Richard J. Lamont
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View article: From defense to demise: autophagy-induced neutrophil death after peptoanaerobacter stomatis challenge 3834
From defense to demise: autophagy-induced neutrophil death after peptoanaerobacter stomatis challenge 3834 Open
Description Neutrophil dysregulation plays a crucial role in the onset and progression of periodontitis (PD). High throughput culture-independent techniques applied to human dental plaque identified Peptoanaerobacter stomatis (Ps) as a not…
View article: Tyrosine phosphorylation coupling of one-carbon metabolism and virulence in an endogenous pathogen
Tyrosine phosphorylation coupling of one-carbon metabolism and virulence in an endogenous pathogen Open
Endogenous pathogens can constrain virulence to ensure survival in the host. Pathogenic state can be controlled by metabolic responses to the prevailing microenvironment; however, the coupling and effector mechanisms are not well understoo…
View article: The Nox2 NADPH oxidase regulates neutrophilic inflammation in the oral cavity
The Nox2 NADPH oxidase regulates neutrophilic inflammation in the oral cavity Open
The leukocyte NADPH oxidase 2 (NOX2) is an important regulator of inflammatory responses, independent of its antimicrobial activity. Inactivating mutations in NOX2 cause chronic granulomatous disease (CGD), a severe immunodeficiency associ…
View article: Structure of the T9SS PorKN ring complex reveals conformational plasticity based on the repurposed FGE fold
Structure of the T9SS PorKN ring complex reveals conformational plasticity based on the repurposed FGE fold Open
The type IX secretion system (T9SS) is a protein secretion machinery unique to the Bacteroidetes-Chlorobi-Fibrobacteres superphylum, which plays crucial roles in bacterial pathogenesis and gliding motility. It is composed of >15 proteins, …
View article: Episymbiotic Saccharibacteria suppresses epithelial immunoactivation through Type IV pili and TLR2 dependent endocytosis
Episymbiotic Saccharibacteria suppresses epithelial immunoactivation through Type IV pili and TLR2 dependent endocytosis Open
Summary Saccharibacteria are episymbionts that require host-bacteria to grow. They are positively associated with inflammatory diseases within the human microbiome, yet their mechanisms for interacting with the human host and contributing …
View article: <i>Filifactor alocis</i> Pathogenicity Requires TLR2 and the Oral Microbiome
<i>Filifactor alocis</i> Pathogenicity Requires TLR2 and the Oral Microbiome Open
Enrichment of the oral microorganism Filifactor alocis is strongly associated with the progression of periodontitis. However, F. alocis is part of a complex dysbiotic microbial community, and the organism’s direct pathogenic potential rema…
View article: Virion stripping: A new role for bacterial proteases
Virion stripping: A new role for bacterial proteases Open
We demonstrate that proteases produced by the oro-pharyngeal bacterial colonizer Porphyromonas gingivalis (Pg) reduce viral burden and modulate host interferon responses during respiratory syncytial virus (RSV) infection. Several oral bact…
View article: Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen
Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen Open
Endogenous pathogens can constrain virulence to ensure survival in the host. Pathogenic state can be controlled by metabolic responses to the prevailing microenvironment; however, the coupling and effector mechanisms are not well understoo…
View article: Corrigendum: TLR2 activation by Porphyromonas gingivalis requires both PPAD activity and fimbriae
Corrigendum: TLR2 activation by Porphyromonas gingivalis requires both PPAD activity and fimbriae Open
[This corrects the article DOI: 10.3389/fimmu.2022.823685.].
View article: The polymicrobial pathogenicity of Porphyromonas gingivalis
The polymicrobial pathogenicity of Porphyromonas gingivalis Open
Accumulating microbiome data and mechanistic studies in vitro and in vivo have refined our understanding of the oral microbiota as a functionally integrated polymicrobial community. Emergent properties of these communities are driven to a …
View article: Interspecies metabolite transfer fuels the methionine metabolism of <i>Fusobacterium nucleatum</i> to stimulate volatile methyl mercaptan production
Interspecies metabolite transfer fuels the methionine metabolism of <i>Fusobacterium nucleatum</i> to stimulate volatile methyl mercaptan production Open
Halitosis can have a significant impact on the social life of affected individuals. Among oral odor compounds, CH 3 SH has a low olfactory threshold and halitosis is a result of its production. Recently, there has been a growing interest i…
View article: Organotypic model of the gingiva for studying bacterial and viral pathogens implicated in periodontitis
Organotypic model of the gingiva for studying bacterial and viral pathogens implicated in periodontitis Open
Presented OTG model constitutes a simple and convenient tool to study the interaction between bacterial and viral pathogens within the gingival tissue, including penetration, persistence and biofilm formation. It is also suitable to examin…
View article: Social networking at the microbiome-host interface
Social networking at the microbiome-host interface Open
Microbial species colonizing host ecosystems in health or disease rarely do so alone. Organisms conglomerate into dynamic heterotypic communities or biofilms in which interspecies and interkingdom interactions drive functional specializati…
View article: Illuminating the oral microbiome: cellular microbiology
Illuminating the oral microbiome: cellular microbiology Open
Epithelial cells line mucosal surfaces such as in the gingival crevice and provide a barrier to the ingress of colonizing microorganisms. However, epithelial cells are more than a passive barrier to microbial intrusion, and rather constitu…
View article: One‐carbon metabolism and microbial pathogenicity
One‐carbon metabolism and microbial pathogenicity Open
One‐carbon metabolism (OCM) pathways are responsible for several functions, producing a number of one‐carbon unit intermediates (formyl, methylene, methenyl, methyl) that are required for the synthesis of various amino acids and other biom…
View article: Impact of Polymicrobial Infection on Fitness of Streptococcus gordonii <i>In Vivo</i>
Impact of Polymicrobial Infection on Fitness of Streptococcus gordonii <i>In Vivo</i> Open
Bacteria responsible for diseases originating at oral mucosal membranes assemble into polymicrobial communities. However, we know little regarding the fitness determinants of the organisms that initiate community formation.
