John L. Sievenpiper
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View article: Sarcopenic diabetes is an under-recognized and unmet clinical priority. A call for action from the European Society for Clinical Nutrition and Metabolism and the Diabetes Nutrition Study Group
Sarcopenic diabetes is an under-recognized and unmet clinical priority. A call for action from the European Society for Clinical Nutrition and Metabolism and the Diabetes Nutrition Study Group Open
Diabetes mellitus is a systemic chronic disease with growing prevalence and potential multiorgan complications leading to clinical, social, and economic burdens. Nutritional and metabolic derangements are important components of both type …
View article: Optimizing GLP-1 therapies for obesity and diabetes management
Optimizing GLP-1 therapies for obesity and diabetes management Open
View article: The Relationship Between Regulatory Frameworks for Protein Content Claims for Plant Protein Foods and the Nutrient Intakes of Canadian Adults
The Relationship Between Regulatory Frameworks for Protein Content Claims for Plant Protein Foods and the Nutrient Intakes of Canadian Adults Open
Background: The inability to assign a protein content claim (PCC) to plant foods may impede efforts from Canada’s Food Guide to increase consumption of plant protein. A systematic application of PCC frameworks from other regions to Canadia…
View article: Translating Cardiovascular Clinical Practice Guidelines on Nutrition Therapy: Validation of the Portfolio Diet Toolkit for Healthcare Providers
Translating Cardiovascular Clinical Practice Guidelines on Nutrition Therapy: Validation of the Portfolio Diet Toolkit for Healthcare Providers Open
View article: Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials
Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials Open
Objective To assess the effect of intermittent fasting diets, with continuous energy restriction or unrestricted (ad-libitum) diets on intermediate cardiometabolic outcomes from randomised clinical trials. Design Systematic review and netw…
View article: Empowering Healthcare Providers: Usability, Quality, and Practical Clinical Application of the Portfolio Diet Program for Evidence-Based Nutrition Care
Empowering Healthcare Providers: Usability, Quality, and Practical Clinical Application of the Portfolio Diet Program for Evidence-Based Nutrition Care Open
View article: Acceptability of a Web-Based Health App (PortfolioDiet.app) to Translate a Nutrition Therapy for Cardiovascular Disease in High-Risk Adults: Mixed Methods Randomized Ancillary Pilot Study
Acceptability of a Web-Based Health App (PortfolioDiet.app) to Translate a Nutrition Therapy for Cardiovascular Disease in High-Risk Adults: Mixed Methods Randomized Ancillary Pilot Study Open
Background The Portfolio Diet is a dietary pattern for cardiovascular disease (CVD) risk reduction with 5 key categories including nuts and seeds; plant protein from specific food sources; viscous fiber sources; plant sterols; and plant-de…
View article: Dietary Guidance, Sensory, Health and Safety Considerations When Choosing Low and No-Calorie Sweeteners
Dietary Guidance, Sensory, Health and Safety Considerations When Choosing Low and No-Calorie Sweeteners Open
The growing global focus on the adverse health conditions associated with excessive sugar consumption has prompted health and policy organizations as well as the public to take a more mindful approach to health and wellness. In response, f…
View article: Non-nutritive Sweeteners and Health: Reconciling Evidence and Interrogating Guideline Disconnects
Non-nutritive Sweeteners and Health: Reconciling Evidence and Interrogating Guideline Disconnects Open
View article: Antioxidant and anti-inflammatory activities, bioaccessibility, transmembrane transport of major phenolics from selected floral honeys using Caco-2 BBe1 cell model
Antioxidant and anti-inflammatory activities, bioaccessibility, transmembrane transport of major phenolics from selected floral honeys using Caco-2 BBe1 cell model Open
View article: Perspective: Current Scientific Evidence and Research Strategies in the Role of Almonds in Cardiometabolic Health
Perspective: Current Scientific Evidence and Research Strategies in the Role of Almonds in Cardiometabolic Health Open
Almonds are consumed by individuals around the world. Because almonds are rich in protein, unsaturated fatty acids, and fiber, a significant amount of research has been conducted on their role in affecting various cardiometabolic endpoints…
View article: Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
View article: No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial
No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial Open
Dietary inorganic nitrate lowers blood pressure (BP) in healthy individuals through improved nitric oxide (NO) bioavailability. However, there is limited evidence examining the long-term effects of dietary nitrate for managing hypertension…
View article: The Portfolio Diet and HbA1c in Adults Living with Type 2 Diabetes Mellitus: A Patient-Level Pooled Analysis of Two Randomized Dietary Trials
The Portfolio Diet and HbA1c in Adults Living with Type 2 Diabetes Mellitus: A Patient-Level Pooled Analysis of Two Randomized Dietary Trials Open
(1) Background: The Portfolio Diet, a dietary pattern of cholesterol-lowering foods, is also rich in low glycemic index (GI) foods. While strong evidence supports clinically meaningful reductions in cholesterol, evidence on the relationshi…
View article: A systematic review and meta-analysis of randomized trials of substituting soymilk for cow’s milk and intermediate cardiometabolic outcomes: understanding the impact of dairy alternatives in the transition to plant-based diets on cardiometabolic health
A systematic review and meta-analysis of randomized trials of substituting soymilk for cow’s milk and intermediate cardiometabolic outcomes: understanding the impact of dairy alternatives in the transition to plant-based diets on cardiometabolic health Open
View article: WHO guideline on the use of non-sugar sweeteners: a need for reconsideration
WHO guideline on the use of non-sugar sweeteners: a need for reconsideration Open
The World Health Organization’s (WHO) Nutrition and Food Safety Department recently released a guideline on the use of non-sugar sweeteners (NSS) [1] based upon the analysis of a WHO-commissioned systematic review and meta-analysis (SRMA) …
View article: WHO guideline on the use of non-sugar sweeteners: a need for reconsideration
