Explanipedia

Placebo rates in randomized clinical trials of ulcerative colitis: an individual patient data meta-analysis Open

Virginia Solitano, Malcolm Hogan, Siddharth Singh, Silvio Danese, Laurent Peyrin-Biroulet , et al. · 2025

Background and Aims We assessed placebo rates and associated factors using individual patient data (IDP) from randomized clinical trials (RCTs) in ulcerative colitis (UC). Methods We conducted an IPD meta-analysis using Vivli and Yale Univ…

Medical Therapy for Acute Severe Ulcerative Colitis: A Systematic Review With Meta-analysis Open

Sudheer K. Vuyyuru, Nader Shaban, Yuhong Yuan, Sailish Honap, Lotus Alphonsus , et al. · 2025

IFX may be more efficacious than cyclosporine A for the treatment of ASUC. Janus kinase inhibitors are promising treatment options in select individuals. Future studies should explore the efficacy of other advanced therapies.

Endoscopic scoring indices for assessing disease severity in familial adenomatous polyposis: Systematic review Open

Anna L. Silverman, Hicham Bouchiba, Arthur S. Aelvoet, John K MacDonald, Evelien Dekker , et al. · 2024

Background and study aims There is limited consensus on the optimal method for measuring disease severity in familial adenomatous polyposis (FAP). We aimed to systematically review the operating properties of existing endoscopic severity i…

Use of external control arms in immune-mediated inflammatory diseases: a systematic review Open

Alexa Zayadi, Robert Edge, Claire E. Parker, John K MacDonald, Blue Neustifter , et al. · 2023

Objectives External control arms (ECAs) provide useful comparisons in clinical trials when randomised control arms are limited or not feasible. We conducted a systematic review to summarise applications of ECAs in trials of immune-mediated…

Systematic review with meta‐analysis: Medical therapies for treatment of ulcerative proctitis Open

Achuthan Aruljothy, Siddharth Singh, Neeraj Narula, Gordon W. Moran, Sudheer K. Vuyyuru , et al. · 2023

Summary Background Ulcerative proctitis (UP) is a common highly symptomatic form of ulcerative colitis that can be difficult to treat. Aim To assess the efficacy of medical treatments for UP. Methods We searched MEDLINE, EMBASE, and CENTRA…

Efficacy and Safety of IL-12/23 and IL-23 Inhibitors for Crohn’s Disease: Systematic Review and Meta-Analysis Open

Sudheer K. Vuyyuru, Virginia Solitano, Malcolm Hogan, John K MacDonald, Alexa Zayadi , et al. · 2023

Recommendations for standardizing biopsy acquisition and histological assessment of immune checkpoint inhibitor-associated colitis Open

Christopher Ma, Rish K. Pai, David F. Schaeffer, Jonathan Krell, Leonardo Guizzetti , et al. · 2022

Immune checkpoint inhibitor-associated colitis (ICIC) affects approximately 15% of cancer patients treated with immunotherapy. Although histological evaluation is potentially valuable for both the diagnosis of ICIC and evaluation of diseas…

The Relationship Between Endoscopic and Clinical Recurrence in Postoperative Crohn’s Disease: A Systematic Review and Meta-analysis Open

Alessandro Blè, Cecilia Renzulli, Fabio Cenci, Maria Grimaldi, Michelangelo Barone , et al. · 2021

Background and Aims We aimed to quantify the magnitude of the association between endoscopic recurrence and clinical recurrence [symptom relapse] in patients with postoperative Crohn’s disease. Methods Databases were searched to October 2,…

Medical Management Following Surgical Therapy in Inflammatory Bowel Disease: Evidence from Cochrane Reviews Open

Nilesh Chande, Siddharth Singh, Neeraj Narula, Morris Gordon, M Ellen Kuenzig , et al. · 2021

The Cochrane Inflammatory Bowel Diseases Group presented a symposium at Digestive Diseases Week 2019 entitled “Medical Management Following Surgical Therapy in Inflammatory Bowel Disease: Evidence from Cochrane Reviews”. This article summa…

Pancreatitis associated with azathioprine and 6-mercaptopurine use in Crohn’s disease: a systematic review Open

