John D. Van Horn
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View article: Harnessing Trial-to-Trial Variability of EEG Spectral Characteristics to Understand Autism
Harnessing Trial-to-Trial Variability of EEG Spectral Characteristics to Understand Autism Open
By incorporating neural variability into machine learning models, this study introduces a novel framework for improving biomarker-driven assessments. These findings highlight the potential for personalized tools that inform targeted interv…
View article: Diffusion <scp>MRI</scp> Microstructure Markers of Changes in the Human Brain Across the Lifespan Using Constrained Spherical Deconvolution and Fixel‐Based Techniques
Diffusion <span>MRI</span> Microstructure Markers of Changes in the Human Brain Across the Lifespan Using Constrained Spherical Deconvolution and Fixel‐Based Techniques Open
Understanding how the brain develops, matures, ages, and declines is one of the fundamental questions facing neuroscience. This study uses 3‐tissue constrained spherical deconvolution (3T‐CSD) and more recently developed fixel‐based deriva…
View article: Brain morphology network alterations in adolescents with autism spectrum disorder: a sex-stratified study
Brain morphology network alterations in adolescents with autism spectrum disorder: a sex-stratified study Open
Background One of the most persistent questions in autism research is why males are more consistently diagnosed than females. Neuroimaging studies have sought to understand this disparity by examining sex differences, primarily through fun…
View article: A Systematic Review of Female Athletes in Concussion Research: Gaps, Findings, and Future Directions
A Systematic Review of Female Athletes in Concussion Research: Gaps, Findings, and Future Directions Open
Background Despite the growing participation of female athletes in contact and high-impact sports, their representation in concussion research remains disproportionately low. This imbalance limits the generalizability of clinical guideline…
View article: Structural determinants of signal speed: Estimated axonal latency and its multimodal validation during face processing in autism
Structural determinants of signal speed: Estimated axonal latency and its multimodal validation during face processing in autism Open
It has not previously been possible to investigate the fundamental relationship between axonal structure – which dictates action potential transmission – and human neuronal function in vivo . Here, we introduce a novel metric of axonal sig…
View article: The NTU-DSI-122 template as a flexible platform for fiber orientation distribution registration of diffusion microstructure into stereotaxic space
The NTU-DSI-122 template as a flexible platform for fiber orientation distribution registration of diffusion microstructure into stereotaxic space Open
The registration of neuroimaging subjects to a common stereotaxic space allows for comparisons between timepoints, subjects, or with reference atlases of regions of interest. Typically, this has been performed by computing a similarity met…
View article: Diffusion MRI microstructure markers of changes in the human brain across the lifespan
Diffusion MRI microstructure markers of changes in the human brain across the lifespan Open
Understanding how the brain develops, matures, ages, and declines is one of the fundamental questions facing neuroscience. Recent advances in diffusion MRI microstructure analysis have allowed for detailed descriptions of neuronal change i…
View article: Revealing Gender Differences in Concussion Reporting: A Detailed Analysis of SCAT Assessment Self-Report Symptom Ratings
Revealing Gender Differences in Concussion Reporting: A Detailed Analysis of SCAT Assessment Self-Report Symptom Ratings Open
Current concussion assessments used by the NCAA are typically applied across both male and female athletes to assess the effects of sports-related head impacts. However, increasing evidence suggests that female athletes exhibit different p…
View article: Widespread associations between behavioral metrics and brain microstructure in ASD suggest age mediates subtypes of ASD
Widespread associations between behavioral metrics and brain microstructure in ASD suggest age mediates subtypes of ASD Open
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by differences in social communication and repetitive behaviors. Our laboratory has previously found that g-ratio, the proportion of axon width to myelin diamete…
View article: Diffusion Signals of Glial Activation Correlate with Fitness Scores in Parkinson’s Subcortical Gray Matter
Diffusion Signals of Glial Activation Correlate with Fitness Scores in Parkinson’s Subcortical Gray Matter Open
The cholinergic basal forebrain and subcortical gray matter have previously been implicated in Parkinson’s disease (PD) but the relationship between the symptomology of PD, including cognitive impairment, and specific patterns of damage re…
View article: Unsupervised Dimensionality Reduction Techniques for the Assessment of ASD Biomarkers
Unsupervised Dimensionality Reduction Techniques for the Assessment of ASD Biomarkers Open
Autism Spectrum Disorder (ASD) encompasses a range of developmental disabilities marked by differences in social functioning, cognition, and behavior. Both genetic and environmental factors are known to contribute to ASD, yet the exact eti…