WHO guideline on the use of non-sugar sweeteners: a need for reconsideration Open
The World Health Organization’s (WHO) Nutrition and Food Safety Department recently released a guideline on the use of non-sugar sweeteners (NSS) [1] based upon the analysis of a WHO-commissioned systematic review and meta-analysis (SRMA) …
View article: Glycemic Index Versus Wheat Fiber on Arterial Wall Damage in Diabetes: A Randomized Controlled Trial
Glycemic Index Versus Wheat Fiber on Arterial Wall Damage in Diabetes: A Randomized Controlled Trial Open
Objective: High cereal fiber and low-glycemic index (GI) diets are associated with reduced cardiovascular disease (CVD) risk in cohort studies. Clinical trial evidence on event incidence is lacking. Therefore, to make tria…
View article: Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study
Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study Open
Background Water intake and hydration status have been suggested to impact cognition; however, longitudinal evidence is limited and often inconsistent. This study aimed to longitudinally assess the association between hydr…
View article: Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study
Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study Open
Background Water intake and hydration status have been suggested to impact cognition; however, longitudinal evidence is limited and often inconsistent. This study aimed to longitudinally assess the association between hydr…
View article: Repeated administration of nitrate-rich interventions on blood pressure and arterial stiffness: A systematic review and meta-analysis of randomized controlled trials in individuals with and without cardiovascular disease risk
Repeated administration of nitrate-rich interventions on blood pressure and arterial stiffness: A systematic review and meta-analysis of randomized controlled trials in individuals with and without cardiovascular disease risk Open
Objective: We aim to synthesize effects of repeated administration (≥3 days) of inorganic nitrate on blood pressure and arterial stiffness measures. Methods: We conducted a systematic review and meta-analy…
View article: DASH Dietary Pattern and Cardiometabolic Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses
DASH Dietary Pattern and Cardiometabolic Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses Open
Background: The Dietary Approaches to Stop Hypertension (DASH) dietary pattern, which emphasizes fruit, vegetables, fat-free/low-fat dairy, whole grains, nuts and legumes, and limits saturated fat, cholesterol, red and processed meats, swe…
View article: Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials
Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials Open
Background The evidence for the Portfolio dietary pattern, a plant-based dietary pattern that combines recognized cholesterol-lowering foods (nuts, plant protein, viscous fibre, plant sterols), has not been summarized. Objective To updat…
View article: Nuts in the Prevention and Management of Type 2 Diabetes
Nuts in the Prevention and Management of Type 2 Diabetes Open
Diabetes is a continuously growing global concern affecting >10% of adults, which may be mitigated by modifiable lifestyle factors. Consumption of nuts and their inclusion in dietary patterns has been associated with a range of beneficial …
View article: Almond Bioaccessibility in a Randomized Crossover Trial: Is a Calorie a Calorie?
Almond Bioaccessibility in a Randomized Crossover Trial: Is a Calorie a Calorie? Open
Objective To investigate the energy and macronutrient bioaccessibility of almonds in individuals with hyperlipidemia. Methods In a previously reported randomized crossover trial, men and postmenopausal women with hyperlipidemia incorporate…
View article: Weight management using meal replacements and cardiometabolic risk reduction in individuals with pre-diabetes and features of metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials
Weight management using meal replacements and cardiometabolic risk reduction in individuals with pre-diabetes and features of metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials Open
This review synthesized the evidence from randomized controlled trials comparing the effect of meal replacements (MRs) as part of a weight loss intervention with conventional food-based weight loss diets on cardiometabolic risk in individu…
View article: Effect of lowering the glycemic load with canola oil on glycemic control and cardiovascular risk factors: a randomized controlled trial
Effect of lowering the glycemic load with canola oil on glycemic control and cardiovascular risk factors: a randomized controlled trial Open
OBJECTIVE Despite their independent cardiovascular disease (CVD) advantages, effects of α-linolenic acid (ALA), monounsaturated fatty acid (MUFA), and low-glycemic-load (GL) diets have not been assessed in combination. We therefore determi…
View article: Does conventional early life academic excellence predict later life scientific discovery? An assessment of the lives of great medical innovators
Does conventional early life academic excellence predict later life scientific discovery? An assessment of the lives of great medical innovators Open
Background Perhaps, as never before, we need innovators. With our growing population numbers, and with increasing pressures on our education systems, are we in danger of becoming more rigid and formulaic and increasingly inhibiting innovat…
View article: DASH Dietary Pattern and Cardiometabolic Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses
DASH Dietary Pattern and Cardiometabolic Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses Open
Background: The Dietary Approaches to Stop Hypertension (DASH) dietary pattern, which emphasizes fruit, vegetables, fat-free/low-fat dairy, whole grains, nuts and legumes, and limits saturated fat, cholesterol, red and processed meats, swe…
View article: Does conventional early life academic excellence predict later life scientific discovery? An assessment of the lives of great medical innovators
Does conventional early life academic excellence predict later life scientific discovery? An assessment of the lives of great medical innovators Open
Background Perhaps, as never before, we need innovators. With our growing population numbers, and with increasing pressures on our education systems, are we in danger of becoming more rigid and formulaic and increasingly inhibiting innovat…