Explanipedia

TRACE-seq: A transgenic system for unbiased and non-invasive transcriptome profiling of living cells Open

François Cherbonneau, Guoping Li, Priyanka Gokulnath, Parul Sahu, Aurore Prunevieille , et al. · 2022

TRACE-Seq: A Transgenic System for Unbiased Loading of mRNA into Extracellular Vesicles Allowing Non-Invasive Transcriptome Profiling of Living Cells Open

François Cherbonneau, Aurore Prunevieille, Robert R. Kitchen, Gilles Bénichou, Jérôme Larghero , et al. · 2021

Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle Open

Abir Yamak, Dongjian Hu, Nikhil Mittal, Jan W Buikema, Sheraz Ditta , et al. · 2020

Defining the pathways that control cardiac development facilitates understanding the pathogenesis of congenital heart disease. Herein, we identify enrichment of a Cullin5 Ub ligase key subunit, Asb2, in myocardial progenitors and different…

Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity Open

Ayhan Atmanli, Dongjian Hu, Frederik E. Deiman, Annebel Marjolein van de Vrugt, François Cherbonneau , et al. · 2019

A fundamental goal in the biological sciences is to determine how individual cells with varied gene expression profiles and diverse functional characteristics contribute to development, physiology, and disease. Here, we report a novel stra…

Author response: Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity Open

Ayhan Atmanli, Dongjian Hu, Frederik E. Deiman, Annebel Marjolein van de Vrugt, François Cherbonneau , et al. · 2019

Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA Open

Dongjian Hu, Annet N. Linders, Abir Yamak, Cláudia Correia, Jan David Kijlstra , et al. · 2018

Rationale: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are a readily available, robustly reproducible, and physiologically appropriate human cell source for cardiac disease modeling, drug discovery, and toxicity screening…

Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells Open

Oriol Bover, Tiago Justo, Paulo N. G. Pereira, João Facucho-Oliveira, José M. Inácio , et al. · 2018

Understanding the molecular pathways regulating cardiogenesis is crucial for the early diagnosis of heart diseases and improvement of cardiovascular disease. During normal mammalian cardiac development, collagen and calcium-binding EGF dom…

MicroRNA-425 and microRNA-155 cooperatively regulate atrial natriuretic peptide expression and cGMP production Open

Sara Vandenwijngaert, Clara D. Ledsky, Obiajulu Agha, Connie Wu, Dongjian Hu , et al. · 2018

These data demonstrate that miR-425 and miR-155 regulate NPPA expression in a cooperative manner. Targeting both miRNAs with anti-miRs (possibly at submaximal concentrations) might prove to be a more effective strategy to modulate ANP leve…

Biotechnology and Bioengineering: Volume 115, Number 3, March 2018 Open

Cheng Zhu, Łukasz Pepłowski, Wei Cui, Yi Xia, Zhi Liu , et al. · 2018

Novel Mutation in <i>FLNC</i> (Filamin C) Causes Familial Restrictive Cardiomyopathy Open

Nathan R. Tucker, Micheal A. McLellan, Dongjian Hu, Jiangchuan Ye, Victoria A. Parsons , et al. · 2017

Background— Restrictive cardiomyopathy (RCM) is a rare cardiomyopathy characterized by impaired diastolic ventricular function resulting in a poor clinical prognosis. Rarely, heritable forms of RCM have been reported, and mutations underly…

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH Open

Atze van der Pol, Andrés Gil, Herman H.W. Silljé, Jasper Tromp, Ekaterina S. Ovchinnikova , et al. · 2017

OPLAH is cardioprotective for myocardial infarction, and its substrate 5-oxoproline is a putative circulating marker for heart failure.

Single‐Cell Functional Analysis of Stem‐Cell Derived Cardiomyocytes on Micropatterned Flexible Substrates Open

Jan David Kijlstra, Dongjian Hu, Peter van der Meer, Ibrahim J. Domian · 2017

Human pluripotent stem–cell derived cardiomyocytes (hPSC‐CMs) hold great promise for applications in human disease modeling, drug discovery, cardiotoxicity screening, and, ultimately, regenerative medicine. The ability to study multiple pa…

Sub-Confluent Culture of Mouse Embryonic Stem Cell-derived Ventricular Cardiomyocytes On & In Gels - Enhancement of Maturation Phenotype Relative to Tissue Culture Polystyrene via Enabling of Auxotonic Contraction Open

Nikhil Mittal, Ayhan Atmanli, Dongjian Hu, Daniel Groeneweg, Eduardo Kausel , et al. · 2017

Cardiac myocytes (CMs) obtained by differentiating embryonic stem cells (ES-CMs) have an immature phenotype and promoting the maturation of such PSC-derived cardiomyocytes remains a major limitation in the development of stem cell models o…

Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells Open

Cláudia Correia, Alexey Koshkin, Patrícia Duarte, Dongjian Hu, Ana P. Teixeira , et al. · 2017

Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease Open

Ayhan Atmanli, Ibrahim J. Domian · 2016

CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells Open

Ivette Pacheco-Leyva, Ana Catarina Matias, Daniel V. Oliveira, João Miguel Almeida Santos, Rita Nascimento , et al. · 2016

Distilling complexity to advance cardiac tissue engineering Open

Brenda M. Ogle, Nenad Bursac, Ibrahim J. Domian, Ngan F. Huang, Philippe Menasché , et al. · 2016

Five central challenges must be met to advance the current state of the art in modeling heart disease and realizing heart repair.

Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production Open

Connie Wu, Pankaj Arora, Obiajulu Agha, Liam A. Hurst, Kaitlin Allen , et al. · 2016

Atrial natriuretic peptide (ANP) has a central role in regulating blood pressure in humans. Recently, microRNA 425 (miR-425) was found to regulate ANP production by binding to the mRNA of NPPA, the gene encoding ANP. mRNAs typically contai…

Acute Metabolic Influences on the Natriuretic Peptide System in Humans Open

Pankaj Arora, Connie Wu, Tariq Hamid, Garima Arora, Obiajulu Agha , et al. · 2016

Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation Open

Derek Passer, Annebel van de Vrugt, Ayhan Atmanli, Ibrahim J. Domian · 2016

A hallmark of cardiac development is the formation of myocardial trabeculations exclusively from the luminal surface of the primitive heart tube. Although a number of genetic defects in the endocardium and cardiac jelly disrupt myocardial …

An integrated statistical model for enhanced murine cardiomyocyte differentiation via optimized engagement of 3D extracellular matrices Open

Jangwook P. Jung, Dongjian Hu, Ibrahim J. Domian, Brenda M. Ogle · 2015

Integrated Analysis of Contractile Kinetics, Force Generation, and Electrical Activity in Single Human Stem Cell-Derived Cardiomyocytes Open

Jan David Kijlstra, Dongjian Hu, Nikhil Mittal, Eduardo Kausel, Peter van der Meer , et al. · 2015

Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss Open

Anthony C. Sturzu, Kuppusamy Rajarajan, Derek Passer, Karolina Plonowska, Alyssa K. Riley , et al. · 2015

Background— Heart development is tightly regulated by signaling events acting on a defined number of progenitor and differentiated cardiac cells. Although loss of function of these signaling pathways leads to congenital malformation, the c…

Anisotropic silk biomaterials containing cardiac extracellular matrix for cardiac tissue engineering Open

Whitney L. Stoppel, Dongjian Hu, Ibrahim J. Domian, David L. Kaplan, Lauren D. Black · 2015

Cardiac malformations and disease are the leading causes of death in the United States in live-born infants and adults, respectively. In both of these cases, a decrease in the number of functional cardiomyocytes often results in improper g…

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