John L. Krstenansky
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View article: Simplified Nomenclature and Projection Diagrams of Chiral Cubane Analogs
Simplified Nomenclature and Projection Diagrams of Chiral Cubane Analogs Open
A simplified nomenclature for chiral cubane analogs is proposed where analogs with a clockwise systematic continuous numbering of the cubane core are designated as (C)-, and analogs with an anticlockwise continuous numbering of the cubane …
View article: Synthesis, structure, in vitro pharmacology, and in vivo activity of <i>trans</i>‐3,<scp>4‐dichloro‐<i>N</i></scp>‐[[1‐(dimethylamino)‐4‐phenylcyclohexyl]methyl]‐benzamide (<scp>AP01</scp>; <scp>4‐phenyl‐AH</scp>‐7921), a novel mixed μ‐/κ‐opioid
Synthesis, structure, in vitro pharmacology, and in vivo activity of <i>trans</i>‐3,<span>4‐dichloro‐<i>N</i></span>‐[[1‐(dimethylamino)‐4‐phenylcyclohexyl]methyl]‐benzamide (<span>AP01</span>; <span>4‐phenyl‐AH</span>‐7921), a novel mixed μ‐/κ‐opioid Open
Analogs of non‐fentanyl novel synthetic opioids (NSO) with modifications that fall outside of established structure–activity relationships (SARs) for that class of drugs create the question whether or not it should be considered an analog,…
View article: ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics
ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics Open
The COVID-19 pandemic that began in late 2019 continues with new challenges arising due to antigenic drift as well as individuals who cannot or choose not to take the vaccine. There is therefore an urgent need for additional therapies that…
View article: Synthesis and pharmacological characterization of ethylenediamine synthetic opioids in human μ‐opiate receptor 1 (OPRM1) expressing cells
Synthesis and pharmacological characterization of ethylenediamine synthetic opioids in human μ‐opiate receptor 1 (OPRM1) expressing cells Open
Opioids are powerful analgesics acting via the human μ‐opiate receptor (hMOR). Opioid use is associated with adverse effects such as tolerance, addiction, respiratory depression, and constipation. Two synthetic opioids, AH‐7921 and U‐47700…
View article: Ethylenediamine synthetic opioids
Ethylenediamine synthetic opioids Open
Series of analogs of synthetic opioids AH-7921 and U-47700. Spectral data saved as zip file. (GC-MS, IR, NMR, and Raman 1064). The set contains 17 analogs of AH-7921 and 26 analogs of U-47700 and an accompanying docx file gives the name an…
View article: Volume 13, Issue 4
Volume 13, Issue 4 Open
A comparison of the effectiveness of two synthetic methods was done for a green chemistry method using an ionic liquid-based solvent relative to a conventional method using organic solvents for the N-alkylation of indole.The green method u…
View article: Green Chemistry: Comparison of Ionic Liquid vs Conventional Solvent for Indole Alkylation
Green Chemistry: Comparison of Ionic Liquid vs Conventional Solvent for Indole Alkylation Open
A comparison of the effectiveness of two synthetic methods was done for a green chemistry method using an ionic liquid-based solvent relative to a conventional method using organic solvents for the N-alkylation of indole. The green method …