Morris Gordon, Ciaran Grafton‐Clarke, Anthony K Akobeng, John K MacDonald, Nilesh Chande , et al. · 2020

Thiopurines are proven agents in the treatment of Crohn’s disease. While pancreatitis is recognised as an adverse event associated with therapy, the effect size and morbidity of thiopurine-induced pancreatitis is not known. The aim of this…

Adalimumab for maintenance of remission in Crohn's disease Open

Cassandra Townsend, Tran M Nguyen, Jeremy Cepek, Mohamad Abbass, Claire E. Parker , et al. · 2020

Adalimumab is an effective therapy for maintenance of clinical remission in people with quiescent CD. Adalimumab is also effective in those who have previously been treated with TNF-α antagonists. The effect of adalimumab in the post-surgi…

Anti-IL-12/23p40 antibodies for maintenance of remission in Crohn's disease Open

Sarah Davies, Tran M Nguyen, Claire E. Parker, John K MacDonald, Vipul Jairath , et al. · 2019

Moderate-certainty evidence suggests that ustekinumab is probably effective for the maintenance of clinical remission and response in people with moderate to severe CD in remission without an increased risk of adverse events (high-certaint…

Alternative and Complementary Approaches for the Treatment of Inflammatory Bowel Disease: Evidence From Cochrane Reviews Open

Nilesh Chande, Samuel P. Costello, Berkeley N. Limketkai, Claire E. Parker, Tran M Nguyen , et al. · 2019

The Cochrane IBD Group presented a symposium at Digestive Diseases Week 2018 entitled “Alternative and Complementary Approaches for the Treatment of IBD: Evidence from Cochrane Reviews.” This article summarizes the data presented at this s…

Interventions for maintenance of surgically induced remission in Crohn’s disease: a network meta-analysis Open

Zipporah Iheozor‐Ejiofor, Morris Gordon, Andrew Clegg, Suzanne C Freeman, Teuta Gjuladin-Hellon , et al. · 2019

Due to low-certainty evidence in the networks, we are unable to draw conclusions on which treatment is most effective for preventing clinical relapse and endoscopic relapse. Evidence on the safety of the interventions was inconclusive, how…

Optimal Approach to Lobectomy for Non-Small Cell Lung Cancer: Systemic Review and Meta-Analysis Open

Calvin S.H. Ng, John K MacDonald, Sebastién Gilbert, Ali Zamir Khan, Young Tae Kim , et al. · 2019

Objective Video-assisted thoracic surgery (VATS) lobectomy was introduced over 25 years ago. More recently, the technique has been modified from a multiport video-assisted thoracic surgery (mVATS) to uniportal (uVATS) and robotic (rVATS), …

Expert Consensus Statement on Optimal Approach to Lobectomy for Non-Small Cell Lung Cancer Open

Calvin S.H. Ng, John K MacDonald, Sebastién Gilbert, Ali Zamir Khan, Young Tae Kim , et al. · 2019

Dietary interventions for induction and maintenance of remission in inflammatory bowel disease Open

Berkeley N. Limketkai, Zipporah Iheozor‐Ejiofor, Teuta Gjuladin-Hellon, Alyssa M. Parian, Laura E. Matarese , et al. · 2019

The effects of dietary interventions on CD and UC are uncertain. Thus no firm conclusions regarding the benefits and harms of dietary interventions in CD and UC can be drawn. There is need for consensus on the composition of dietary interv…

Antibiotics for induction and maintenance of remission in Crohn's disease Open

Cassandra Townsend, Claire E. Parker, John K MacDonald, Tran M Nguyen, Vipul Jairath , et al. · 2019

Background Several antibiotics have been evaluated in Crohn's disease (CD), however randomised controlled trials (RCTs) have produced conflicting results. Objectives To assess the efficacy and safety of antibiotics for induction and mainte…

Interventions for maintenance of surgically-induced remission in Crohn’s disease: a network meta-analysis Open

Andrew Clegg, Zipporah Iheozor‐Ejiofor, Morris Gordon, John K MacDonald, Anthony K Akobeng · 2018

