John K. Kuster
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View article: JS07.6.A AGE-APPROPRIATE MODELS OF PAEDIATRIC BRAIN TUMOURS REVEAL THE INFLUENCE OF AGE ON TUMOUR-IMMUNE INTERACTION.
JS07.6.A AGE-APPROPRIATE MODELS OF PAEDIATRIC BRAIN TUMOURS REVEAL THE INFLUENCE OF AGE ON TUMOUR-IMMUNE INTERACTION. Open
BACKGROUND The developing immune system of a child is distinct to that of an adult. These differences in the immune system are often ignored in preclinical paediatric cancer research, where adult mice are more commonly used, overlooking po…
View article: Enhancer Hijacking of the IGH Locus as a Novel Genetic Mechanism of an Inborn Error of Immunity Leading to Invasive <i>Streptococcus pneumoniae</i> Infection due to Antibody Deficiency
Enhancer Hijacking of the IGH Locus as a Novel Genetic Mechanism of an Inborn Error of Immunity Leading to Invasive <i>Streptococcus pneumoniae</i> Infection due to Antibody Deficiency Open
We investigated the genetic cause of disease in five affected individuals from two unrelated families with an autosomal dominant pattern of invasive Streptococcus pneumoniae infection associated with a clinical phenotype of specific antibo…
View article: A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome
A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome Open
Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after severe acute respiratory syndrom…
View article: A genetically modulated Toll-like-receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome
A genetically modulated Toll-like-receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome Open
Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after SARS-CoV-2 exposure. To investig…
View article: Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling
Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling Open
This cohort study evaluated the diagnostic accuracy of PEN-FAST as a clinical decision-making tool to enhance penicillin allergy evaluation.
View article: Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia
Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia Open
We previously observed sustained fMRI BOLD signal in the basal ganglia in focal hand dystonia patients after a repetitive finger tapping task. Since this was observed in a task-specific dystonia, for which excessive task repetition may pla…
View article: MIF is a common genetic determinant of COVID-19 symptomatic infection and severity
MIF is a common genetic determinant of COVID-19 symptomatic infection and severity Open
Background Genetic predisposition to coronavirus disease 2019 (COVID-19) may contribute to its morbidity and mortality. Because cytokines play an important role in multiple phases of infection, we examined whether commonly occurring, funct…
View article: A review of the safety of oral immunotherapy in clinical trial and real-world studies
A review of the safety of oral immunotherapy in clinical trial and real-world studies Open
Safety concerns are a barrier to oral immunotherapy (OIT). This review aims to describe OIT safety events and explore potential risk factors and mitigating factors. Published clinical and real-world OIT studies were reviewed for data on sa…
View article: The Commonality of Loss Aversion across Procedures and Stimuli
The Commonality of Loss Aversion across Procedures and Stimuli Open
Individuals tend to give losses approximately 2-fold the weight that they give gains. Such approximations of loss aversion (LA) are almost always measured in the stimulus domain of money, rather than objects or pictures. Recent work on pre…
View article: White Matter Changes in Cervical Dystonia Relate to Clinical Effectiveness of Botulinum Toxin Treatment
White Matter Changes in Cervical Dystonia Relate to Clinical Effectiveness of Botulinum Toxin Treatment Open
In a previous report showing white matter microstructural hemispheric asymmetries medial to the pallidum in focal dystonias, we showed preliminary evidence that this abnormality was reduced 4 weeks after botulinum toxin (BTX) injections. I…
View article: A registration method for improving quantitative assessment in probabilistic diffusion tractography
A registration method for improving quantitative assessment in probabilistic diffusion tractography Open
Diffusion MRI-based probabilistic tractography is a powerful tool for non-invasively investigating normal brain architecture and alterations in structural connectivity associated with disease states. Both voxelwise and region-of-interest m…
View article: Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias
Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias Open
Reduced thalamic gross volume, detected in two independent analyses, suggests a common anatomical abnormality in cervical dystonia and spasmodic dysphonia. Defining the structural underpinnings of dystonia may require such complementary ap…
View article: Variable activation in striatal subregions across components of a social influence task in young adult cannabis users
Variable activation in striatal subregions across components of a social influence task in young adult cannabis users Open
Introduction Decades of research have demonstrated the importance of social influence in initiation and maintenance of drug use, but little is known about neural mechanisms underlying social influence in young adults who use recreational d…
View article: Experimental Procedures and Resulting Value Functions.
Experimental Procedures and Resulting Value Functions. Open
(a) The PT-based experiment used two “gambles”, schematized by two spinners. One spinner showed two-thirds of its area as gains (+$10) and one-third as losses (-$8), leading to an expected outcome (i.e., referred to as actuarial outcome in…
View article: Definition of Loss Aversion (LA) and Correlation Between Measures.
Definition of Loss Aversion (LA) and Correlation Between Measures. Open
(a) The local definition of LA focuses on the slopes of the value function on the either side of an inflection point between approach and avoidance (s+ and s- respectively), or gains and losses. Measures of s+ and s- are collected close to…
View article: The Commonality of Loss Aversion across Procedures and Stimuli
The Commonality of Loss Aversion across Procedures and Stimuli Open
Individuals tend to give losses approximately 2-fold the weight that they give gains. Such approximations of loss aversion (LA) are almost always measured in the stimulus domain of money, rather than objects or pictures. Recent work on pre…