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View article: Proximity-induced rewiring of oncogenic kinase triggers apoptosis
Proximity-induced rewiring of oncogenic kinase triggers apoptosis Open
The active site’s electric field is integral to enzymatic catalysis (e.g., substrate recognition) and nature employs charge-altering post-translational modifications (e.g., phosphorylation) to perturb this electric field and regulate enzym…
View article: A hierarchical analysis of perceived team personality traits in sport
A hierarchical analysis of perceived team personality traits in sport Open
Introduction This study aims to revisit and enhance the foundational concept of perceived team personality by addressing critical conceptual and methodological challenges in previous brand personality studies. While prior studies have iden…
View article: Exploration of the Conditions for Occurrence of Photoplethysmographic Signal Inversion above the Dorsalis Pedis Artery
Exploration of the Conditions for Occurrence of Photoplethysmographic Signal Inversion above the Dorsalis Pedis Artery Open
Inversion of the photoplethysmographic (PPG) signal is a rarely reported case. This signal anomaly can have implications for PPG-based cardiovascular assessments. The conditions for PPG signal inversion in the vicinity of the dorsalis pedi…
View article: Developing technologies to assess vascular ageing: a roadmap from VascAgeNet
Developing technologies to assess vascular ageing: a roadmap from VascAgeNet Open
Vascular ageing (vascular ageing) is the deterioration of arterial structure and function which occurs naturally with age, and which can be accelerated with disease. Measurements of vascular ageing are emerging as markers of cardiovascular…
View article: Editorial: Advances in basic and applied research in photoplethysmography
Editorial: Advances in basic and applied research in photoplethysmography Open
Introducing photoplethysmographyWelcome to this Research Topic in Frontiers in Physiology, focusing on Advances in Basic and Applied Research in Photoplethysmography.Photoplethysmography (PPG) is a low-cost and simple vascular optics techn…
View article: Introduction of electromechanical projects within a Mechanical Engineering Technology Capstone Program
Introduction of electromechanical projects within a Mechanical Engineering Technology Capstone Program Open
Engineering technology capstone experiences are intended to develop student competencies in applying technical and non-technical skill sets.To further this objective, electromechanical projects were introduced within the University of Main…
View article: The effect of lower limb strengthening exercise on orthostatic blood pressure and the skeletal muscle pump in older people with orthostatic hypotension
The effect of lower limb strengthening exercise on orthostatic blood pressure and the skeletal muscle pump in older people with orthostatic hypotension Open
Introduction Activation of muscles during standing is recommended to activate the skeletal muscle pump, increasing venous return and increasing blood pressure (BP) in people with orthostatic hypotension (OH). Aim The aim of this study is t…
View article: Deep learning classification of systemic sclerosis from multi-site photoplethysmography signals
Deep learning classification of systemic sclerosis from multi-site photoplethysmography signals Open
Introduction: A pilot study assessing a novel approach to identify patients with Systemic Sclerosis (SSc) using deep learning analysis of multi-site photoplethysmography (PPG) waveforms (“DL-PPG”). Methods: PPG recordings having baseline, …
View article: The 2023 wearable photoplethysmography roadmap
The 2023 wearable photoplethysmography roadmap Open
Photoplethysmography is a key sensing technology which is used in wearable devices such as smartwatches and fitness trackers. Currently, photoplethysmography sensors are used to monitor physiological parameters including heart rate and hea…
View article: Deep learning identification of coronary artery disease from bilateral finger photoplethysmography sensing: A proof-of-concept study
Deep learning identification of coronary artery disease from bilateral finger photoplethysmography sensing: A proof-of-concept study Open
Background: A proof-of-concept study assessing a novel approach to identify patients with coronary artery disease (CAD) using deep learning analysis of bilateral-site photoplethysmography (PPG) waveforms (“DL-PPG”).Methodology: DL-PPG was …
View article: Usability and Preliminary Efficacy of an Artificial Intelligence–Driven Platform Supporting Dietary Management in Diabetes: Mixed Methods Study
Usability and Preliminary Efficacy of an Artificial Intelligence–Driven Platform Supporting Dietary Management in Diabetes: Mixed Methods Study Open
Background Nutrition plays an important role in diabetes self-management. Web-based diabetes care, driven by artificial intelligence (AI), enables more personalized care. Objective This study aimed to examine the usability and preliminary …
View article: Supplementary Figure 5 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 5 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 1.3MB, Growth of xenografts, where the hosts were treated i.p. with 75 mg/kg ABT-737 or vehicle daily from 7 days post-engraftment for 21 days, 10 mice/group.
View article: Supplementary Figure 7 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 7 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 7.8MB, Effects of ABT-737 on growth of 3D melanoma spheroids derived from C8161/NOXA clone C6 (A) ABT-737 was applied at the concentrations shown for 3 days. Note the dose-dependent inhibition of proliferation and invasion as we…
View article: Data from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Data from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
Purpose: Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Inhibiting antiapoptotic BCL-2 and its relatives is an attractive strategy for sensitizing lymphoid malignancies to drugs but it has been largel…
View article: Supplementary Figure 6 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 6 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 85K, Maintenance of NOXA levels in ABT-737 treated xenografts.
View article: Supplementary Figure 6 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 6 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 85K, Maintenance of NOXA levels in ABT-737 treated xenografts.
View article: Supplementary Figure 3 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 3 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 3.7MB, Spheroids derived from untransfected or NOXA-overexpressing MM200 or C8161 melanoma cells.
View article: Supplementary Figure 4 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 4 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 1.6MB, Sensitization of MM200 and Me4405 cells in 2D culture to ABT-737 by flavopiridol.
View article: Supplementary Figure 4 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 4 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 1.6MB, Sensitization of MM200 and Me4405 cells in 2D culture to ABT-737 by flavopiridol.
View article: Supplementary Figure 3 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 3 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 3.7MB, Spheroids derived from untransfected or NOXA-overexpressing MM200 or C8161 melanoma cells.
View article: Data from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Data from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
Purpose: Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Inhibiting antiapoptotic BCL-2 and its relatives is an attractive strategy for sensitizing lymphoid malignancies to drugs but it has been largel…
View article: Supplementary Figure 7 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 7 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 7.8MB, Effects of ABT-737 on growth of 3D melanoma spheroids derived from C8161/NOXA clone C6 (A) ABT-737 was applied at the concentrations shown for 3 days. Note the dose-dependent inhibition of proliferation and invasion as we…
View article: Supplementary Table 1 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Table 1 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 46K, Sensitivity of NOXA-transduced melanoma cells to DNA-damaging agents.
View article: Supplementary Figure 2 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 2 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 75K, Expanded immunoblot analysis.
View article: Supplementary Figure 1 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 1 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 2.3MB, Growth of NOXA-transduced melanoma cell lines in the presence or absence of serum.
View article: Supplementary Figure 1 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 1 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 2.3MB, Growth of NOXA-transduced melanoma cell lines in the presence or absence of serum.
View article: Supplementary Table 2 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Table 2 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 75K, ffects of NOXA knockdown on sensitization to ABT-737 by flavopiridol.
View article: Supplementary Figure 2 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737
Supplementary Figure 2 from Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737 Open
PDF file - 75K, Expanded immunoblot analysis.