John Kingdom
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View article: Developmental trajectories predictive of stillbirth in a longitudinal mouse model of fetal growth restriction
Developmental trajectories predictive of stillbirth in a longitudinal mouse model of fetal growth restriction Open
Fetal growth restriction, often caused by placental disease, is an important cause of fetal injury and stillbirth. Understanding how the fetus adapts under these conditions is key to predicting survival. Here we report physiological adapta…
View article: Falling Third Trimester Insulin Requirements and Adverse Pregnancy Outcomes in Individuals with Pre-Existing Diabetes: A Retrospective Cohort Study
Falling Third Trimester Insulin Requirements and Adverse Pregnancy Outcomes in Individuals with Pre-Existing Diabetes: A Retrospective Cohort Study Open
Objective: To determine whether a third-trimester drop in insulin requirements in pregnant people with pre-existing diabetes is associated with a subsequent occurrence of adverse pregnancy outcomes. Research Design and Methods: We conducte…
View article: Factors affecting the umbilical artery Doppler reference values in the second and third trimesters
Factors affecting the umbilical artery Doppler reference values in the second and third trimesters Open
Objective To explore the contribution of selected methodological factors to the heterogeneity in published umbilical artery pulsatility index (UA‐PI) reference charts. Methods Cross‐sectional study of uncomplicated singleton pregnancies th…
View article: Guidelines on Placenta Accreta Spectrum Disorders
Guidelines on Placenta Accreta Spectrum Disorders Open
Importance Placenta accreta spectrum (PAS) is a complex, life-threatening condition that demands a multidisciplinary approach involving obstetrics, maternal-fetal medicine, and various surgical and medical specialties. Effective management…
View article: Neurodevelopment Among Infants With Late-Onset Fetal Growth Restriction
Neurodevelopment Among Infants With Late-Onset Fetal Growth Restriction Open
Importance Fetal growth restriction (FGR) is associated with adverse neurodevelopmental outcomes. However, the delineation of neurodevelopmental sequela in late-onset FGR has been hampered by challenges in diagnosing late-onset FGR and the…
View article: Propranolol and Oxytocin‐Induced Contractility in Gravid Human Myometrium: An Ex Vivo Laboratory Study
Propranolol and Oxytocin‐Induced Contractility in Gravid Human Myometrium: An Ex Vivo Laboratory Study Open
Objective To determine the effect of propranolol on myometrial contractions induced by low dose and high dose oxytocin. Design Prospective ex vivo laboratory study. Setting Mount Sinai Hospital, Toronto. Population Full‐term parturients wh…
View article: Where is communication breaking down? Narrative tensions in obesity-in-pregnancy clinical encounters
Where is communication breaking down? Narrative tensions in obesity-in-pregnancy clinical encounters Open
There are numerous biomedical and psychosocial challenges associated with obesity in pregnancy that impede communication between healthcare providers (HCPs) and patients. We conducted a narrative study informed by stigma theory to understa…
View article: Altered adult brain morphology in a mouse model of late-onset fetal growth restriction
Altered adult brain morphology in a mouse model of late-onset fetal growth restriction Open
Late-onset fetal growth restriction (FGR) from placental insufficiency results in progressive fetal hypoxia and is often associated with poor neurodevelopmental outcomes. In response to hypoxia, fetal brain sparing physiology is activated …
View article: Association of Acute Histological Chorioamnionitis and Other Placental Lesions With Subsequent Pregnancy Outcomes After Spontaneous Preterm Birth
Association of Acute Histological Chorioamnionitis and Other Placental Lesions With Subsequent Pregnancy Outcomes After Spontaneous Preterm Birth Open
PTB with HCA is associated with higher rates of extreme PTB and adverse neonatal outcomes in the subsequent pregnancy. The inclusion of placental pathology analysis may improve individualized risk assessment in future pregnancies.