View article: Leveraging multi-site electronic health data for characterization of subtypes: a pilot study of dementia in the N3C Clinical Tenant
Leveraging multi-site electronic health data for characterization of subtypes: a pilot study of dementia in the N3C Clinical Tenant Open
Objectives To provide a foundational methodology for differentiating comorbidity patterns in subphenotypes through investigation of a multi-site dementia patient dataset. Materials and Methods Employing the National Clinical Cohort Collabo…
View article: High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease
High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease Open
Background Pathologic perivascular spaces (PVS), the fluid‐filled compartments surrounding brain vasculature, may underlie cognitive decline in Parkinson's disease (PD). However, whether this impacts specific cognitive domains has not been…
View article: The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives
The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives Open
Background Most children with Autism Spectrum Disorder (ASD) have co-occurring language impairments and some of these autism-specific language difficulties are also present in their non-autistic first-degree relatives. One of the possible …
View article: Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder
Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder Open
The neuronal differences contributing to the etiology of autism spectrum disorder (ASD) are still not well defined. Previous studies have suggested that myelin and axons are disrupted during development in ASD. By combining structural and …
View article: Gender Biases In Sports Concussions: A Differential Item Functioning Analysis into NCAA Female Athlete Symptom Presentation and Validity of the SCAT3 Checklist
Gender Biases In Sports Concussions: A Differential Item Functioning Analysis into NCAA Female Athlete Symptom Presentation and Validity of the SCAT3 Checklist Open
Background As a consequence of sports-related concussions, female athletes have been documented as reporting more symptoms than their male counterparts, in addition to incurring longer periods of recovery. However, the role of gender and i…
View article: Biophysical modulation and robustness of itinerant complexity in neuronal networks
Biophysical modulation and robustness of itinerant complexity in neuronal networks Open
Transient synchronization of bursting activity in neuronal networks, which occurs in patterns of metastable itinerant phase relationships between neurons, is a notable feature of network dynamics observed in vivo . However, the mechanisms …
View article: Assessment of Sports Concussion in Female Athletes: A Role for Neuroinformatics?
Assessment of Sports Concussion in Female Athletes: A Role for Neuroinformatics? Open
Over the past decade, the intricacies of sports-related concussions among female athletes have become readily apparent. Traditional clinical methods for diagnosing concussions suffer limitations when applied to female athletes, often faili…
View article: Increased perivascular space volume in white matter and basal ganglia is associated with cognition in Parkinson’s Disease
Increased perivascular space volume in white matter and basal ganglia is associated with cognition in Parkinson’s Disease Open
Perivascular spaces (PVS), fluid-filled compartments surrounding brain vasculature, are an essential component of the glymphatic system responsible for transport of waste and nutrients. Glymphatic system impairment may underlie cognitive d…
View article: Frontal <scp>EEG</scp> alpha asymmetry in youth with autism: Sex differences and social–emotional correlates
Frontal <span>EEG</span> alpha asymmetry in youth with autism: Sex differences and social–emotional correlates Open
In youth broadly, EEG frontal alpha asymmetry (FAA) associates with affective style and vulnerability to psychopathology, with relatively stronger right activity predicting risk for internalizing and externalizing behaviors. In autistic yo…
View article: Linking Symptom Inventories using Semantic Textual Similarity
Linking Symptom Inventories using Semantic Textual Similarity Open
An extensive library of symptom inventories has been developed over time to measure clinical symptoms, but this variety has led to several long standing issues. Most notably, results drawn from different settings and studies are not compar…
View article: Conduction Velocity, G-ratio, and Extracellular Water as Microstructural Characteristics of Autism Spectrum Disorder
Conduction Velocity, G-ratio, and Extracellular Water as Microstructural Characteristics of Autism Spectrum Disorder Open
The neuronal differences contributing to the etiology of autism spectrum disorder (ASD) are still not well defined. Previous studies have suggested that myelin and axons are disrupted during development in ASD. By combining structural and …
View article: Modulating Factors Affecting Sports-Related Concussion Exposures: A Systematic Review and Analysis
Modulating Factors Affecting Sports-Related Concussion Exposures: A Systematic Review and Analysis Open
In the United States, the Centers for Disease Control and Prevention estimates that 1.6-to-3.8 million concussions occur annually in sports. This quantitative meta-analysis of one hundred and twenty-one sports-related concussion studies, a…