John F. Burke
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View article: Pain catastrophizing and frailty in adult spinal deformity patients with cognitive impairment
Pain catastrophizing and frailty in adult spinal deformity patients with cognitive impairment Open
OBJECTIVE Cognitive impairment and pain catastrophizing are both associated with worse surgical outcomes. The aim of this study was to define the prevalence of cognitive impairment in patients with adult spinal deformity (ASD) and the rela…
View article: The CAMPUS Study: A Systems Approach to Alcohol-Involved Sexual Violence on College Campuses
The CAMPUS Study: A Systems Approach to Alcohol-Involved Sexual Violence on College Campuses Open
The collaborative model-building process successfully included diverse collaborator voices, integrating influential factors across multiple social-ecological levels. This iterative and capability-building approach can bridge intensive mode…
View article: Human Cervical Epidural Spinal Electrogram Topographically Maps Distinct Volitional Movements
Human Cervical Epidural Spinal Electrogram Topographically Maps Distinct Volitional Movements Open
Little is known about the electrophysiologic activity of the intact human spinal cord during volitional movement. We analyzed epidural spinal recordings from a total of five human subjects of both sexes during a variety of upper extremity …
View article: Leiomyogenic Tumor of the Spine: A Systematic Review
Leiomyogenic Tumor of the Spine: A Systematic Review Open
The study cohort consisted of 83 patients with a mean age of 49.55 (SD 13.72) with a female preponderance (60 patients). Here, 32.14% of patients had primary LTS; the remaining were metastases. Clinical presentation included nonspecific ba…
View article: WITHDRAWN: Epigenetic clocks and risk assessment in adult spinal deformity: A novel association between pace of aging with frailty, disability, and postoperative complications
WITHDRAWN: Epigenetic clocks and risk assessment in adult spinal deformity: A novel association between pace of aging with frailty, disability, and postoperative complications Open
Withdrawal statement The authors have withdrawn their manuscript owing to altered the findings and conclusions related to complication data. The changes in results were due to further scrutiny of the datasets, and led to the removal of 3 p…
View article: Patient Frailty Influences Outcome After Open, But Not Minimally Invasive, Transforaminal Interbody Fusion: A Case Series of 115 Patients With Lumbar Degenerative Disease
Patient Frailty Influences Outcome After Open, But Not Minimally Invasive, Transforaminal Interbody Fusion: A Case Series of 115 Patients With Lumbar Degenerative Disease Open
BACKGROUND: For transforaminal lumbar interbody fusion (TLIF), there are equally good open and minimally invasive surgery (MIS) options. OBJECTIVE: To determine if frailty has a differential effect on outcome for open vs MIS TLIF. METHODS:…
View article: A Prospective, Randomized, Controlled Comparison of Adhesive Wound Closure Devices in an Orthopaedic Patient
A Prospective, Randomized, Controlled Comparison of Adhesive Wound Closure Devices in an Orthopaedic Patient Open
Introduction: The objective of this study was to compare Zip and Clozex with a typical closure using a running 3-0 Prolene suture. Methods: A prospective, randomized, controlled trial was conducted in patients aged 18 years and older under…
View article: Do social determinants of health impact access to neurosurgical care in the United States? A workforce perspective
Do social determinants of health impact access to neurosurgical care in the United States? A workforce perspective Open
OBJECTIVE This study attempts to use neurosurgical workforce distribution to uncover the social determinants of health that are associated with disparate access to neurosurgical care. METHODS Data were compiled from public sources and aggr…
View article: Decision tree–based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury
Decision tree–based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury Open
OBJECTIVE Previous work has shown that maintaining mean arterial pressures (MAPs) between 76 and 104 mm Hg intraoperatively is associated with improved neurological function at discharge in patients with acute spinal cord injury (SCI). How…
View article: Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study
Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study Open
Spinal cord injuries (SCIs) frequently occur in combination with other major organ injuries, such as traumatic brain injury (TBI) and injuries to the chest, abdomen, and musculoskeletal system (e.g., extremity, pelvic, and spine fractures)…
View article: The tomb owner at the offering table: a pilot study on applying statistical analysis to dating Old Kingdom Memphite tombs
The tomb owner at the offering table: a pilot study on applying statistical analysis to dating Old Kingdom Memphite tombs Open
The (re-)construction of Old Kingdom Egypt requires a reasonable relative chronological framework, which has proven to be an elusive and often controversial endeavour. The analysis that has been done in tracing the evolution of tombs has i…
View article: Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury
Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury Open
In this cohort study, the incidence of self-reported PTE after TBI was found to be 2.8% and was independently associated with unfavorable outcomes. These findings highlight the need for effective antiepileptogenic therapies after TBI.
