John Geddes
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View article: Anthropomorphic technology in everyday life: focus on chatbots and impacts on mental health
Anthropomorphic technology in everyday life: focus on chatbots and impacts on mental health Open
View article: Cost-effectiveness of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression: Economic evaluation of the PAX-BD randomised controlled trial
Cost-effectiveness of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression: Economic evaluation of the PAX-BD randomised controlled trial Open
Pramipexole is a cost-effective treatment option for TRBD from the NHS + PSS perspective, with statistically significant increases in health-related quality of life and capability well-being over extended periods.
View article: Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression: a placebo-controlled, double-blind, randomised trial in the UK
Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression: a placebo-controlled, double-blind, randomised trial in the UK Open
National Institute of Health and Care Research, Efficacy and Mechanism Evaluation Programme.
View article: The value of mental science: we publish what matters
The value of mental science: we publish what matters Open
Summary Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its comm…
View article: 1096 Preparing Final Year Students for the Basic Management of Acute Surgical Patients Through High Fidelity Simulation
1096 Preparing Final Year Students for the Basic Management of Acute Surgical Patients Through High Fidelity Simulation Open
Aim This study aimed to design, implement, and evaluate a surgical simulation series to prepare 5th-year medical students for their final year, focusing on prioritising the management of unwell surgical patients on the ward. The sessions s…
View article: Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial
Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial Open
Background Lithium and several atypical antipsychotics are the recommended first-line augmentation options for treatment-resistant depression; however, few studies have compared them directly, and none for longer than 8 weeks. Consequently…
View article: Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial
Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial Open
Background There are limited options currently recommended in National Institute for Health and Care Excellence guidelines for the treatment of bipolar depression. Pramipexole has been shown to improve mood symptoms in two small pilot stud…
View article: Effect of lithium on circadian activity level and flexibility in patients with bipolar disorder: results from the Oxford Lithium Trial
Effect of lithium on circadian activity level and flexibility in patients with bipolar disorder: results from the Oxford Lithium Trial Open
View article: Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression: a pragmatic, open-label, parallel-group, randomised controlled superiority trial in the UK
Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression: a pragmatic, open-label, parallel-group, randomised controlled superiority trial in the UK Open
National Institute for Health and Care Research Health Technology Assessment programme.
View article: Reducing inequalities through greater diversity in clinical trials – As important for medical devices as for drugs and therapeutics
Reducing inequalities through greater diversity in clinical trials – As important for medical devices as for drugs and therapeutics Open
In medicine and public health, the randomised controlled trial (RCT) is generally considered the key generator of 'gold standard' evidence. However, basic and clinical research and trials are often unrepresentative of real-world population…
View article: Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment
Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment Open
View article: Identifying mood instability and circadian rest-activity patterns using digital remote monitoring and actigraphy in participants at risk for bipolar disorder
Identifying mood instability and circadian rest-activity patterns using digital remote monitoring and actigraphy in participants at risk for bipolar disorder Open
Mood instability and circadian rhythm disruptions are both of increasing interest with regard to a number of psychiatric disorders, notably bipolar disorder (BD), but understanding of their nature and their interrelationship are incomplete…
View article: A randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study)
A randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study) Open
Background: Options for ‘treatment-resistant bipolar depression’ (TRBD) are limited. Two small, short-term, trials of pramipexole suggest it might be an option. Aims: To evaluate the clinical effectiveness and safety of pramipexole in the …
View article: Lower Airway and Oral Microbiome Dysbiosis in Patients with Long COVID Post-Hospitalisation: A UK Multicentre, Prospective Cohort Study
Lower Airway and Oral Microbiome Dysbiosis in Patients with Long COVID Post-Hospitalisation: A UK Multicentre, Prospective Cohort Study Open
View article: Personality disorders, violence and antisocial behaviour: updated systematic review and meta-regression analysis
Personality disorders, violence and antisocial behaviour: updated systematic review and meta-regression analysis Open
Background Links between personality disorders and antisocial outcomes has not examined individual personality disorders, and the contribution of comorbidities remain uncertain. Previous systematic reviews are dated. Aims To synthesise evi…
View article: Ecological-Collective-Flourishing: A radical proposal for research and policy to develop and sustain human and environmental flourishing
Ecological-Collective-Flourishing: A radical proposal for research and policy to develop and sustain human and environmental flourishing Open
A growing body of research is connecting global environmental degradation to negative impacts on mental health and human flourishing. Meanwhile, international research and policy agendas are targeting the sustainable development of human h…
View article: Safety, tolerability, and efficacy outcomes of the Investigation of Levetiracetam in Alzheimer's disease (ILiAD) study: a pilot, double‐blind placebo‐controlled crossover trial
Safety, tolerability, and efficacy outcomes of the Investigation of Levetiracetam in Alzheimer's disease (ILiAD) study: a pilot, double‐blind placebo‐controlled crossover trial Open
Objective To assess whether the antiseizure medication levetiracetam may improve cognition in individuals with Alzheimer's disease who have not previously experienced a seizure. Methods We performed a randomized, double‐blind, placebo‐cont…
View article: Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK Open
View article: Differences between human and artificial/augmented intelligence in medicine
Differences between human and artificial/augmented intelligence in medicine Open
The emphasis on artificial intelligence (AI) is rapidly increasing across many diverse aspects of society. This manuscript discusses some of the key topics related to the expansion of AI. These include a comparison of the unique cognitive …
View article: Safety, tolerability and efficacy outcomes of the Investigation of Levetiracetam in Alzheimer’s Disease (ILiAD) trial
Safety, tolerability and efficacy outcomes of the Investigation of Levetiracetam in Alzheimer’s Disease (ILiAD) trial Open
Objective To assess whether the antiseizure medication levetiracetam may improve cognition in individuals with Alzheimer’s disease who have not previously experienced a seizure. Methods We performed a randomised, double-blind, placebo-cont…
View article: Co-design of ‘Ways of Being’, a web-based experience to optimise online arts and culture for mental health in young people
Co-design of ‘Ways of Being’, a web-based experience to optimise online arts and culture for mental health in young people Open
Aims and method We aimed to co-design an intervention optimising the benefits of online arts and culture for mental health in young people for subsequent testing in a trial. Co-design followed the double diamond phases of design, discover,…
View article: Violence in schizophrenia: triangulating the evidence on perpetration risk
Violence in schizophrenia: triangulating the evidence on perpetration risk Open
View article: An experimental medicine study of the effects of nicardipine on emotional processing in healthy volunteers with mood instability
An experimental medicine study of the effects of nicardipine on emotional processing in healthy volunteers with mood instability Open
View article: Future directions in the field of Bipolar Disorder
Future directions in the field of Bipolar Disorder Open
View article: Lithium Stabilises Circadian Activity While Enhancing its Flexibility in Patients with Bipolar Disorder: Results from the Oxford Lithium Trial
Lithium Stabilises Circadian Activity While Enhancing its Flexibility in Patients with Bipolar Disorder: Results from the Oxford Lithium Trial Open
View article: Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury
Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury Open
A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinnin…
View article: Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study Open
The Post-Hospitalisation COVID-19 (PHOSP-COVID) study is a national UK multicentre cohort study of patients who were hospitalized for COVID-19 and subsequently discharged.PHOSP-COVID was established to investigate the medium- and long-term…
View article: One year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study
One year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study Open
Background In patients with COVID-19 requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during acute C…
View article: Individual-level risk factors for suicide mortality in the general population: an umbrella review
Individual-level risk factors for suicide mortality in the general population: an umbrella review Open
Wellcome Trust.