John H. Shin
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View article: Hemopurifier device in patients with solid tumours who have stable or progressive disease while on a treatment that includes pembrolizumab or nivolumab: protocol for an Australian safety, feasibility and dose-finding study
Hemopurifier device in patients with solid tumours who have stable or progressive disease while on a treatment that includes pembrolizumab or nivolumab: protocol for an Australian safety, feasibility and dose-finding study Open
Background Immunotherapy with anti-programmed cell death protein 1 (anti-PD-1) inhibitors has revolutionised the treatment of many solid tumours, however, only 30–40% of patients will have a lasting clinical response. Tumour-derived extrac…
View article: Association Between Nutritional Status and Survival in Patients Requiring Treatment for Spinal Metastases
Association Between Nutritional Status and Survival in Patients Requiring Treatment for Spinal Metastases Open
BACKGROUND AND OBJECTIVES: The Patient-Generated Subjective Global Assessment (PG-SGA) is a standardized tool for assessing malnutrition in patients with cancer. The primary aim of this study was to assess the impact of preoperative nutrit…
View article: Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy
Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy Open
Acquired resistance to immune checkpoint inhibitors (ICIs) remains a significant challenge in the treatment of metastatic melanoma. Phenotypic plasticity, such as dedifferentiation and transdifferentiation, is an increasingly recognized me…
View article: Preoperative Function, Previous SERM Treatment, and Triple-Negative Tumor Status are Independently Associated With 3-Month Postoperative Function After Surgical Decompression of Metastatic Breast Cancer
Preoperative Function, Previous SERM Treatment, and Triple-Negative Tumor Status are Independently Associated With 3-Month Postoperative Function After Surgical Decompression of Metastatic Breast Cancer Open
Background: The most common cancer in women worldwide, breast cancer most often metastasizes to the bone. Improved chemo- and radiotherapies and novel molecular therapies have prolonged survival in women with osseous metastatic breast canc…
View article: Association of Osteoporosis and Bone-Strengthening Medications with Postoperative Outcomes Following Transforaminal Lumbar Interbody Fusion
Association of Osteoporosis and Bone-Strengthening Medications with Postoperative Outcomes Following Transforaminal Lumbar Interbody Fusion Open
Osteoporosis is linked to higher reoperation and medical complications following lumbar fusion. Although osteoporosis medications did not significantly alter reoperation risk, their potential role in perioperative optimization requires fur…
View article: Impact of prediabetes on postoperative outcomes following short-segment transforaminal lumbar interbody fusions
Impact of prediabetes on postoperative outcomes following short-segment transforaminal lumbar interbody fusions Open
T2DM is associated with a higher risk of medical and surgical complications following short-segment TLIF. However, prediabetes does not appear to affect postoperative complication rates. These findings suggest enhanced perioperative manage…
View article: E-cigarette Vaping is Associated with Pro-Fibrotic Gene Expression in Kidney and Liver Tissues
E-cigarette Vaping is Associated with Pro-Fibrotic Gene Expression in Kidney and Liver Tissues Open
Conventional tobacco use causes a wealth of diseases and adversely affects cells and organ systems across the body. The long-term effects of e-cigarette vaping on the same remain unclear and identifying early pathogenic signals at the orga…
View article: An International Delphi Consensus on Defining the Optimal Surgical Composite Outcome in Metastatic Spine Disease
An International Delphi Consensus on Defining the Optimal Surgical Composite Outcome in Metastatic Spine Disease Open
Study Design. Delphi consensus. Objective. To define an optimal surgical composite outcome measure in patients with metastatic spine disease (OSCO-M) through international consensus among key opinion leaders. Materials and Methods. Members…
View article: Application of deformity principles in the management of spinal neoplasms: A Primer
Application of deformity principles in the management of spinal neoplasms: A Primer Open
The potential negative impact of spinal deformity on patient quality of life in the spinal oncology population is now better appreciated amongst spinal oncologists, but studies have been limited to date. Further investigation is merited as…
View article: An Appraisal of the Quality of Development and Reporting of Predictive Models in Spine Surgery
An Appraisal of the Quality of Development and Reporting of Predictive Models in Spine Surgery Open
Study Design Literature review. Objective The Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD) statement was developed to improve the generalizability of predictive models. This study…
View article: The impact of semaglutide use for weight loss on transforaminal lumbar interbody fusion outcomes
The impact of semaglutide use for weight loss on transforaminal lumbar interbody fusion outcomes Open
Semaglutide may adversely affect lumbar fusion outcomes and necessitate additional surgery, possibly secondary to its systemic effects on bone metabolism and weight loss patterns. Further research into optimal drug formulation, dosage, and…
View article: Surgical Adverse Events for Primary Tumors of the Spine and Their Impact on Outcomes: An Observational Study From the Primary Tumors Research and Outcomes Network
Surgical Adverse Events for Primary Tumors of the Spine and Their Impact on Outcomes: An Observational Study From the Primary Tumors Research and Outcomes Network Open
BACKGROUND AND OBJECTIVES: Aggressive resection for primary tumors of the spine are associated with a high rate of adverse events (AEs), but the impact of AEs on patient-reported outcomes (PROs) remains unknown and is critical to the share…
View article: Comparison of Outcomes Between Staged and Same-Day Circumferential Spinal Fusion for Adult Spinal Deformity: Systematic Review and Meta-Analysis
