Kenton J. Hetrick
YOU?
Author Swipe
View article: Assessing and utilizing esterase specificity in antimicrobial prodrug development
Assessing and utilizing esterase specificity in antimicrobial prodrug development Open
View article: Endogenous Enzymes Enable Antimicrobial Activity
Endogenous Enzymes Enable Antimicrobial Activity Open
In light of the continued threat of antimicrobial-resistant bacteria, new strategies to expand the repertoire of antimicrobial compounds are necessary. Prodrugs are an underexploited strategy in this effort. Here, we report on the enhanced…
View article: Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family
Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family Open
Background Lanthipeptides belong to the ribosomally synthesized and post-translationally modified peptide group of natural products and have a variety of biological activities ranging from antibiotics to antinociceptives. These peptides ar…
View article: Additional file 2 of Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family
Additional file 2 of Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family Open
Additional file 2. Excel File containing precursor peptides identified in this study.
View article: Additional file 3 of Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family
Additional file 3 of Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family Open
Additional file 3. Custom HMM for LanKC LanC-like domains.
View article: Additional file 4 of Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family
Additional file 4 of Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family Open
Additional file 4. Custom HMM for LanL LanC-like domains.
View article: Terbium(III) Luminescence-Based Assay for Esterase Activity
Terbium(III) Luminescence-Based Assay for Esterase Activity Open
Esterases catalyze the hydrolysis of esters to form a carboxylic acid and alcohol. These enzymes play a key role in both the detoxification of xenobiotic compounds and the metabolism of drugs and prodrugs. Numerous fluorogenic probes have …
View article: Terbium(III) Luminescence-Based Assay for Esterase Activity
Terbium(III) Luminescence-Based Assay for Esterase Activity Open
Esterases\ncatalyze the hydrolysis of esters to form a carboxylic\nacid and alcohol. These enzymes play a key role in both the detoxification\nof xenobiotic compounds and the metabolism of drugs and prodrugs.\nNumerous fluorogenic probes h…
View article: Development of lanthipeptide engineering strategies
Development of lanthipeptide engineering strategies Open
Natural products have long been an important source of therapeutic compounds. The lanthipeptides, members of the ribosomally synthesized and post-translationally modified peptide class of natural products, have potential applications rangi…
View article: Development and Application of Yeast and Phage Display of Diverse Lanthipeptides
Development and Application of Yeast and Phage Display of Diverse Lanthipeptides Open
Peptide display has enabled identification and optimization of ligands to many targets. These ligands are usually linear or disulfide-containing peptides that are vulnerable to proteolysis or reduction. We report yeast surface and phage di…
View article: Characterization of Leader Peptide Binding During Catalysis by the Nisin Dehydratase NisB
Characterization of Leader Peptide Binding During Catalysis by the Nisin Dehydratase NisB Open
The dehydratase NisB performs stepwise tRNAGlu-dependent glutamylation of Ser/Thr residues and subsequent glutamate elimination to effect eight dehydrations in the biosynthesis of the antibacterial peptide nisin. Its substrate, …
View article: Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era
Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era Open