John C. Nash
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View article: 15 JAK/STAT PATHWAY CO-OPERATES WITH CIC-FUSIONS TO DRIVE CIC-REARRANGED SARCOMAS
15 JAK/STAT PATHWAY CO-OPERATES WITH CIC-FUSIONS TO DRIVE CIC-REARRANGED SARCOMAS Open
CIC-rearranged sarcoma (CRS) is a rare and aggressive malignancy driven by CIC fusion proteins, primarily CIC-DUX4, with a propensity for brain metastases. Other fusion partners, such as CIC-NUTM1, have been identified in a subset of pedia…
View article: Various approaches to solving nonlinear equations
Various approaches to solving nonlinear equations Open
Modelling real world systems frequently requires the solution of systems of nonlinear equations. A number of approaches have been suggested and developed for this computational problem. However, it is also possible to attempt solutions usi…
View article: Optimization problems constrained by parameter sums
Optimization problems constrained by parameter sums Open
This article presents a discussion of optimization problems where the objective function f(x) has parameters that are constrained by some scaling, so that q(x) = constant, where this function q() involves a sum of the parameters, their squ…
View article: A Comparison of R Tools for Nonlinear Least Squares Modeling
A Comparison of R Tools for Nonlinear Least Squares Modeling Open
Our Google Summer of Code project "Improvements to `nls()`" investigated rationalizing R tools for nonlinear regression and nonlinear estimation tools by considering usability, maintainability, and functionality, especially for a Gauss-New…
View article: A 2019-2020 Review of R Neural Network Packages with NNbenchmark
A 2019-2020 Review of R Neural Network Packages with NNbenchmark Open
In the last three decades, neural networks have evolved from an academic topic to a common scientific computing tool. CRAN currently hosts around 80 packages (May 2020) that involve neural network modeling; some offering more than one algo…
View article: Mid-Rotation Impacts of Stand Tending with Glyphosate on Plant Diversity in the Boreal Forest of West-Central Alberta
Mid-Rotation Impacts of Stand Tending with Glyphosate on Plant Diversity in the Boreal Forest of West-Central Alberta Open
Stand tending using glyphosate to promote coniferous overstory trees has been a common practice in the boreal forests of Alberta. However, there are concerns about the impact of this practice on biodiversity of understory species. This stu…
View article: Software and procedural tools for productivity enhancement in specialized data entry applications
Software and procedural tools for productivity enhancement in specialized data entry applications Open
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View article: Provenance of R’s Gradient Optimizers
Provenance of R’s Gradient Optimizers Open
View article: Navigating the R Package Universe
Navigating the R Package Universe Open
Today, the enormous number of contributed packages available to R users outstrips any given user's ability to understand how these packages work, their relative merits, or how they are related to each other.We organized a plenary session a…
View article: Evaluating Transport Infrastructure Projects in Low Data Environments: An Application to Nigeria
Evaluating Transport Infrastructure Projects in Low Data Environments: An Application to Nigeria Open