View article: Midpregnancy Placental Growth Factor Screening and Early Preterm Birth
Midpregnancy Placental Growth Factor Screening and Early Preterm Birth Open
Importance Early preterm birth (ie, at less than 34 weeks’ gestation) confers a high risk for adverse health outcomes, yet no universal screening strategy exists, preventing targeted delivery of effective interventions. Objective To evalua…
View article: Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysis
Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysis Open
Objective To predict birth weight at various potential gestational ages of delivery based on data routinely available at the first antenatal visit. Design Individual participant data meta-analysis. Data sources Individual participant data …
View article: Phenotypes of maternal vascular malperfusion placental pathology and adverse pregnancy outcomes: A retrospective cohort study
Phenotypes of maternal vascular malperfusion placental pathology and adverse pregnancy outcomes: A retrospective cohort study Open
Objective To identify which components of maternal vascular malperfusion (MVM) pathology are associated with adverse pregnancy outcomes and to investigate the morphological phenotypes of MVM placental pathology and their relationship with …
View article: Fetal Hemodynamics, Early Survival, and Neurodevelopment in Patients With Cyanotic Congenital Heart Disease
Fetal Hemodynamics, Early Survival, and Neurodevelopment in Patients With Cyanotic Congenital Heart Disease Open
Among fetuses with cyanotic CHD, diminished fetal combined ventricular output is associated with mortality, whereas cerebral blood flow and oxygen delivery are associated with early cognitive, language, and motor development at 18 months o…
View article: The Future of Forceps Delivery in Canada
The Future of Forceps Delivery in Canada Open
The history of the emergence of forceps as an effective delivery intervention was cloaked in secrecy for over 100 years by the Chamberlen family, until 5 pairs of the instruments were discovered under the floorboards of Woodham Mortimer Ha…
View article: Maternal exposure to polyethylene micro- and nanoplastics impairs umbilical blood flow but not fetal growth in pregnant mice
Maternal exposure to polyethylene micro- and nanoplastics impairs umbilical blood flow but not fetal growth in pregnant mice Open
While microplastics have been recently detected in human blood and the placenta, their impact on human health is not well understood. Using a mouse model of environmental exposure during pregnancy, our group has previously reported that ex…
View article: Cord entrapment in a footling breech presentation with decreased fetal movements
Cord entrapment in a footling breech presentation with decreased fetal movements Open
KEY POINTS A 28-year-old woman presented to the obstetric triage unit at 35 + 5 weeks' gestation with an acute decrease in fetal movements during the previous 12-hour period. A previous pregnancy had resulted in an early spontaneous aborti…
View article: Rosiglitazone-Mediated Activation of PPARγ Restores HO1 Expression in the Human Preeclamptic Placenta
Rosiglitazone-Mediated Activation of PPARγ Restores HO1 Expression in the Human Preeclamptic Placenta Open
BACKGROUND: Preeclampsia is a hypertensive disorder of pregnancy characterized by chronic placental ischemia and suppression of proangiogenic proteins, causing oxidative stress, hypertension, and maternal systemic organ damage. The transcr…
View article: Inpatient vs outpatient management of pregnancies with vasa previa: A historical cohort study
Inpatient vs outpatient management of pregnancies with vasa previa: A historical cohort study Open
Introduction Vasa previa, a condition where unprotected fetal blood vessels lie in proximity to the internal cervical opening, is a potentially lethal obstetric complication. The precarious situation of these vessels increases the risk of …
View article: Placental Pathology and Pregnancy Complications
Placental Pathology and Pregnancy Complications Open
Placental pathology assessment following delivery provides an opportunity to identify the presence and type of disease that can mediate major obstetrical complications, especially in cases where the fetus is growth-restricted, born prematu…
View article: Engaging pregnant individuals and healthcare professionals in an international mixed methods study to develop a core outcome set for studies on placenta accreta spectrum disorder (COPAS): a study protocol
Engaging pregnant individuals and healthcare professionals in an international mixed methods study to develop a core outcome set for studies on placenta accreta spectrum disorder (COPAS): a study protocol Open
Introduction Placenta accreta spectrum (PAS) disorder is a life-threatening condition that may result in serious maternal complications, including mortality. The placenta which is pathologically adherent to the uterine wall, places individ…
View article: Peripheral cord insertion is associated with adverse pregnancy outcome only when accompanied by clinically significant placental pathology
Peripheral cord insertion is associated with adverse pregnancy outcome only when accompanied by clinically significant placental pathology Open
Objective To examine the relationship between umbilical cord insertion site, placental pathology and adverse pregnancy outcome in a cohort of normal and complicated pregnancies. Methods Sonographic measurement of the cord insertion and det…
View article: Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring
Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring Open
Maternal exposure to polystyrene nanoplastics impact postnatal brain development in mouse offspring. This work motivates further studies to determine the levels of nanoplastics in the environment.
View article: Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies
Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies Open
National Institute for Health and Care Research, Wellbeing of Women.
View article: Contribution of Second Trimester Sonographic Placental Morphology to Uterine Artery Doppler in the Prediction of Placenta-Mediated Pregnancy Complications
Contribution of Second Trimester Sonographic Placental Morphology to Uterine Artery Doppler in the Prediction of Placenta-Mediated Pregnancy Complications Open
Background: Second-trimester uterine artery Doppler is a well-established tool for the prediction of preeclampsia and fetal growth restriction. At delivery, placentas from affected pregnancies may have gross pathologic findings. Some of th…