John Kough
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View article: Impact of Food Matrices on Digestibility of Allergens and Poorly Allergenic Homologs
Impact of Food Matrices on Digestibility of Allergens and Poorly Allergenic Homologs Open
Background Protease resistance is considered a risk factor for allergenicity of proteins, although the correlation is low. It is nonetheless a part of the weight-of-evidence approach, proposed by Codex, for assessing the allergenicity risk…
View article: The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement
The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement Open
Motivation: The availability of databases identifying allergenic proteins via a transparent and consensus-based scientific approach is of prime importance to support the safety review of genetically-modified foods and feeds, and public saf…
View article: Functional classification of protein toxins as a basis for bioinformatic screening
Functional classification of protein toxins as a basis for bioinformatic screening Open
Proteins are fundamental to life and exhibit a wide diversity of activities, some of which are toxic. Therefore, assessing whether a specific protein is safe for consumption in foods and feeds is critical. Simple BLAST searches may reveal …