Explanipedia

Projecting lifetime HIV-related healthcare costs for youth with HIV in the United States Open

Joshua Espada, Kunjal Patel, Clare Flanagan, Sarah E. Rutstein, John Giardina , et al. · 2025

We projected that US YHIV in care aged 13-24 years would incur nearly $17 billion in lifetime HIV-related healthcare costs. While total costs would increase with improved HIV-related care due to longer life expectancy, monthly costs would …

Estimating the effect of maternal viral load on perinatal and postnatal HIV transmission: a systematic review and meta-analysis Open

Caitlin M. Dugdale, Ogochukwu Ufio, John Giardina, Fatma M. Shebl, Elif Coskun , et al. · 2025

Cost-Effectiveness Analyses of Adolescent- and Young-Adult-Focused HIV Interventions Incorporating HIV Transmission: a Scoping Review of Modeling Methods and Proposed Guidance Open

Wanyi Chen, Simeng Li, Carol Mita, Sarah E. Rutstein, Audrey Pettifor , et al. · 2025

Lecanemab and Anticoagulants: Projected Effects on Health and Quality of Life Open

Sachin J. Shah, Tai Dinger, Deborah Blacker, Steven M. Greenberg, John Giardina , et al. · 2025

Background Lecanemab slows cognitive decline among people with early Alzheimer’s disease (early AD) but appears to increase the risk of intracranial hemorrhages (ICHs), including anticoagulant-related ICHs. Objective To examine the benefit…

Using Joint Longitudinal and Time-to-Event Models to Improve the Parameterization of Chronic Disease Microsimulation Models: an Application to Cardiovascular Disease Open

John Giardina, Sebastien Haneuse, Ankur Pandya · 2024

Background Chronic disease microsimulation models often simulate disease incidence as a function of risk factors that evolve over time (e.g., blood pressure increasing with age) in order to facilitate decision analyses of different disease…

Screening Strategies to Reduce COVID-19 Mortality in Nursing Homes Open

Shirley Dong, Eric Jutkowitz, John Giardina, Alyssa Bilinski · 2024

Importance Nursing home residents continue to bear a disproportionate share of COVID-19 morbidity and mortality, accounting for 9% of all US COVID-19 deaths in 2023, despite comprising only 0.4% of the population. Objective To evaluate the…

Integrating decision modeling and machine learning to inform treatment stratification Open

David Glynn, John Giardina, Julia Hatamyar, Ankur Pandya, Marta Soares , et al. · 2024

There is increasing interest in moving away from “one size fits all (OSFA)” approaches toward stratifying treatment decisions. Understanding how expected effectiveness and cost‐effectiveness varies with patient covariates is a key aspect o…

Estimated Transmission Outcomes and Costs of SARS-CoV-2 Diagnostic Testing, Screening, and Surveillance Strategies Among a Simulated Population of Primary School Students Open

Alyssa Bilinski, Andrea Ciaranello, Meagan C. Fitzpatrick, John Giardina, Maunank Shah , et al. · 2022

In this modeling study of a simulated population of primary school students and simulated transmission of COVID-19, test-to-stay policies and/or screening tests facilitated consistent in-person school attendance with low transmission risk …

Model-Estimated Association Between Simulated US Elementary School–Related SARS-CoV-2 Transmission, Mitigation Interventions, and Vaccine Coverage Across Local Incidence Levels Open

John Giardina, Alyssa Bilinski, Meagan C. Fitzpatrick, Emily A. Kendall, Benjamin P. Linas , et al. · 2022

Importance With recent surges in COVID-19 incidence and vaccine authorization for children aged 5 to 11 years, elementary schools face decisions about requirements for masking and other mitigation measures. These decisions require explicit…

Assessing the quality of shared decision making for elective orthopedic surgery across a large healthcare system: cross-sectional survey study Open

K. D. Valentine, Tom Cha, John Giardina, Felisha Marques, Steven J. Atlas , et al. · 2021

Model-estimated relationship between elementary school-related SARS-CoV-2 transmission, mitigation interventions, and vaccination coverage across community incidence levels Open

John Giardina, Alyssa Bilinski, Meagan C. Fitzpatrick, Emily A. Kendall, Benjamin P. Linas , et al. · 2021

Background While CDC guidance for K-12 schools recommends indoor masking regardless of vaccination status, final decisions about masking in schools will be made at the local and state level. The impact of the removal of mask restrictions, …

Passing the Test: A Model-Based Analysis of Safe School-Reopening Strategies Open

Alyssa Bilinski, Joshua A. Salomon, John Giardina, Andrea Ciaranello, Meagan C. Fitzpatrick · 2021

Centers for Disease Control and Prevention through the Council of State and Territorial Epidemiologists, National Institute of Allergy and Infectious Diseases, National Institute on Drug Abuse, and Facebook.

SARS-CoV-2 testing strategies to contain school-associated transmission: model-based analysis of impact and cost of diagnostic testing, screening, and surveillance Open

Alyssa Bilinski, Andrea Ciaranello, Meagan C. Fitzpatrick, John Giardina, Maunank Shah , et al. · 2021

Background In March 2021, the Biden administration allocated $10 billion for COVID-19 testing in schools. We evaluate the costs and benefits of testing strategies to reduce the infection risks of full-time in-person K-8 education at differ…

Passing the Test: A Model-based analysis of safe school-reopening strategies Open

Alyssa Bilinski, Joshua A. Salomon, John Giardina, Andrea Ciaranello, Meagan C. Fitzpatrick · 2021

Background The COVID-19 pandemic has induced historic educational disruptions. In December 2020, at least two-thirds of US public school students were not attending full-time in-person education. The Biden Administration has expressed that…

Additional file 2 of Assessing the quality of shared decision making for elective orthopedic surgery across a large healthcare system: cross-sectional survey study Open

K. D. Valentine, Tom Cha, John Giardina, Felisha Marques, Steven J. Atlas , et al. · 2021

Additional file 2.

Validation of an electronic coding algorithm to identify the primary indication of orthopedic surgeries from administrative data Open

John Giardina, Thomas Cha, Steven J. Atlas, Michael J. Barry, Andrew A. Freiberg , et al. · 2020

Defining high-value information for COVID-19 decision-making Open

Alyssa Bilinski, Ruthie Birger, Samantha Burn, Melanie H. Chitwood, Emma Clarke‐Deelder , et al. · 2020

Initial projections from the first generation of COVID-19 models focused public attention on worst-case scenarios in the absence of decisive policy action. These underscored the imperative for strong and immediate measures to slow the spre…

Replication Data for: Association Between Hospitals’ Engagement in Value-Based Reforms and Readmission Reduction in the Hospital Readmission Reduction Program by Ryan et al. Open