid remyelination Open
Riboflavin deficiency produces severe peripheral neve demyelination in young, rapidly growing chickens. While this naturally-occurring vitamin B2 deficiency can cause a debilitating peripheral neuropathy, and mortality, in poultry flocks, …
View article: Does supplementation of oocytes with additional mtDNA influence developmental outcome?
Does supplementation of oocytes with additional mtDNA influence developmental outcome? Open
View article: Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice Open
View article: Pathology and Pathogenesis of Brain Lesions Produced by Clostridium perfringens Type D Epsilon Toxin
Pathology and Pathogenesis of Brain Lesions Produced by Clostridium perfringens Type D Epsilon Toxin Open
Clostridium perfringens type D epsilon toxin (ETX) produces severe, and frequently fatal, neurologic disease in ruminant livestock. The disorder is of worldwide distribution and, although vaccination has reduced its prevalence, ETX still c…
View article: Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice Open
αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft models hav…
View article: Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice Open
αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft models hav…
View article: Animal models of pediatric abusive head trauma
Animal models of pediatric abusive head trauma Open
View article: Hyperbranched polyglycerol coated vascular stents – a non-pharmacological approach to reducing device-triggered thrombosis and restenosis
Hyperbranched polyglycerol coated vascular stents – a non-pharmacological approach to reducing device-triggered thrombosis and restenosis Open
Synthetic materials with an innate ability to avoid the foreign-body-response remain an unrealized goal that would transform the medical device industry. The balance of bulk material properties, that enable a device to perform as intended,…
View article: Efficacy and Safety of Novel Beta-Chitin Patches as Haemostat in Rat Vascular and Neurosurgical Model
Efficacy and Safety of Novel Beta-Chitin Patches as Haemostat in Rat Vascular and Neurosurgical Model Open
Background Intraoperative hemorrhage is a major cause of poor post-operative outcome. Beta-chitin patch has previously been found to be an effective haemostat, but whether modifying the patch can improve its efficacy and safety, remains un…
View article: Red neurons in ovine polioencephalomalacia (cerebrocortical necrosis) are strongly amyloid precursor protein immunopositive
Red neurons in ovine polioencephalomalacia (cerebrocortical necrosis) are strongly amyloid precursor protein immunopositive Open
View article: The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota
The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota Open
View article: Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis
Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis Open
Homozygous nonsense mutations in CEP55 are associated with several congenital malformations that lead to perinatal lethality suggesting that it plays a critical role in regulation of embryonic development. CEP55 has previously been studied…
View article: The susceptibility of the aortic root: porcine aortic rupture testing under cardiopulmonary bypass
The susceptibility of the aortic root: porcine aortic rupture testing under cardiopulmonary bypass Open
Background In our earlier study on the functional limits of the aneurysmal aortic root we determined the pig root is susceptible to failure at high aortic pressures levels. We established a pig rupture model using cardiopulmonary bypass to…
View article: Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis
Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis Open
Homozygous nonsense mutations in CEP55 are associated with several congenital malformations that lead to perinatal lethality suggesting that it plays a critical role in regulation of embryonic development. CEP55 has previously been studied…
View article: Histological regional analysis of the aortic root and thoracic ascending aorta: a complete analysis of aneurysms from root to arch
Histological regional analysis of the aortic root and thoracic ascending aorta: a complete analysis of aneurysms from root to arch Open
Background Although aortic root and ascending aortic aneurysms are treated the same, they differ in embryological development and pathological processes. This study examines the microscopic structural differences between aortic root and as…