John Linkhorst
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View article: 3D Membrane Microstructures for Increased Efficiency in Blood‐Gas Transfer
3D Membrane Microstructures for Increased Efficiency in Blood‐Gas Transfer Open
Treating severe lung diseases with extracorporeal membrane oxygenation (ECMO) is often accompanied by serious complications, restricting applicability and adversely affecting outcomes. Membrane oxygenators, based on hollow fiber membranes …
View article: Tailored 3D Lattice Microstructures for Enhanced Functionality in Blood‐Gas Exchange
Tailored 3D Lattice Microstructures for Enhanced Functionality in Blood‐Gas Exchange Open
Current membrane oxygenators for extracorporeal life support (ECLS) are facing their limits regarding gas exchange efficiency and long‐term stability. One aspect adding to these limitations is inhomogeneous blood flow distribution inside t…
View article: Microfluidic Spinning of PEDOT:PSS Microfibers for Nerve Guidance Conduits
Microfluidic Spinning of PEDOT:PSS Microfibers for Nerve Guidance Conduits Open
Peripheral nerve injury is associated with severe loss of life quality, often requiring surgical intervention. Nerve guidance conduits (NGCs) support nerve regeneration by guiding axonal outgrowth and Schwann cell migration. Conductive NGC…
View article: Hierarchically Structured and Tunable Hydrogel Patches: Design, Characterization, and Application
Hierarchically Structured and Tunable Hydrogel Patches: Design, Characterization, and Application Open
Recent studies show the importance of hydrogel geometry for various applications, such as encoding, micromachines, or tissue engineering. However, fabricating hydrogel structures with micrometer‐sized features, advanced geometry, and preci…
View article: Enhanced Hemodynamics of Anisometric TPMS Topology Reduce Blood Clotting in 3D Printed Blood Contactors
Enhanced Hemodynamics of Anisometric TPMS Topology Reduce Blood Clotting in 3D Printed Blood Contactors Open
Artificial organs, such as extracorporeal membrane oxygenators, dialyzers, and hemoadsorber cartridges, face persistent challenges related to the flow distribution within the cartridge. This uneven flow distribution leads to clot formation…
View article: Cell Adhesion and Local Cytokine Control on Protein‐Functionalized PNIPAM‐co‐AAc Hydrogel Microcarriers
Cell Adhesion and Local Cytokine Control on Protein‐Functionalized PNIPAM‐co‐AAc Hydrogel Microcarriers Open
Achieving adequate cell densities remains a major challenge in establishing economic biotechnological and biomedical processes. A possible remedy is microcarrier‐based cultivation in stirred‐tank bioreactors (STBR), which offers a high sur…
View article: Dynamics of the Boundary Layer in Pulsed CO<sub>2</sub> Electrolysis
Dynamics of the Boundary Layer in Pulsed CO<sub>2</sub> Electrolysis Open
Electrochemical reduction of CO 2 poses a vast potential to contribute to a defossilized industry. Despite tremendous developments within the field, mass transport limitations, carbonate salt formation, and electrode degradation mechanisms…
View article: Dynamics of the Boundary Layer in Pulsed CO<sub>2</sub> Electrolysis
Dynamics of the Boundary Layer in Pulsed CO<sub>2</sub> Electrolysis Open
Electrochemical reduction of CO 2 poses a vast potential to contribute to a defossilized industry. Despite tremendous developments within the field, mass transport limitations, carbonate salt formation, and electrode degradation mechanisms…
View article: Temporal resistance fluctuations during the initial filtration period of colloidal matter filtration
Temporal resistance fluctuations during the initial filtration period of colloidal matter filtration Open
Membrane filtration processes with flux reversal for backwashing are employed to manage fouling during colloidal fluid treatment. This flux reversal accompanies filtration cycles where the total resistance increases over time. However, lit…
View article: Porous Anisometric PNIPAM Microgels: Tailored Porous Structure and Thermal Response
Porous Anisometric PNIPAM Microgels: Tailored Porous Structure and Thermal Response Open
The porous structure of microgels significantly influences their properties and, thus, their suitability for various applications, in particular as building blocks for tissue scaffolds. Porosity is one of the crucial features for microgel–…
View article: A Microfluidic Perfusion Culture Setup to Investigate Cell Migration in 3D Constrictions
A Microfluidic Perfusion Culture Setup to Investigate Cell Migration in 3D Constrictions Open
Cell migration is a fundamental process underlying the morphological maturation of organs, but also in disease‐related conditions such as cancer. Cells are able to migrate through crowded space and a tight extracellular matrix (ECM). Passi…
View article: Spatio‐Temporal Electrowetting and Reaction Monitoring in Microfluidic Gas Diffusion Electrode Elucidates Mass Transport Limitations
Spatio‐Temporal Electrowetting and Reaction Monitoring in Microfluidic Gas Diffusion Electrode Elucidates Mass Transport Limitations Open
The use of gas diffusion electrodes (GDEs) enables efficient electrochemical CO 2 reduction and may be a viable technology in CO 2 utilization after carbon capture. Understanding the spatio‐temporal phenomena at the triple‐phase boundary f…
View article: Convective Drying of Porous Media: Comparison of Phase-Field Simulations with Microfluidic Experiments
Convective Drying of Porous Media: Comparison of Phase-Field Simulations with Microfluidic Experiments Open
Convective drying of porous media is central to many engineering applications, ranging from spray drying over water management in fuel cells to food drying. To improve these processes, a deep understanding of drying phenomena in porous med…
View article: Coupled optical-electric monitoring of charge percolation events in carbon flow-electrodes
Coupled optical-electric monitoring of charge percolation events in carbon flow-electrodes Open
The industrial application of electrochemical processes is limited by a variety of challenges, such as catalyst stability and selectivity. However, the question of how to efficiently exploit the entire reactor volume for the process is als…
View article: Transport and clogging dynamics of flexible rods in pore constrictions
Transport and clogging dynamics of flexible rods in pore constrictions Open
A spatio-temporal analysis reveals conditions that contribute to the trajectory and clogging mechanisms of flexible rod-shaped particles in confined flow.
