Gary A. Cameron
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View article: Comparable long-term pain and disability outcomes following decompression alone versus decompression with fusion in lumbar spinal stenosis patients with high-signal facet joints
Comparable long-term pain and disability outcomes following decompression alone versus decompression with fusion in lumbar spinal stenosis patients with high-signal facet joints Open
Purpose This study aimed to evaluate the long-term outcomes of decompressive surgery with or without fusion in patients with lumbar spinal stenosis (LSS) exhibiting high-signal facet joints, a radiological marker of potential instability. …
View article: Machine learning identifies routine blood tests as accurate predictive measures of pollution-dependent poor cognitive function
Machine learning identifies routine blood tests as accurate predictive measures of pollution-dependent poor cognitive function Open
Background Several modifiable risk factors for dementia and related neurodegenerative diseases have been identified including education level, socio-economic status, and environmental exposures – however, how these population-level risks r…
View article: Gorse (Ulex europeaus) wastes with 5,6-dimethyl benzimidazole supplementation can support growth of vitamin B12 producing commensal gut microbes
Gorse (Ulex europeaus) wastes with 5,6-dimethyl benzimidazole supplementation can support growth of vitamin B12 producing commensal gut microbes Open
Many commensal gut microbes are recognized for their potential to synthesize vitamin B 12 , offering a promising avenue to address deficiencies through probiotic supplementation. While bioinformatics tools aid in predicting B 12 biosynthet…
View article: Gorse (<i>Ulex europeaus</i>) wastes with 5,6-dimethyl benzimidazole supplementation can support growth of vitamin B<sub>12</sub>producing commensal gut microbes
Gorse (<i>Ulex europeaus</i>) wastes with 5,6-dimethyl benzimidazole supplementation can support growth of vitamin B<sub>12</sub>producing commensal gut microbes Open
Many commensal gut microbes are recognized for their potential to synthesize vitamin B 12 , offering a promising avenue to address deficiencies through probiotic supplementation. While bioinformatics tools aid in predicting B 12 biosynthet…
View article: Glucose-enhanced oxidative stress resistance—A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection
Glucose-enhanced oxidative stress resistance—A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection Open
Most microbes have developed responses that protect them against stresses relevant to their niches. Some that inhabit reasonably predictable environments have evolved anticipatory responses that protect against impending stresses that are …
View article: Comprehensive Study of Antiretroviral Drug Permeability at the Cervicovaginal Mucosa via an In Vitro Model
Comprehensive Study of Antiretroviral Drug Permeability at the Cervicovaginal Mucosa via an In Vitro Model Open
Modulation of drug transporter activity at mucosal sites of HIV-1 transmission may be exploited to optimize retention of therapeutic antiretroviral drug concentrations at target submucosal CD4+ T cells. Previously, we showed that darunavir…
View article: Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient
Pharmacokinetic Profile of Plasma Levobupivacaine Following Fascia Iliaca Compartment Block for Proximal Femoral Fracture in Older Patient Open
Background: Fascia Iliaca Compartment Block (FICB) is commonly used in older patients to provide effective analgesia following hip fracture. Objectives: However, only limited Pharmacokinetic (PK) data about levobupivacaine are available to…
View article: Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB <sub>1</sub> Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in <i>Drosophila melanogaster</i>
Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB <sub>1</sub> Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in <i>Drosophila melanogaster</i> Open
Introduction: In mammals, sn-1-diacylglycerol lipases (DAGL) generate 2-arachidonoylglycerol (2-AG) that, as the major endocannabinoid, modulates synaptic neurotransmission by acting on CB1 cannabinoid receptors (CB1R). Even though the ins…
View article: Cyclic di-nucleotides – what is their role in biofilm formation and pathogenicity of Fusobacterium nucleatum?
Cyclic di-nucleotides – what is their role in biofilm formation and pathogenicity of Fusobacterium nucleatum? Open
Introduction Cyclic di-nucleotides (CDNs) act as important second messengers in bacteria, regulating multiple cellular functions, including biofilm formation. Fusobacterium nucleatum is a key player in disease-associated biofilms in period…
View article: Effects of repeated anaesthesia on gill and general health of Atlantic salmon, <scp><i>Salmo salar</i></scp>
Effects of repeated anaesthesia on gill and general health of Atlantic salmon, <span><i>Salmo salar</i></span> Open
Fish are the second most widely utilized vertebrate group used for scientific procedures in the United Kingdom, but the development and application of 3Rs (the principles of replacement, reduction, and refinement) in aquaculture disease re…
View article: Decreased sensitivity to aspirin is associated with altered polyamine metabolism in human prostate cancer cells
Decreased sensitivity to aspirin is associated with altered polyamine metabolism in human prostate cancer cells Open
Aspirin is a well-known analgesic, anti-inflammatory and antipyretic drug and is recognised as a chemopreventative agent in cardiovascular disease and, more recently, in colorectal cancer. Although several studies indicate that aspirin is …
View article: Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans
Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans Open
The major fungal pathogen of humans, Candida albicans, mounts robust responses to oxidative stress that are critical for its virulence. These responses counteract the reactive oxygen species (ROS) that are generated by host immune cells in…
View article: Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans
Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans Open
The major fungal pathogen of humans, Candida albicans, is exposed to reactive nitrogen and oxygen species following phagocytosis by host immune cells. In response to these toxins, this fungus activates potent anti-stress responses that inc…
View article: The enantioselective population pharmacokinetics of intravenous ketorolac in children using a stereoselective assay suitable for microanalysis
The enantioselective population pharmacokinetics of intravenous ketorolac in children using a stereoselective assay suitable for microanalysis Open
Objective To describe the effect of age and body size on enantiomer selective pharmacokinetic (PK) of intravenous ketorolac in children using a microanalytical assay. Methods Blood samples were obtained at 0, 15 and 30 min and at 1, 2, 4, …