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects and harms of interventions for the maintenance of surgically‐induced remission in Crohn's disease and to rank treatments in order…

Correction: Reflections on recovery, rehabilitation and reintegration of injured service members and veterans from a bio-psychosocial-spiritual perspective Open

John K MacDonald · 2018

was clearly able to fashion persuasive arguments speci c to the hospital, the clinician, the university and the Rockefeller Foundation as required.Currie undertook all these challenges while he faced slander regarding his leadership in the…

Cannabis for the treatment of Crohn's disease Open

Tahir S Kafil, Tran M Nguyen, John K MacDonald, Nilesh Chande · 2018

Background Crohn's disease (CD) is a chronic immune‐mediated condition of transmural inflammation in the gastrointestinal tract, associated with significant morbidity and decreased quality of life. The endocannabinoid system provides a pot…

Cannabis for the treatment of ulcerative colitis Open

Tahir S Kafil, Tran M Nguyen, John K MacDonald, Nilesh Chande · 2018

The effects of cannabis and cannabidiol on UC are uncertain, thus no firm conclusions regarding the efficacy and safety of cannabis or cannabidiol in adults with active UC can be drawn.There is no evidence for cannabis or cannabinoid use f…

Enteral nutrition for maintenance of remission in Crohn's disease Open

Anthony K Akobeng, Dongni Zhang, Morris Gordon, John K MacDonald · 2018

Background Prevention of relapse is a major issue in the management of quiescent Crohn's disease (CD). Current therapies (e.g. methotrexate, biologics, 6‐mercaptopurine and azathioprine) may be effective for maintaining remission in CD, bu…

Natalizumab for induction of remission in Crohn's disease Open

Seana M.L. Nelson, Tran M Nguyen, John WD McDonald, John K MacDonald · 2018

This systematic review update summarizes the current evidence on the use of natalizumab for induction of remission in Crohn's disease (CD).To determine the efficacy and safety of natalizumab for induction of remission in CD.We searched MED…

Low dose naltrexone for induction of remission in Crohn's disease Open

Claire E. Parker, Tran M Nguyen, Dan Segal, John K MacDonald, Nilesh Chande · 2018

Crohn's disease is a transmural, relapsing inflammatory condition afflicting the digestive tract. Opioid signalling, long known to affect secretion and motility in the gut, has been implicated in the inflammatory cascade of Crohn's disease…

Endoscopic scoring indices for evaluation of disease activity in ulcerative colitis Open

Nadia Mohammed Vashist, Mark Samaan, Mahmoud Mosli, Claire E. Parker, John K MacDonald , et al. · 2018

While the UCEIS, UCCIS and Mayo Clinic Endoscopic Subscore have undergone extensive validation, none of these instruments have been fully validated and only two studies assessed responsiveness. Further research on the operating properties …

Adalimumab for induction of remission in Crohn's disease Open

Mohamad Abbass, Jeremy Cepek, Claire E. Parker, Tran M Nguyen, John K MacDonald , et al. · 2017

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The primary objective of this review is to assess the efficacy and safety of adalimumab for induction of remission in patients with active CD.

Adalimumab for maintenance of remission in Crohn's disease Open

Jeremy Cepek, Mohamad Abbass, Tran M Nguyen, Claire E. Parker, John K MacDonald , et al. · 2017

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objective of this review is to assess the efficacy and safety of adalimumab for maintenance of remission in patients with quiescent CD.

Interventions for treating collagenous colitis Open

Tahir S Kafil, Tran Minh Nhu Nguyen, Petrease H Patton, John K MacDonald, Nilesh Chande , et al. · 2017

Low quality evidence suggests that budesonide may be effective for inducing and maintaining clinical and histological response in patients with collagenous colitis. We are uncertain about the benefits and harms of therapy with bismuth subs…

Cannabis for the treatment of Crohn's disease Open

Tahir S Kafil, Tran M Nguyen, John K MacDonald, Nilesh Chande · 2017

The effects of cannabis and cannabis oil on Crohn's disease are uncertain. Thus no firm conclusions regarding the efficacy and safety of cannabis and cannabis oil in adults with active Crohn's disease can be drawn. The effects of cannabis …

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