John J. Fung
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View article: Thomas E. Starzl, M.D., Ph.D—the Sui Generis Medical Pioneer and Mentor
Thomas E. Starzl, M.D., Ph.D—the Sui Generis Medical Pioneer and Mentor Open
As the “Father of Modern Transplantation”, Dr. Starzl pioneered every aspect of organ transplantation: immunosuppression, organ procurement and preservation, tissue matching, surgical transplant technology, and the operational management o…
View article: Presacral Clear Cell Carcinoma of Müllerian Origin 20 Years After Hysterectomy and Bilateral Salpingo‐Oophorectomy: A Case Report and Literature Review
Presacral Clear Cell Carcinoma of Müllerian Origin 20 Years After Hysterectomy and Bilateral Salpingo‐Oophorectomy: A Case Report and Literature Review Open
Primary presacral clear cell carcinoma (CCC) of Müllerian origin is extremely rare. Malignant transformation of endometriosis is a known phenomenon, though typically involving the ovaries or pelvic peritoneum. Retroperitoneal presentation,…
View article: The Mpox Contextual Data Specification Package: A Data Curation Toolkit to Support Collaborative Pathogen Genomic Surveillance
The Mpox Contextual Data Specification Package: A Data Curation Toolkit to Support Collaborative Pathogen Genomic Surveillance Open
The Mpox virus (MPXV) is known to cause severe blisters, swollen lymph nodes, body aches, and other symptoms. Mpox mortality rates vary according to lineage and mostly impact children and immunocompromised individuals. A sudden increase in…
View article: Demise of cadaveric islet transplantation in the USA: Quo Vadis, 1 year after BLA approval and 24 years after the Edmonton breakthrough?
Demise of cadaveric islet transplantation in the USA: Quo Vadis, 1 year after BLA approval and 24 years after the Edmonton breakthrough? Open
More than a year after the Biological License Application (BLA) approval for CellTrans, cadaveric islet transplantation remains in demise in the United States (U.S.). While the therapy is unavailable to Americans, it is already a standard …
View article: Detection of atypical bacteria, including <i>Mycoplasma pneumoniae</i>, British Columbia, Canada, 2013–2023
Detection of atypical bacteria, including <i>Mycoplasma pneumoniae</i>, British Columbia, Canada, 2013–2023 Open
Background: Global reports suggest heightened Mycoplasma pneumoniae (Mp) activity during the fall of 2023. However, it is unclear how testing strategy changes and preventative measures implemented during the COVID-19 pandemic influenced th…
View article: Impact of donor-recipient sex-matching patterns on liver transplantation outcomes: a cohort study based on United Network of Organ Sharing data
Impact of donor-recipient sex-matching patterns on liver transplantation outcomes: a cohort study based on United Network of Organ Sharing data Open
Donor-recipient sex-matching patterns significantly influence long-term LT outcomes. The grading system provides potential value to amend allocation process and optimize organ utility.
View article: Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity
Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity Open
While high-throughput (HTP) assays have been proposed as platforms to rapidly assess reproductive toxicity, there is currently a lack of established assays that specifically address germline development/function and fertility. We assessed …
View article: The demise of islet allotransplantation in the United States: A call for an urgent regulatory update
The demise of islet allotransplantation in the United States: A call for an urgent regulatory update Open
Islet allotransplantation in the United States (US) is facing an imminent demise. Despite nearly three decades of progress in the field, an archaic regulatory framework has stymied US clinical practice. Current regulations do not reflect t…
View article: Piperacillin/tazobactam for surgical prophylaxis during pancreatoduodenectomy: meta-analysis
Piperacillin/tazobactam for surgical prophylaxis during pancreatoduodenectomy: meta-analysis Open
Background Pancreatoduodenectomy is associated with an increased incidence of surgical-site infections, often leading to a significant rise in morbidity and mortality. This trend underlines the inadequacy of traditional antibiotic prophyla…
View article: Role of Transarterial Radioembolization in Management of HCC
Role of Transarterial Radioembolization in Management of HCC Open
Transarterial Radioembolization (TARE) is an emerging therapy for the management of hepatocellular carcinoma (HCC). Radioactive Y90 can be loaded onto glass or resin microparticles for intra-arterial selective internal radiation therapy. T…
View article: Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: A randomized, open-label, clinical trial
Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: A randomized, open-label, clinical trial Open
Background and Aims: In liver transplantation, cold preservation induces ischemia, resulting in significant reperfusion injury. Hypothermic oxygenated machine perfusion (HMP-O 2 ) has shown benefits compared to static cold storage (SCS) by…
