John H. Freeman
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View article: Interactions between the medial prefrontal cortex, dorsomedial striatum, and dorsal hippocampus that support rat category learning
Interactions between the medial prefrontal cortex, dorsomedial striatum, and dorsal hippocampus that support rat category learning Open
Categorization creates memory representations that are efficient, generalizable, and robust to noise. Multiple brain regions have been implicated in categorization, including the prefrontal cortex, striatum, and hippocampus; however, few s…
View article: Dissociable Roles of the Dorsolateral and Ventromedial Prefrontal Cortex in Human Categorization
Dissociable Roles of the Dorsolateral and Ventromedial Prefrontal Cortex in Human Categorization Open
Models of human categorization predict the prefrontal cortex (PFC) serves a central role in category learning. The dorsolateral prefrontal cortex (dlPFC) and ventromedial prefrontal cortex (vmPFC) have been implicated in categorization; ho…
View article: Automated device for simultaneous photometry and electrophysiology in freely moving animals
Automated device for simultaneous photometry and electrophysiology in freely moving animals Open
Photometry and electrophysiology are powerful tools for investigating brain-behavior relationships. Combining these techniques would allow us to ask previously un-addressable questions, such as how neuromodulators impact neuronal firing ra…
View article: Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning
Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning Open
Communication between the cerebellum and forebrain structures is necessary for motor learning and has been implicated in a variety of cognitive functions. The exact nature of cerebellar–forebrain interactions supporting behavior and cognit…
View article: Disruption of the non-canonical wnt gene PRICKLE2 leads to cerebellar Purkinje cell abnormalities while cerebellar-mediated behaviors remain intact.
Disruption of the non-canonical wnt gene PRICKLE2 leads to cerebellar Purkinje cell abnormalities while cerebellar-mediated behaviors remain intact. Open
Autism spectrum disorders (ASD) involve brain wide abnormalities that contribute to a constellation of symptoms including behavioral inflexibility, cognitive dysfunction, learning impairments, altered social interactions, and perceptive ti…
View article: Dorsomedial striatum, but not dorsolateral striatum, is necessary for rat category learning
Dorsomedial striatum, but not dorsolateral striatum, is necessary for rat category learning Open
Categorization is an adaptive cognitive function that allows us to generalize knowledge to novel situations. Converging evidence from neuropsychological, neuroimaging, and neurophysiological studies suggest that categorization is mediated …
View article: The dorsal hippocampus’ role in context-based timing in rodents
The dorsal hippocampus’ role in context-based timing in rodents Open
To act proactively, we must predict when future events will occur. Individuals generate temporal predictions using cues that indicate an event will happen after a certain duration elapses. Neural models of timing focus on how the brain rep…
View article: Theta oscillations in rat infralimbic cortex are associated with the inhibition of cocaine seeking during extinction
Theta oscillations in rat infralimbic cortex are associated with the inhibition of cocaine seeking during extinction Open
Infralimbic cortical (IL) manipulations indicate that this region mediates extinction learning and suppresses cocaine seeking following cocaine self‐administration. However, little work has recorded IL activity during the inhibition of coc…
View article: Disruption of cerebellar maturation by an antimitotic agent impairs the ontogeny of eyeblink conditioning in rats
Disruption of cerebellar maturation by an antimitotic agent impairs the ontogeny of eyeblink conditioning in rats Open
This study represents an attempt to establish a relationship between maturation of the cerebellum and the ontogeny of eyeblink conditioning in the rat. Experiments 1 and 2 examined the effects of disrupting cerebellar maturation by neonata…
View article: Communication between the mediodorsal thalamus and prelimbic cortex regulates timing performance in rats
Communication between the mediodorsal thalamus and prelimbic cortex regulates timing performance in rats Open
Predicting when future events will occur and adjusting behavior accordingly is critical to adaptive behavior. Despite this, little is known about the brain networks that encode time and how this ultimately impacts decision-making. One esta…
View article: Factors influencing developmental differences in retention of Pavlovian fear conditioning.
Factors influencing developmental differences in retention of Pavlovian fear conditioning. Open
Modern nonhuman animal research on the rapid forgetting of memories formed early in life-often termed "infantile amnesia"-has focused on neurobiological changes occurring between learning and retention testing to explain age differences in…
View article: Amygdala central nucleus modulation of cerebellar learning in female rats.
Amygdala central nucleus modulation of cerebellar learning in female rats. Open
Previous studies found that inactivation of the central amygdala (CeA) severely impaired acquisition of cerebellum-dependent delay eye-blink conditioning (EBC) in male rats and rabbits. Sex differences in EBC and the effects of stress on E…
View article: Category learning in rodents using touchscreen‐based tasks
Category learning in rodents using touchscreen‐based tasks Open
Categorization is a fundamental cognitive function that organizes our experiences into meaningful “chunks.” This category knowledge can then be generalized to novel stimuli and situations. Multiple clinical populations, including people wi…
View article: Selective attention in rat visual category learning
Selective attention in rat visual category learning Open
A prominent theory of category learning, COVIS, posits that new categories are learned with either a declarative or procedural system, depending on the task. The declarative system uses the prefrontal cortex (PFC) to learn rule-based (RB) …
View article: Decision letter: Cerebellar implementation of movement sequences through feedback
Decision letter: Cerebellar implementation of movement sequences through feedback Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Most movements are not unitar…
View article: Dorsal hippocampus is necessary for visual categorization in rats
Dorsal hippocampus is necessary for visual categorization in rats Open
The hippocampus may play a role in categorization because of the need to differentiate stimulus categories (pattern separation) and to recognize category membership of stimuli from partial information (pattern completion). We hypothesized …
View article: Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning
Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning Open
Although evidence suggests that the basolateral amygdala (BLA) and dorsal hippocampus (DH) work together to influence the consolidation of spatial/contextual learning, the circuit mechanism by which the BLA selectively modulates spatial/co…
View article: Memory consolidation within the central amygdala is not necessary for modulation of cerebellar learning
Memory consolidation within the central amygdala is not necessary for modulation of cerebellar learning Open
Amygdala lesions impair, but do not prevent, acquisition of cerebellum-dependent eyeblink conditioning suggesting that the amygdala modulates cerebellar learning. Two-factor theories of eyeblink conditioning posit that a fast-developing me…
View article: Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning
Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning Open
Hippocampal development is thought to play a crucial role in the emergence of many forms of learning and memory, but ontogenetic changes in hippocampal activity during learning have not been examined thoroughly. We examined the ontogeny of…