John Frean
YOU?
Author Swipe
View article: Case report: Brucella canis infection in a resident of the Eastern Cape Province, South Africa
Case report: Brucella canis infection in a resident of the Eastern Cape Province, South Africa Open
Brucella canis was isolated from the blood of a febrile adolescent male living in the Eastern Cape Province of South Africa. The apparent risk factor for acquiring the infection was ownership of dogs used for hunting small animals. The pat…
View article: Central Nervous System Infection by Free-Living Nematode Cephalobus cubaensis in a Human Host in Africa
Central Nervous System Infection by Free-Living Nematode Cephalobus cubaensis in a Human Host in Africa Open
Background: Human central nervous system infections due to free-living nematodes, although extremely rare, are usually fatal. Immunodeficiency has not been a feature of most of these cases, unlike the situation pertaining to disseminated S…
View article: Central Nervous System Infection by Free-Living Nematode Cephalobus cubaensis in a Human Host in Africa
Central Nervous System Infection by Free-Living Nematode Cephalobus cubaensis in a Human Host in Africa Open
Human central nervous system infections due to free-living nematodes, although extremely rare, are usually fatal. Immunodeficiency has not been a feature of most of these cases, unlike the situation pertaining to disseminated Strongyloides…
View article: A case of babesiosis in a returning traveller
A case of babesiosis in a returning traveller Open
Case highlighting overlapping characteristics of Babesia and malaria infection, necessitating close clinical and laboratory correlation to confirm diagnosis.
View article: Remembering Professor Peter A. Leggat, AM, ADC (1961–2023)
Remembering Professor Peter A. Leggat, AM, ADC (1961–2023) Open
Professor Peter Leggat, the Immediate Past President of the Australasian College of Tropical Medicine (ACTM), passed away peacefully in Brisbane on 20 September 2023 [...]
View article: Brucellosis Seropositivity Using Three Serological Tests and Associated Risk Factors in Abattoir Workers in Gauteng Province, South Africa
Brucellosis Seropositivity Using Three Serological Tests and Associated Risk Factors in Abattoir Workers in Gauteng Province, South Africa Open
Abattoir workers are liable to zoonotic infections from animals and animal products, primarily to diseases with asymptomatic and chronic clinical manifestations in animals, such as brucellosis. No published reports exist on the seroprevale…
View article: Brucellosis Seropositivity Using Three Serological Tests and Associated Risk Factors in Abattoir Workers in Gauteng Province, South Africa
Brucellosis Seropositivity Using Three Serological Tests and Associated Risk Factors in Abattoir Workers in Gauteng Province, South Africa Open
Abattoir workers are liable to zoonotic infections from animals and animal products, pri-marily to diseases with asymptomatic and chronic clinical manifestations in animals such as brucellosis. No published reports exist on the seroprevale…
View article: Forgotten but not gone in rural South Africa: Urinary schistosomiasis and implications for chronic kidney disease screening in endemic countries
Forgotten but not gone in rural South Africa: Urinary schistosomiasis and implications for chronic kidney disease screening in endemic countries Open
Background: Urinary schistosomiasis caused by infection with Schistosoma haematobium (S. haematobium) remains endemic in Africa and is associated with haematuria and albuminuria/proteinuria. Kidney Disease Improving Global Outcomes clinica…
View article: Forgotten but not gone in rural South Africa: Urinary schistosomiasis and implications for chronic kidney disease screening in endemic countries
Forgotten but not gone in rural South Africa: Urinary schistosomiasis and implications for chronic kidney disease screening in endemic countries Open
Background: Urinary schistosomiasis caused by infection with Schistosoma haematobium (S. haematobium) remains endemic in Africa and is associated with haematuria and albuminuria/proteinuria. Kidney Disease Improving Global Outcomes clinica…
View article: ZOONOSIS AS A CAUSE OF ACUTE FEBRILE ILLNESS AT A ONE HEALTH INTERFACE IN RURAL SOUTH AFRICA: IT'S THE LITTLE FIVE, NOT THE BIG FIVE
ZOONOSIS AS A CAUSE OF ACUTE FEBRILE ILLNESS AT A ONE HEALTH INTERFACE IN RURAL SOUTH AFRICA: IT'S THE LITTLE FIVE, NOT THE BIG FIVE Open
The Mnisi area of Bushbuckridge District, Mpumalanga Province, South Africa, has a population of approximately 80 000, mainly agro-pastoralists. The area is bordered by the Kruger National Park and contact between wildlife, livestock and h…
View article: Forgotten but not gone in rural South Africa: Urinary schistosomiasis and implications for chronic kidney disease screening in endemic countries
Forgotten but not gone in rural South Africa: Urinary schistosomiasis and implications for chronic kidney disease screening in endemic countries Open
Background: Urinary schistosomiasis caused by infection with Schistosoma haematobium (S. haematobium) remains endemic in Africa and is associated with haematuria and albuminuria/proteinuria. Kidney Disease Improving Global Outcomes clinica…
View article: COVID-19: Current Status and Future Prospects
COVID-19: Current Status and Future Prospects Open
This second Special Issue in a series of Special Issues in Tropical Medicine and Infectious Disease looks at recent global research on the current Coronavirus (COVID-19) Pandemic [...]