Comparison of Outcomes Between Staged and Same-Day Circumferential Spinal Fusion for Adult Spinal Deformity: Systematic Review and Meta-Analysis Open
Background Adult spinal deformity (ASD) is a prevalent condition often treated with circumferential spinal fusion (CF), which can be performed as staged or same-day procedures. However, evidence guiding the choice between these approaches …
View article: Prevention and Management of Posterior Wound Complications Following Oncologic Spine Surgery: Narrative Review of Available Evidence and Proposed Clinical Decision-Making Algorithm
Prevention and Management of Posterior Wound Complications Following Oncologic Spine Surgery: Narrative Review of Available Evidence and Proposed Clinical Decision-Making Algorithm Open
Study Design Narrative Review. Objective Contextualized by a narrative review of recent literature, we propose a wound complication prevention and management algorithm for spinal oncology patients. We highlight available strategies and mot…
View article: A Critical Appraisal of the Application of Frailty and Sarcopenia in the Spinal Oncology Population
A Critical Appraisal of the Application of Frailty and Sarcopenia in the Spinal Oncology Population Open
Study Design Systematic review and clinimetric analysis. Objectives Frailty and sarcopenia predict worse surgical outcomes among spinal degenerative and deformity-related populations; this association is less clear in the context of spinal…
View article: Overview of Molecular Prognostication for Common Solid Tumor Histologies – What the Surgeon Should Know
Overview of Molecular Prognostication for Common Solid Tumor Histologies – What the Surgeon Should Know Open
Study design Narrative Literature review. Objective To provide a general overview of important molecular markers and targeted therapies for the most common neoplasms (lung, breast, prostate and melanoma) that metastasize to the spine and o…
View article: Role of Posterior Carbon Fiber Implants in Spine Tumor Surgery
Role of Posterior Carbon Fiber Implants in Spine Tumor Surgery Open
Study Design Narrative Review. Objective The management of spinal tumors requires a multi-disciplinary approach including surgery, radiation, and systemic therapy. Surgical approaches typically require posterior segmental instrumentation t…
View article: What is the Optimal Management of Metastatic Spine Patients With Intermediate Spinal Instability Neoplastic Scores: To Operate or Not to Operate?
What is the Optimal Management of Metastatic Spine Patients With Intermediate Spinal Instability Neoplastic Scores: To Operate or Not to Operate? Open
Study Design Systematic review. Objective In patients with extradural metastatic spine disease, we sought to systematically review the outcomes and complications of patients with intermediate Spinal Instability Neoplastic Score (SINS) lesi…
View article: Comparison of Outcomes Between Staged and Same-Day Circumferential Spinal Fusion for Adult Spinal Deformity: Systematic Review and Meta-Analysis (Preprint)
Comparison of Outcomes Between Staged and Same-Day Circumferential Spinal Fusion for Adult Spinal Deformity: Systematic Review and Meta-Analysis (Preprint) Open
BACKGROUND Adult spinal deformity (ASD) is a prevalent condition often treated with circumferential spinal fusion (CF), which can be performed as staged or same-day procedures. However, evidence guiding the choice between these approaches…
View article: 6782 The Myth of MARD: Limitations Of The Mean Absolute Relative Difference In The Analytical And Clinical Assessment Of Continuous Glucose Monitoring (CGM)
6782 The Myth of MARD: Limitations Of The Mean Absolute Relative Difference In The Analytical And Clinical Assessment Of Continuous Glucose Monitoring (CGM) Open
Disclosure: R.A. Vigersky: Employee; Self; Medtronic Diabetes. Stock Owner; Self; Medtronic Diabetes. T.L. Cordero: Employee; Self; Medtronic Diabetes. Stock Owner; Self; Medtronic Diabetes. J. Shin: Employee; Self; Medtronic Diabetes. Sto…
View article: Predictors of Clavien–Dindo Grade III–IV or Grade V Complications after Metastatic Spinal Tumor Surgery: An Analysis of Sociodemographic, Socioeconomic, Clinical, Oncologic, and Operative Parameters
Predictors of Clavien–Dindo Grade III–IV or Grade V Complications after Metastatic Spinal Tumor Surgery: An Analysis of Sociodemographic, Socioeconomic, Clinical, Oncologic, and Operative Parameters Open
The rate of major complications and 30-day mortality after surgery for metastatic spinal tumors is relatively high. While most studies have focused on baseline comorbid conditions and operative parameters as risk factors, there is limited …
View article: CohortFinder: an open-source tool for data-driven partitioning of digital pathology and imaging cohorts to yield robust machine-learning models
CohortFinder: an open-source tool for data-driven partitioning of digital pathology and imaging cohorts to yield robust machine-learning models Open
Batch effects (BEs) refer to systematic technical differences in data collection unrelated to biological variations whose noise is shown to negatively impact machine learning (ML) model generalizability. Here we release CohortFinder ( http…
View article: Unraveling molecular advancements in chordoma tumorigenesis and treatment response: a review of scientific discoveries and clinical implications
Unraveling molecular advancements in chordoma tumorigenesis and treatment response: a review of scientific discoveries and clinical implications Open
Chordomas are tumors thought to originate from notochordal remnants that occur in midline structures from the cloves of the skull base to the sacrum. In adults, the most common location is the sacrum, followed by the clivus and then mobile…
View article: The Impact of Peri-operative Enhanced Recovery After Surgery Protocols on Outcomes Following Adult Cervical Deformity Surgery
The Impact of Peri-operative Enhanced Recovery After Surgery Protocols on Outcomes Following Adult Cervical Deformity Surgery Open
Study Design Retrospective cohort study. Objectives To assess the impact of Enhanced recovery after surgery (ERAS) protocols on peri-operative course in adult cervical deformity (ACD) corrective surgery. Methods Patients ≥18 yrs with compl…