View article: Reactor design via scan line patterning: An implicit approach to create scalable microstructured parts in selective laser melting
Reactor design via scan line patterning: An implicit approach to create scalable microstructured parts in selective laser melting Open
The adaptation of additive manufacturing for chemical flow reactors has recently gained momentum as the methods become more advanced and equipment is increasingly affordable. With the design of periodic open cellular structures (POCS) from…
View article: Impact of the Membrane Structure of the Stationary Phase on Steric Exclusion Chromatography (SXC) of Lentiviral Vectors
Impact of the Membrane Structure of the Stationary Phase on Steric Exclusion Chromatography (SXC) of Lentiviral Vectors Open
For steric exclusion chromatography (SXC), hydrophilic stationary phases are used to capture the target molecule in the presence of polyethylene glycol. The influence of the structure and pore size of the stationary phase on the process re…
View article: Tailoring Pore Networks – Gas Diffusion Electrodes via Additive Manufacturing
Tailoring Pore Networks – Gas Diffusion Electrodes via Additive Manufacturing Open
Additive manufacturing (AM) is a promising alternative to conventional electrode production due to its high freedom of design, excellent reproducibility, and a manifold choice of metals serving as substrates or even electrocatalysts in var…
View article: PEDOT:PSS‐CNT Composite Particles Overcome Contact Resistances in Slurry Electrodes for Flow‐Electrode Capacitive Deionization (Adv. Funct. Mater. 38/2023)
PEDOT:PSS‐CNT Composite Particles Overcome Contact Resistances in Slurry Electrodes for Flow‐Electrode Capacitive Deionization (Adv. Funct. Mater. 38/2023) Open
Flow Electrodes In article number 2303606, John Linkhorst and co-workers demonstrate the high throughput fabrication of highly porous PEDOT:PSS-based hydrogel particles and investigate their application as slurry electrodes for flow-electr…
View article: Continuous Volumetric 3D Printing: Xolography in Flow
Continuous Volumetric 3D Printing: Xolography in Flow Open
Additive manufacturing techniques continue to improve in resolution, geometrical freedom, and production rates, expanding their application range in research and industry. Most established techniques, however, are based on layer‐by‐layer p…
View article: Integrated Biphasic Electrochemical Oxidation of Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid
Integrated Biphasic Electrochemical Oxidation of Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid Open
Production of biobased platform chemicals and polymers\nvia electrochemical\nroutes enables the direct utilization of electrical energy from renewable\nsources. To date, the integration of electrochemical conversions in\nprocess chains rem…
View article: Toward the Next Generation of Neural Iontronic Interfaces
Toward the Next Generation of Neural Iontronic Interfaces Open
Neural interfaces are evolving at a rapid pace owing to advances in material science and fabrication, reduced cost of scalable complementary metal oxide semiconductor (CMOS) technologies, and highly interdisciplinary teams of researchers a…
View article: Peptide-Functionalized Electrospun Meshes for the Physiological Cultivation of Pulmonary Alveolar Capillary Barrier Models in a 3D-Printed Micro-Bioreactor
Peptide-Functionalized Electrospun Meshes for the Physiological Cultivation of Pulmonary Alveolar Capillary Barrier Models in a 3D-Printed Micro-Bioreactor Open
In vitro environments that realize biomimetic scaffolds, cellular composition, physiological shear, and strain are integral to developing tissue models of organ-specific functions. In this study, an in vitro pulmonary alveolar capillary ba…
View article: PEDOT:PSS‐CNT Composite Particles Overcome Contact Resistances in Slurry Electrodes for Flow‐Electrode Capacitive Deionization
PEDOT:PSS‐CNT Composite Particles Overcome Contact Resistances in Slurry Electrodes for Flow‐Electrode Capacitive Deionization Open
Activated carbon (AC) particles constitute the current material of choice concerning the preparation of flow electrodes for flow‐electrode capacitive deionization (FCDI). They are inexpensive, mass‐producible, highly conductive, and exhibi…