View article: Selenomonas sputigena Interactions with Gingival Epithelial Cells That Promote Inflammation
Selenomonas sputigena Interactions with Gingival Epithelial Cells That Promote Inflammation Open
Increased prevalence and abundance of Selenomonas sputigena have been associated with periodontitis, a chronic inflammatory disease of tooth-supporting tissues, for more than 50 years. Over the past decade, molecular surveys of periodontal…
View article: Selective activation of TGFβ signaling by <i>P. gingivalis</i>-mediated upregulation of GARP aggravates esophageal squamous cell carcinoma.
Selective activation of TGFβ signaling by <i>P. gingivalis</i>-mediated upregulation of GARP aggravates esophageal squamous cell carcinoma. Open
Aberrant TGFβ signaling plays critical roles in the progression of multiple cancers; however, the functional mechanism of this signaling network in the infectious milieu of Esophageal Squamous Cell Carcinoma (ESCC) remains largely unknown.…
View article: Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors
Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors Open
The PglZ family of proteins belongs to the alkaline phosphatase superfamily, which consists of metallohydrolases with limited sequence identity but similar metal-coordination architectures in otherwise divergent active sites. Proteins with…
View article: Treponema denticola Induces Interleukin-36γ Expression in Human Oral Gingival Keratinocytes via the Parallel Activation of NF-κB and Mitogen-Activated Protein Kinase Pathways
Treponema denticola Induces Interleukin-36γ Expression in Human Oral Gingival Keratinocytes via the Parallel Activation of NF-κB and Mitogen-Activated Protein Kinase Pathways Open
The oral epithelial barrier acts as both a physical barrier to the abundant oral microbiome and a sentry for the immune system that, in health, constrains the accumulation of the polymicrobial plaque biofilm. The immune homeostasis during …
View article: Fusobacterium nucleatum Metabolically Integrates Commensals and Pathogens in Oral Biofilms
Fusobacterium nucleatum Metabolically Integrates Commensals and Pathogens in Oral Biofilms Open
Periodontitis is caused by a pathogenic shift in subgingival biofilm ecosystems, which is accompanied by alterations in microbiome composition and function, including changes in the metabolic activity of the biofilm, which comprises multip…
View article: Porphyromonas gingivalis Tyrosine Kinase Is a Fitness Determinant in Polymicrobial Infections
Porphyromonas gingivalis Tyrosine Kinase Is a Fitness Determinant in Polymicrobial Infections Open
Many pathogenic microbial ecosystems are polymicrobial, and community function can be shaped by interbacterial interactions. Little is known, however, regarding the genetic determinants required for fitness in heterotypic community environ…
View article: Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis
Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis Open
Gingipain cysteine proteases are essential virulence factors of Porphyromonas gingivalis , an oral bacterium implicated in development of periodontitis. Gingipains diffusing from anaerobic periodontal pockets lose proteolytic activity in t…
View article: A unique bacterial secretion machinery with multiple secretion centers
A unique bacterial secretion machinery with multiple secretion centers Open
Significance The newly described type IX secretion systems (T9SSs) translocate virulence factors and can mediate specialized gliding motility among bacterial pathogens of the Fibrobacteres–Chlorobi–Bacterioidetes superphylum. We visualized…
View article: The emerging oral pathogen, <i>Filifactor alocis</i>, extends the functional lifespan of human neutrophils
The emerging oral pathogen, <i>Filifactor alocis</i>, extends the functional lifespan of human neutrophils Open
Periodontitis is a chronic inflammatory infectious disease that affects the integrity of tooth‐supporting tissues and has adverse systemic consequences. Advances in sequencing technologies have uncovered organisms that are exclusively foun…