John Ketz
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View article: Reduction of Posterior Malleolus Fractures With Open Fixation Compared to Percutaneous Treatment
Reduction of Posterior Malleolus Fractures With Open Fixation Compared to Percutaneous Treatment Open
Background: Operative decision making between approaches to posterior malleolus reduction remains a challenge. The purpose of this study is to compare the quality of reduction between percutaneous and open reduction of posterior malleolus …
View article: Clinical Improvement Following Operative Management of Ankle Fractures Among Patients With and Without Moderate to High Depressive Symptoms: An Analysis Using PROMIS
Clinical Improvement Following Operative Management of Ankle Fractures Among Patients With and Without Moderate to High Depressive Symptoms: An Analysis Using PROMIS Open
Background: Understanding the recovery trajectory following operative management of ankle fractures can help surgeons guide patient expectations. Further, it is beneficial to consider the impact of mental health on the recovery trajectory.…
View article: Impingement in Insertional Achilles Tendinopathy Occurs Across a Larger Range of Ankle Angles and Is Associated With Increased Tendon Thickness
Impingement in Insertional Achilles Tendinopathy Occurs Across a Larger Range of Ankle Angles and Is Associated With Increased Tendon Thickness Open
Background: Insertional Achilles tendinopathy (IAT) is characterized by tendon degeneration and thickening near the tendon-bone insertion. 11 Calcaneal impingement is believed to contribute to the pathogenesis of IAT. 5 However, it is uncl…
View article: Reduction Quality of Open vs Percutaneous Techniques for the Posterior Malleolus
Reduction Quality of Open vs Percutaneous Techniques for the Posterior Malleolus Open
Category: Ankle; Trauma Introduction/Purpose: Ankle fractures with posterior malleolar involvement are common. Fixation of the posterior malleolus (PM) in these injuries remains controversial & currently, there is no evidence to guide oper…
View article: IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice
IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice Open
NF-κB signaling in articular chondrocytes increases with age and promotes the onset of age-related osteoarthritis in mice.
View article: Survey of the Use of Physician Review Websites in Patients Under Orthopaedic Care (Preprint)
Survey of the Use of Physician Review Websites in Patients Under Orthopaedic Care (Preprint) Open
BACKGROUND Physician-rating websites (PRWs) are rising in popularity as the healthcare sector focuses more on patient-centered value-based care delivery. Recent studies have reported that the vast majority of orthopaedic surgeons across s…
View article: Deleted in malignant brain tumor <i>1</i> genetic variation confers urinary tract infection risk in children and mice
Deleted in malignant brain tumor <i>1</i> genetic variation confers urinary tract infection risk in children and mice Open
We identify that children with a history of urinary tract infections (UTIs) and vesicoureteral reflux (VUR) with low deleted in Malignant Brain Tumors 1 (DMBT1) DNA copy number have ∼4-fold higher odds of recurrent UTIs compared to those w…
View article: Results of Staged Treatment with External Fixation for High Energy Calcaneus Fractures
Results of Staged Treatment with External Fixation for High Energy Calcaneus Fractures Open
Category: Trauma; Hindfoot Introduction/Purpose: High energy calcaneus fractures have significant soft tissue compromise and typically poor outcomes. The purpose of this study was to describe patient complications and outcomes, after under…
View article: Long-Term Patient Reported Outcomes after Correction of Traumatic Foot Drop
Long-Term Patient Reported Outcomes after Correction of Traumatic Foot Drop Open
Category: Trauma; Ankle Introduction/Purpose: There is limited literature on patient reported outcomes after tendon transfer for traumatic foot drop. The purpose of this study was to determine long-term patient reported functional outcomes…
View article: Is there a Difference in Outcomes between Patients who Received a Double or Triple Arthrodesis for Hindfoot Arthritis?
Is there a Difference in Outcomes between Patients who Received a Double or Triple Arthrodesis for Hindfoot Arthritis? Open
Category: Hindfoot Introduction/Purpose: Triple arthrodesis has historically been considered the standard of treatment for arthritis of the hindfoot with or without deformity. The complications of this surgery including non-union, malunion…
View article: Rethinking strategies for blood transfusion in hip fracture patients
Rethinking strategies for blood transfusion in hip fracture patients Open
Objectives: Most patients can tolerate a hemoglobin (Hgb) > 8 g per deciliter. In some cases, however, transfusion will delay physical therapy and hospital discharge. This study aims to review Hgb and transfusion data for a large volume of…
View article: Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections Open
Biomarkers panel can be identified by the emerging technologies of aptamer-based proteomics and machine learning that offer the potential to increase UTI diagnostic accuracy, thereby limiting unneeded antibiotics.