View article: Assessing and predicting neuropathic pain after spinal cord injury: a TRACK-SCI study
Assessing and predicting neuropathic pain after spinal cord injury: a TRACK-SCI study Open
Neuropathic pain is one of the most common secondary complications occurring after spinal cord injury (SCI), and often surpasses motor and sensory deficits in the patient population preferences of the most important aspects to be treated. …
View article: Use of Topical Vancomycin Powder to Reduce Surgical Site Infections after Deep Brain Stimulation Surgery: UCSF Experience and Meta-Analysis
Use of Topical Vancomycin Powder to Reduce Surgical Site Infections after Deep Brain Stimulation Surgery: UCSF Experience and Meta-Analysis Open
Objective: Surgical site infection (SSI) is the most common serious complication of deep brain stimulation (DBS) implantation surgery. Here, we report a single-surgeon experience on the efficacy of topical, intrawound vancomycin powder (VP…
View article: Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants
Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants Open
Little is known about the electrophysiological activity of the spinal cord during voluntary movement control in humans. We present a novel method for recording electrophysiological activity from the human spinal cord using implanted epidur…
View article: Telemedicine in Neurosurgery: Standardizing the Spinal Physical Examination Using A Modified Delphi Method
Telemedicine in Neurosurgery: Standardizing the Spinal Physical Examination Using A Modified Delphi Method Open
The resulting protocol was used in our clinic to standardize the telehealth strength examination. This protocol, as well as our summary of telehealth clinical practice, should aid neurosurgical clinics in integrating telemedicine modalitie…
View article: Diagnostic blood RNA profiles for human acute spinal cord injury
Diagnostic blood RNA profiles for human acute spinal cord injury Open
Diagnosis of spinal cord injury (SCI) severity at the ultra-acute stage is of great importance for emergency clinical care of patients as well as for potential enrollment into clinical trials. The lack of a diagnostic biomarker for SCI has…
View article: Theta Synchrony Is Increased near Neural Populations That Are Active When Initiating Instructed Movement
Theta Synchrony Is Increased near Neural Populations That Are Active When Initiating Instructed Movement Open
Theta oscillations (3-8 Hz) in the human brain have been linked to perception, cognitive control, and spatial memory, but their relation to the motor system is less clear. We tested the hypothesis that theta oscillations coordinate distrib…
View article: The COVID-19 Global Pandemic
The COVID-19 Global Pandemic Open
INTRODUCTION: The recent outbreak of a novel coronavirus illness (COVID-19) has grown into a global pandemic. As a response, there have been several treatment recommendations published by international, federal, state, and local governing …
View article: COVD-16. THE COVID-19 PANDEMIC FROM A NEURO-ONCOLOGY PERSPECTIVE: STRATEGIES, PROTOCOLS, AND LESSON LEARNED
COVD-16. THE COVID-19 PANDEMIC FROM A NEURO-ONCOLOGY PERSPECTIVE: STRATEGIES, PROTOCOLS, AND LESSON LEARNED Open
INTRODUCTION The COVID-19 pandemic has had an incalculable impact on our national healthcare system, and elective surgical procedures have been particularly affected. Given that brain tumors often straddle the line between elective and eme…
View article: Does state malpractice environment affect outcomes following spinal fusions? A robust statistical and machine learning analysis of 549,775 discharges following spinal fusion surgery in the United States
Does state malpractice environment affect outcomes following spinal fusions? A robust statistical and machine learning analysis of 549,775 discharges following spinal fusion surgery in the United States Open
OBJECTIVE Spine surgery is especially susceptible to malpractice claims. Critics of the US medical liability system argue that it drives up costs, whereas proponents argue it deters negligence. Here, the authors study the relationship betw…
View article: Consensus-based perioperative protocols during the COVID-19 pandemic
Consensus-based perioperative protocols during the COVID-19 pandemic Open
OBJECTIVE During the COVID-19 pandemic, quaternary-care facilities continue to provide care for patients in need of urgent and emergent invasive procedures. Perioperative protocols are needed to streamline care for these patients notwithst…
View article: Clamshell thoracotomy for en bloc resection of a 3-level thoracic chordoma: technical note and operative video
Clamshell thoracotomy for en bloc resection of a 3-level thoracic chordoma: technical note and operative video Open
The clamshell thoracotomy is often used to access both hemithoraxes and the mediastinum simultaneously for cardiothoracic pathology, but this technique is rarely used for the excision of spinal tumors. We describe the use of a clamshell th…
View article: Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics
Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics Open
OBJECTIVE Traumatic spinal cord injury (SCI) is a dreaded condition that can lead to paralysis and severe disability. With few treatment options available for patients who have suffered from SCI, it is important to develop prospective data…
View article: Blood RNA Profiles are Diagnostic for Severity in Human Acute Spinal Cord Injury
Blood RNA Profiles are Diagnostic for Severity in Human Acute Spinal Cord Injury Open
Biomarkers of spinal cord injury (SCI) could help determine the severity of the injury and facilitate early critical care decision making. We analyzed global gene expression in peripheral white blood cells during the acute injury phase and…
View article: Letter: The Coronavirus Disease 2019 Global Pandemic: A Neurosurgical Treatment Algorithm
Letter: The Coronavirus Disease 2019 Global Pandemic: A Neurosurgical Treatment Algorithm Open
To the Editor: The recent outbreak of a novel coronavirus illness (coronavirus disease 2019; COVID-19) has grown into a global pandemic. As a response, there have been several treatment recommendations published by international, federal, …
View article: AB064. Defining the genomic landscape of mucinous rectal cancer
AB064. Defining the genomic landscape of mucinous rectal cancer Open
Background: Mucinous adenocarcinoma (MA) accounts for 5–15% of rectal cancers. This histological subtype is known to have a poor response to neoadjuvant chemoradiotherapy and worse survival. Unlike MA of the colon there is little known abo…