John Lisman
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View article: Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs
Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs Open
The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a central regulator of learning and memory, which poses a problem for targeting it therapeutically. Indeed, our study supports prior conclusions that long-term interference with C…
View article: Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory and is neuroprotective in non-rodents
Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory and is neuroprotective in non-rodents Open
The Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is a central regulator of learning and memory, which poses a problem for targeting it therapeutically. Indeed, our study supports prior conclusions that long-term interference with…
View article: Parametric shift from rational to irrational decisions in mice
Parametric shift from rational to irrational decisions in mice Open
In the classical view of economic choices, subjects make rational decisions evaluating the costs and benefits of options in order to maximize their overall income. Nonetheless, subjects often fail to reach optimal outcomes. The overt value…
View article: Parameter-dependent shift from rational to irrational decisions in mice
Parameter-dependent shift from rational to irrational decisions in mice Open
In the classical view of economic choices, subjects make rational decisions evaluating the costs and benefits of options in order to maximize their overall income. Nonetheless, subjects often fail to reach optimal outcomes. The overt value…
View article: How the Brain Represents Language and Answers Questions? Using an AI System to Understand the Underlying Neurobiological Mechanisms
How the Brain Represents Language and Answers Questions? Using an AI System to Understand the Underlying Neurobiological Mechanisms Open
To understand the computations that underlie high-level cognitive processes we propose a framework of mechanisms that could in principle implement START, an AI program that answers questions using natural language. START organizes a senten…
View article: Improvements in Simultaneous Sodium and Calcium Imaging
Improvements in Simultaneous Sodium and Calcium Imaging Open
High speed imaging of ion concentration changes in neurons is an important and growing tool for neuroscientists. We previously developed a system for simultaneously measuring sodium and calcium changes in small compartments in neurons (Miy…
View article: Temporal coding and rate remapping: Representation of nonspatial information in the hippocampus
Temporal coding and rate remapping: Representation of nonspatial information in the hippocampus Open
Hippocampal place cells represent nonspatial information through a process called rate remapping, which involves a change in the firing rate of a place cell without changes in its spatial specificity. However, many hippocampal phenomena oc…
View article: Serial representation of items during working memory maintenance at letter-selective cortical sites
Serial representation of items during working memory maintenance at letter-selective cortical sites Open
A key component of working memory is the ability to remember multiple items simultaneously. To understand how the human brain maintains multiple items in memory, we examined direct brain recordings of neural oscillations from neurosurgical…
View article: Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta)
Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta) Open
The engram refers to the molecular changes by which a memory is stored in the brain. Substantial evidence suggests that memory involves learning-dependent changes at synapses, a process termed long-term potentiation (LTP). Thus, understand…
View article: Serial representation of items during working memory maintenance at letter-selective cortical sites
Serial representation of items during working memory maintenance at letter-selective cortical sites Open
We used intracranial recordings to study brain oscillations during a working memory task. To analyze sites involved in working memory, we focused on sites at which the elevation of the broadband gamma signal depended on which letter was pr…
View article: Locke's View of the Hard Problem of Consciousness and Its Implications for Neuroscience and Computer Science
Locke's View of the Hard Problem of Consciousness and Its Implications for Neuroscience and Computer Science Open
OPINION article Front. Psychol., 23 June 2017Sec. Perception Science Volume 8 - 2017 | https://doi.org/10.3389/fpsyg.2017.01069
View article: Gradation (approx. 10 size states) of synaptic strength by quantal addition of structural modules
Gradation (approx. 10 size states) of synaptic strength by quantal addition of structural modules Open
Memory storage involves activity-dependent strengthening of synaptic transmission, a process termed long-term potentiation (LTP). The late phase of LTP is thought to encode long-term memory and involves structural processes that enlarge th…
View article: Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions
Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions Open
We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting…
View article: Glutamatergic synapses are structurally and biochemically complex because of multiple plasticity processes: long-term potentiation, long-term depression, short-term potentiation and scaling
Glutamatergic synapses are structurally and biochemically complex because of multiple plasticity processes: long-term potentiation, long-term depression, short-term potentiation and scaling Open
Synapses are complex because they perform multiple functions, including at least six mechanistically different forms of plasticity. Here, I comment on recent developments regarding these processes. (i) Short-term potentiation (STP), a Hebb…
View article: Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells
Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells Open
The computational repertoire of neurons is enhanced by regenerative electrical signals initiated in dendrites. These events, referred to as dendritic spikes, can act as cell-intrinsic amplifiers of synaptic input. Among these signals, dend…
View article: The Role of GluN2C-Containing NMDA Receptors in Ketamine's Psychotogenic Action and in Schizophrenia Models
The Role of GluN2C-Containing NMDA Receptors in Ketamine's Psychotogenic Action and in Schizophrenia Models Open
The NMDA receptor (NMDAR) hypofunction hypothesis of schizophrenia is supported by multiple lines of evidence. Notably, administration of the NMDAR antagonist, ketamine, to healthy human subjects has psychotogenic action, producing both po…