John Kjekshus
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View article: Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis
Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis Open
British Heart Foundation, UK Medical Research Council, and Australian National Health and Medical Research Council.
View article: Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials Open
British Heart Foundation, Medical Research Council, Australian National Health and Medical Research Council.
View article: Assessing the Role of Rare Genetic Variation in Patients With Heart Failure
Assessing the Role of Rare Genetic Variation in Patients With Heart Failure Open
An increased burden of diagnostic mendelian cardiomyopathy variants in a broad group of patients with HF of mostly ischemic etiology compared with controls was observed. This work provides further evidence that mendelian genetic conditions…
View article: Impact of Renal Impairment on Beta-Blocker Efficacy in Patients With Heart Failure
Impact of Renal Impairment on Beta-Blocker Efficacy in Patients With Heart Failure Open
Patients with heart failure, left ventricular ejection fraction <50% and sinus rhythm should receive beta-blocker therapy even with moderate or moderately severe renal dysfunction.
View article: Treatment with insulin is associated with worse outcome in patients with chronic heart failure and diabetes
Treatment with insulin is associated with worse outcome in patients with chronic heart failure and diabetes Open
Aims Up to one‐third of patients with diabetes mellitus and heart failure (HF) are treated with insulin. As insulin causes sodium retention and hypoglycaemia, its use might be associated with worse outcomes. Methods and results We examined…
View article: Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials
Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials Open
Aims Recent guidelines recommend that patients with heart failure and left ventricular ejection fraction (LVEF) 40–49% should be managed similar to LVEF ≥ 50%. We investigated the effect of beta-blockers according to LVEF in double-blind, …
View article: Declining Risk of Sudden Death in Heart Failure
Declining Risk of Sudden Death in Heart Failure Open
Rates of sudden death declined substantially over time among ambulatory patients with heart failure with reduced ejection fraction who were enrolled in clinical trials, a finding that is consistent with a cumulative benefit of evidence-bas…
View article: A history of diabetes predicts outcomes following myocardial infarction: an analysis of the 28 771 patients in the High‐Risk <scp>MI</scp> Database
A history of diabetes predicts outcomes following myocardial infarction: an analysis of the 28 771 patients in the High‐Risk <span>MI</span> Database Open
Aims To examine the impact of diabetes mellitus on long‐term clinical outcomes in patients with myocardial infarction ( MI ) complicated by clinical signs of heart failure ( HF ) or left ventricular dysfunction ( LVD ). Methods and results…
View article: High-Intensity Interval Training in Patients With Heart Failure With Reduced Ejection Fraction
High-Intensity Interval Training in Patients With Heart Failure With Reduced Ejection Fraction Open
Background: Small studies have suggested that high-intensity interval training (HIIT) is superior to moderate continuous training (MCT) in reversing cardiac remodeling and increasing aerobic capacity in patients with heart failure with red…
View article: Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction
Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction Open
Aim We aimed to study the relationships of loop diuretic dose with renal function and clinical outcomes in patients with chronic heart failure ( HF ). Methods and results Loop diuretic dose at baseline was recorded in patients included in …
View article: Secreted Frizzled Related Protein 3 in Chronic Heart Failure: Analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)
Secreted Frizzled Related Protein 3 in Chronic Heart Failure: Analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA) Open
http://www.clinicaltrials.gov NCT00206310.
View article: Inflammation: Friend and Foe
Inflammation: Friend and Foe Open
Activation of inflammatory reactions by the immune system is of vital importance to the preservation of cellular and organ integrity in a hostile environment. It is a complex and fine-tuned mechanism. Insufficient response may cause immuno…
View article: Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation
Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation Open
Background— Our aim was to describe the incidence and predictors of stroke in patients who have heart failure without atrial fibrillation (AF). Methods and Results— We pooled 2 contemporary heart failure trials, the Controlled Rosuvastatin…
View article: Do statins reduce the risk of myocardial infarction in patients with heart failure? A pooled individual‐level reanalysis of CORONA and GISSI‐HF
Do statins reduce the risk of myocardial infarction in patients with heart failure? A pooled individual‐level reanalysis of CORONA and GISSI‐HF Open
Aims Current guidelines do not explicitly recommend statin use in heart failure ( HF ). Relatively low numbers of atherothrombotic events among HF patients, in the context of their elevated competing risks for non‐atherothrombotic causes o…
View article: Telomere length and outcomes in ischaemic heart failure: data from the <scp>COntrolled ROsuvastatin multiNAtional</scp> Trial in Heart Failure (<scp>CORONA</scp>)
Telomere length and outcomes in ischaemic heart failure: data from the <span>COntrolled ROsuvastatin multiNAtional</span> Trial in Heart Failure (<span>CORONA</span>) Open
Aims Leucocyte telomere length is considered a marker of biological ageing and has been suggested to be shorter in patients with CAD and heart failure compared with healthy controls. The aim of this study was to determine whether telomere …