John V. Forrester
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View article: Myeloid cell protein tyrosine phosphatase 1B (PTP1B) drives retinal neurodegeneration in diabetic mice
Myeloid cell protein tyrosine phosphatase 1B (PTP1B) drives retinal neurodegeneration in diabetic mice Open
Diabetic retinopathy (DR) is the leading cause of vision loss in the working age population with public health economic implications worldwide. Systemic inflammation and leukocyte activation are early events in diabetes, while microglial a…
View article: Lung immune challenge study protocol: controlled exposure to inhaled resiquimod (R848) to study mechanisms of inflammation
Lung immune challenge study protocol: controlled exposure to inhaled resiquimod (R848) to study mechanisms of inflammation Open
This study aims to develop a human lung immune challenge model using inhaled Resiquimod (R848), a Toll-like receptor 7/8 agonist, to investigate inflammatory mechanisms involved in the human respiratory mucosa in health and disease. This a…
View article: BS14 Myeloid cell protein tyrosine phosphatase 1B as a target to prevent western diet-induced retinopathy
BS14 Myeloid cell protein tyrosine phosphatase 1B as a target to prevent western diet-induced retinopathy Open
Background The prevalence of obesity has tripled over the last 50 years, with overweight and obese individuals occupying a third of the global population. Western diet is considered a major contributor to the growing rate of obesity, despi…
View article: Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis
Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis Open
Restoration of immunological tolerance to self antigens has been a major drive in understanding the mechanisms of, and developing new treatments for, autoimmune and autoinflammatory disease. Sessile dendritic cells (DC) are considered the …
View article: The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis
The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis Open
Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population. Inflammation in HSK is chemokine-dependent, particularly CXCL10 and less so …
View article: Lymphopenia and local antigen presentation combine to induce colitis in a transgenic mouse model of uveitis
Lymphopenia and local antigen presentation combine to induce colitis in a transgenic mouse model of uveitis Open
Undifferentiated uveitis (intraocular inflammation, IOI) is an idiopathic sight-threatening, presumed autoimmune disease, accountable for ~ 10% of all blindness in the developed world. We have investigated the association of uveitis with i…
View article: Immune Privilege Furnishes a Niche for Latent Infection
Immune Privilege Furnishes a Niche for Latent Infection Open
The microenvironment of the CNS (eye and brain) is fertile ground for infection if the barriers are breached. The result of pathogen invasion is often devastating destruction of tissues. In the eye, inflammation is broadly classified eithe…
View article: A Role for Folate in Microbiome-Linked Control of Autoimmunity
A Role for Folate in Microbiome-Linked Control of Autoimmunity Open
The microbiome exerts considerable control over immune homeostasis and influences susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), …
View article: Immune Privilege: The Microbiome and Uveitis
Immune Privilege: The Microbiome and Uveitis Open
Immune privilege (IP), a term introduced to explain the unpredicted acceptance of allogeneic grafts by the eye and the brain, is considered a unique property of these tissues. However, immune responses are modified by the tissue in which t…
View article: Severity of Experimental Autoimmune Uveitis Is Reduced by Pretreatment with Live Probiotic Escherichia coli Nissle 1917
Severity of Experimental Autoimmune Uveitis Is Reduced by Pretreatment with Live Probiotic Escherichia coli Nissle 1917 Open
Non-infectious uveitis is considered an autoimmune disease responsible for a significant burden of blindness in developed countries and recent studies have linked its pathogenesis to dysregulation of the gut microbiota. We tested the immun…
View article: The Role of Inflammation in Diabetic Retinopathy
The Role of Inflammation in Diabetic Retinopathy Open
Inflammation is central to pathogenic processes in diabetes mellitus and the metabolic syndrome and particularly implicates innate immunity in the development of complications. Inflammation is a primary event in Type 1 diabetes where infec…
View article: Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects
Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects Open
Cell therapies for autoimmune diseases using tolerogenic dendritic cells (tolDC) have been promisingly explored. A major stumbling block has been generating stable tolDC, with low risk of converting to mature immunogenic DC (mDC), exacerba…
View article: Treatment With FoxP3+ Antigen-Experienced T Regulatory Cells Arrests Progressive Retinal Damage in a Spontaneous Model of Uveitis
Treatment With FoxP3+ Antigen-Experienced T Regulatory Cells Arrests Progressive Retinal Damage in a Spontaneous Model of Uveitis Open
We specify the clinical features of a spontaneous experimental autoimmune uveitis (EAU) model, in which foreign hen-egg lysozyme (HEL) is expressed in the retina, controlled by the promoter for interphotoreceptor retinol binding protein (I…
View article: TGF‐β1‐activated type 2 dendritic cells promote wound healing and induce fibroblasts to express tenascin c following corneal full‐thickness hydrogel transplantation
TGF‐β1‐activated type 2 dendritic cells promote wound healing and induce fibroblasts to express tenascin c following corneal full‐thickness hydrogel transplantation Open
We showed previously that 1-ethyl-3-(3-dimethylamino-propyl)-carbodiimide hydrochloride (EDC) cross-linked recombinant human collagen III hydrogels promoted stable regeneration of the human cornea (continued nerve and stromal cell repopula…
View article: Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology
Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology Open
The transepithelial potential difference ( TEP ) across the retinal pigment epithelial ( RPE ) is dependent on ionic pumps and tight junction “seals” between epithelial cells. RPE cells release neurotrophic growth factors such as pigment e…
View article: Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye
Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye Open
Recent outbreaks of Ebola and Zika have highlighted the possibility that viruses may cause enduring infections in tissues like the eye, including the neural retina, which have been considered immune privileged. Whether this is a peculiarit…
View article: Endogenous bioelectric currents promote differentiation of the mammalian lens
Endogenous bioelectric currents promote differentiation of the mammalian lens Open
The functional roles of bioelectrical signals (ES) created by the flow of specific ions at the mammalian lens equator are poorly understood. We detected that mature, denucleated lens fibers expressed high levels of the α1 and β1 subunits o…
View article: Conceptualizing community resilience to natural hazards – theemBRACE framework
Conceptualizing community resilience to natural hazards – theemBRACE framework Open
The level of community is considered to be vital for building disaster resilience. Yet, community resilience as a scientific concept often remains vaguely defined and lacks the guiding characteristics necessary for analysing and enhancing …
View article: Acute progressive paravascular placoid neuroretinopathy with negative-type electroretinography in paraneoplastic retinopathy
Acute progressive paravascular placoid neuroretinopathy with negative-type electroretinography in paraneoplastic retinopathy Open
A spectrum of autoreactive anti-retinal antibodies is associated with a unique phenotype of acute progressive paravascular placoid neuroretinopathy resulting in degeneration of photoreceptor cells, inner retinal dysfunction and classic ele…
View article: Lipopolysaccharide‐primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms
Lipopolysaccharide‐primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms Open
Summary Exposure of bone‐marrow‐derived dendritic cells ( BMDC ) to high‐dose ultrapure lipopolysaccharide for 24 hr ( LPS ‐primed BMDC ) enhances their potency in preventing inter‐photoreceptor retinoid binding protein: complete Freund's …