View article: Neoehrlichiosis in Symptomatic Immunocompetent Child, South Africa
Neoehrlichiosis in Symptomatic Immunocompetent Child, South Africa Open
We describe a case of neoehrlichiosis in an immunocompetent child with acute febrile illness in South Africa. Neoehrlichiosis was diagnosed by PCR on 16S rDNA from bone marrow aspirate. Phylogenetic analysis indicated an organism closely r…
View article: Dataset From: Forgotten but not gone in rural South Africa: Urinary schistosomiasis and implications for chronic kidney disease screening in endemic countries
Dataset From: Forgotten but not gone in rural South Africa: Urinary schistosomiasis and implications for chronic kidney disease screening in endemic countries Open
Supporting dataset showing sociodemographic data from this population-based cohort study.
View article: Disseminated Human Subarachnoid Coenurosis
Disseminated Human Subarachnoid Coenurosis Open
Background: Traditionally, human coenurosis has been ascribed to Taenia multiceps while neurocysticercosis has been attributed solely to Taenia solium infection. Historically, however, the identification and differentiation of cestodal inf…
View article: Where Have All the Diagnostic Morphological Parasitologists Gone?
Where Have All the Diagnostic Morphological Parasitologists Gone? Open
Advances in laboratory techniques have revolutionized parasitology diagnostics over the past several decades. Widespread implementation of rapid antigen detection tests has greatly expanded access to tests for global parasitic threats such…
View article: An Impact Factor for Tropical Medicine and Infectious Disease
An Impact Factor for Tropical Medicine and Infectious Disease Open
Tropical Medicine and Infectious Disease (TMID or TropicalMed) was established in 2016 [...]
View article: Exposure of South African Abattoir Workers to Coxiella burnetii
Exposure of South African Abattoir Workers to Coxiella burnetii Open
Abattoir workers may contract Q fever by inhalation of Coxiella burnetii bacteria in aerosols generated by slaughtering livestock, or in contaminated dust. We estimated the seroprevalence of C. burnetii and examined the associated factors …
View article: Clinical Improvement of Disseminated Acanthamoeba Infection in a Patient with Advanced HIV Using a Non-Miltefosine-Based Treatment Regimen in a Low-Resource Setting
Clinical Improvement of Disseminated Acanthamoeba Infection in a Patient with Advanced HIV Using a Non-Miltefosine-Based Treatment Regimen in a Low-Resource Setting Open
Disseminated Acanthamoeba species infection is likely an underrecognized and underdiagnosed opportunistic infection in patients with advanced human immunodeficiency virus (HIV) disease in South Africa. It presents a unique clinical challen…
View article: COVID-19: Current Challenges and Future Perspectives
COVID-19: Current Challenges and Future Perspectives Open
This Special Issue focuses on recent global research on the current coronavirus (COVID-19) pandemic [...]
View article: Trends in the prevalence of microscopically-confirmed schistosomiasis in the South African public health sector, 2011–2018
Trends in the prevalence of microscopically-confirmed schistosomiasis in the South African public health sector, 2011–2018 Open
Background Schistosomiasis, also known as bilharzia, is a chronic parasitic blood fluke infection acquired through contact with contaminated surface water. The illness may be mild or can cause significant morbidity with potentially serious…
View article: Improving the quality of malaria diagnosis in southern Africa through the development of a regional malaria slide bank
Improving the quality of malaria diagnosis in southern Africa through the development of a regional malaria slide bank Open
Background A malaria slide bank (MSB) is a useful asset for any malaria microscopy testing laboratory to have access to. However, it is not feasible for every country to have its own MSB. If countries are able to pool their resources, a re…
View article: <i>Anthemosoma garnhami</i> in an HIV-Infected Man from Zimbabwe Living in South Africa
<i>Anthemosoma garnhami</i> in an HIV-Infected Man from Zimbabwe Living in South Africa Open
An HIV-positive man from Zimbabwe living in South Africa sought treatment for multiple clinical signs, including fever, weight loss, anemia, and splenomegaly. We identified in his blood an African rodent piroplasm, Anthemosoma garnhami, re…
View article: Additional file 5 of Improving the quality of malaria diagnosis in southern Africa through the development of a regional malaria slide bank
Additional file 5 of Improving the quality of malaria diagnosis in southern Africa through the development of a regional malaria slide bank Open
Additional file 5. Costing for MSB set-up and annual MSB maintenance.
View article: Maintaining focus on administering effective malaria treatment during the COVID-19 pandemic
Maintaining focus on administering effective malaria treatment during the COVID-19 pandemic Open
As September marks the start of the malaria season in South Africa (SA), it is essential that healthcare professionals consider both COVID- 19 and malaria when a patient who lives in or has recently travelled to a malaria area presents wit…
View article: Anaplasma phagocytophilum and Other Anaplasma spp. in Various Hosts in the Mnisi Community, Mpumalanga Province, South Africa
Anaplasma phagocytophilum and Other Anaplasma spp. in Various Hosts in the Mnisi Community, Mpumalanga Province, South Africa Open
DNA samples from 74 patients with non-malarial acute febrile illness (AFI), 282 rodents, 100 cattle, 56 dogs and 160 Rhipicephalus sanguineus ticks were screened for the presence of Anaplasma phagocytophilum DNA using a quantitative PCR (q…
View article: Multi-locus sequence analyses reveal a clonal L. borgpetersenii genotype in a heterogeneous invasive Rattus spp. community across the City of Johannesburg, South Africa
Multi-locus sequence analyses reveal a clonal L. borgpetersenii genotype in a heterogeneous invasive Rattus spp. community across the City of Johannesburg, South Africa Open
Background Rattus spp. are frequently implicated as key reservoir hosts for leptospirosis, one of the most common, but neglected, bacterial zoonoses in the world. Although leptospirosis is predicted to be a significant public health threat…