View article: Pattern of recovery and outcomes of patient reported physical function and pain interference after ankle fusion: a retrospective cohort study
Pattern of recovery and outcomes of patient reported physical function and pain interference after ankle fusion: a retrospective cohort study Open
Background Research on outcomes after ankle fusion focuses on basic activities of daily living, fusion rates, and gait parameters. Little has been reported on the patient’s perspective after surgery. The purpose of this study was to determ…
View article: Developmental loss, but not pharmacological suppression, of renal carbonic anhydrase 2 results in pyelonephritis susceptibility
Developmental loss, but not pharmacological suppression, of renal carbonic anhydrase 2 results in pyelonephritis susceptibility Open
Carbonic anhydrase II knockout ( Car2 −/− ) mice have depleted numbers of renal intercalated cells, which are increasingly recognized to be innate immune effectors. We compared pyelonephritis susceptibility following reciprocal renal trans…
View article: Radiographic Outcomes after Flexible Flatfoot Reconstruction with and without Spring Ligament Reconstruction
Radiographic Outcomes after Flexible Flatfoot Reconstruction with and without Spring Ligament Reconstruction Open
Category: Hindfoot Introduction/Purpose: The purpose of this study was to determine postoperative radiographic differences between patients who underwent flexible flatfoot reconstruction and spring ligament repair with a FiberTape suture d…
View article: Are Sicker Patients Less Likely to Improve after Ankle Fusion?
Are Sicker Patients Less Likely to Improve after Ankle Fusion? Open
Category: Ankle Arthritis Introduction/Purpose: The influence of pre-existing medical conditions on post-operative patient reported outcomes are important to consider when selecting and preparing a patient for surgery. The purpose of this …
View article: Matching Patient Expectations after Ankle Fusion Based on Patient Reported Outcome Measures
Matching Patient Expectations after Ankle Fusion Based on Patient Reported Outcome Measures Open
Category: Ankle Arthritis Introduction/Purpose: Much research on outcomes after ankle fusion focuses on gait changes, progression of adjacent joint arthritis, and other clinical measures, but little has been reported on the patient’s persp…
View article: Should Chopart Amputation be Performed in Diabetic Foot Ulcer Patients?
Should Chopart Amputation be Performed in Diabetic Foot Ulcer Patients? Open
Category: Diabetes, Midfoot/Forefoot Introduction/Purpose: Diabetic foot ulcers (DFU) with deep infections and osteomyelitis often lead to partial or complete limb loss. Determination of the appropriate level for amputation is challenging,…
View article: Immediate Improvement in Physical Function after Symptomatic Syndesmotic Screw Removal
Immediate Improvement in Physical Function after Symptomatic Syndesmotic Screw Removal Open
Category: Ankle, Trauma Introduction/Purpose: The purpose of this study was to investigate the immediate impact of removing symptomatic syndesmotic screws on PROMIS outcomes and ankle range of motion (ROM) in patients who had previously un…
View article: Mortality Rates of Humerus Fractures in the Elderly: Does Surgical Treatment Matter?
Mortality Rates of Humerus Fractures in the Elderly: Does Surgical Treatment Matter? Open
Introduction: Multiple studies have shown the impact of hip fractures on geriatric mortality. Few evaluate mortality after proximal humerus (PH) or distal humerus (DH) fractures, and fewer determine differences in mortality based on manage…
View article: Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice
Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice Open
RUNX2 is a transcription factor critical for chondrocyte maturation and normal endochondral bone formation. It promotes the expression of factors catabolic to the cartilage extracellular matrix and is upregulated in human osteoarthritic ca…
View article: Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha Function
Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha Function Open
The renal collecting duct consists of intercalated cells (ICs) and principal cells (PCs). We have previously demonstrated that collecting ducts have a role in the innate immune defense of the kidney. Transcriptomics is an important tool us…
View article: Ankle fractures: What role does level of insurance play in recovery and outcomes?
Ankle fractures: What role does level of insurance play in recovery and outcomes? Open
Introduction A number of factors including socioeconomic status have been correlated with post-operative outcomes in orthopedic trauma. The objective of this study is to compare post-operative courses and patient-reported outcomes followin…
View article: Chondrocyte-specific RUNX2 Overexpression Causes Chondrodysplasia During Development, but is Not Sufficient to Induce OA-like Articular Cartilage Degeneration in Adult Mice Without Injury
Chondrocyte-specific RUNX2 Overexpression Causes Chondrodysplasia During Development, but is Not Sufficient to Induce OA-like Articular Cartilage Degeneration in Adult Mice Without Injury Open
RUNX2 is a transcription factor critical for chondrocyte maturation and normal endochondral bone formation. It promotes the expression of factors catabolic to the cartilage extracellular matrix and is shown to be upregulated in human osteo…
View article: Pain Assessment in Foot and Ankle Patients
Pain Assessment in Foot and Ankle Patients Open
Category: Other Introduction/Purpose: The ability to accurately quantify a patient’s pain pre-operatively is advantageous in the preparation of post-operative expectations and pain management. The Numeric Pain Rating Scale (NPRS) is a popu…