View article: The Seattle Heart Failure Model in Kidney Transplant Recipients
The Seattle Heart Failure Model in Kidney Transplant Recipients Open
Cardiovascular disease is the leading cause of mortality following kidney transplantation. Heart failure affects 17–21% of patients with chronic kidney disease and increases along with time receiving dialysis. The Seattle Heart Failure Mod…
View article: EP19.08: Longitudinal evaluation of cervical length and shear wave elastography in women with spontaneous preterm birth
EP19.08: Longitudinal evaluation of cervical length and shear wave elastography in women with spontaneous preterm birth Open
with amnionic membrane bulging into vagina after the first cervical cerclage
View article: Comparing High- and Low-Model for End-Stage Liver Disease Living-Donor Liver Transplantation to Determine Clinical Efficacy: A Systematic Review and Meta-Analysis (CHALICE Study)
Comparing High- and Low-Model for End-Stage Liver Disease Living-Donor Liver Transplantation to Determine Clinical Efficacy: A Systematic Review and Meta-Analysis (CHALICE Study) Open
Introduction: Various studies have demonstrated that low-Model for End-Stage Liver Disease (MELD) living-donor liver transplant (LDLT) recipients have better outcomes with improved patient survival than deceased-donor liver transplantation…
View article: Biliary atresia and liver transplantation in the United States: A contemporary analysis
Biliary atresia and liver transplantation in the United States: A contemporary analysis Open
Background Biliary atresia (BA) remains the number one indication for paediatric liver transplantation (LT) worldwide but is an uncommon indication for older LT recipients. The impact of recent donor allocation changes, pervasive organ sho…
View article: Dynamic evaluation based on acute-on-chronic liver failure predicts survival of patients after liver transplantation: a cohort study
Dynamic evaluation based on acute-on-chronic liver failure predicts survival of patients after liver transplantation: a cohort study Open
Background and aims: Dynamic evaluation of critically ill patients is the key to predicting their outcomes. Most scores based on the Model for End-stage Liver Disease (MELD) and acute-on-chronic liver failure (ACLF) utilize point-in-time a…
View article: Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies
Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies Open
Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation duri…
View article: Microbiome compositions and fecal metabolite concentrations predict post-operative infection in liver transplant recipients
Microbiome compositions and fecal metabolite concentrations predict post-operative infection in liver transplant recipients Open
Background Liver transplantation (LT) is associated with postoperative infections caused by antibiotic-resistant bacterial pathogens that reside in the intestine. An intact intestinal microbiome suppresses expansion of enteric pathogens, h…
View article: Impact of COVID-19 on Patients’ Attitudes and Perceptions of Dental Health Services: A Questionnaire Based Study in an Australian University Dental Clinic
Impact of COVID-19 on Patients’ Attitudes and Perceptions of Dental Health Services: A Questionnaire Based Study in an Australian University Dental Clinic Open
COVID-19, the global pandemic, has significantly interrupted the provision of oral health care to many individuals. This study aims to evaluate patients’ attitudes to and perceptions of dental visits in the COVID-19 pandemic and assess if …
View article: The Effect of Normothermic Machine Perfusion on the Immune Profile of Donor Liver
The Effect of Normothermic Machine Perfusion on the Immune Profile of Donor Liver Open
Background Normothermic machine perfusion (NMP) allows viability assessment and potential resuscitation of donor livers prior to transplantation. The immunological effect of NMP on liver allografts is undetermined, with potential implicati…
View article: Which cava anastomotic techniques are optimal regarding immediate and short‐term outcomes after liver transplantation: A systematic review of the literature and expert panel recommendations
Which cava anastomotic techniques are optimal regarding immediate and short‐term outcomes after liver transplantation: A systematic review of the literature and expert panel recommendations Open
Background It has long been debated whether cava anastomosis should be performed with the piggyback technique or cava replacement, with or without veno‐venous bypass (VVB), with or without temporary portocaval shunt (PCS) in the setting of…
View article: Donor leukocyte trafficking during human ex vivo lung perfusion
Donor leukocyte trafficking during human ex vivo lung perfusion Open
Background Ex vivo lung perfusion (EVLP) is used to assess and preserve lungs prior to transplantation. However, its inherent immunomodulatory effects are not completely understood. We examine perfusate and tissue compartments to determine…