John A. Lucas
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View article: NDT Magnetic Techniques Applied to Degradation Measurement on Rolling Mill Rolls
NDT Magnetic Techniques Applied to Degradation Measurement on Rolling Mill Rolls Open
View article: Reliability of remote self-administered web-based digital cognitive measures and comparison to in-person neuropsychological tests: Stricker Learning Span, Symbols Test and the Mayo Test Drive Screening Battery Composite
Reliability of remote self-administered web-based digital cognitive measures and comparison to in-person neuropsychological tests: Stricker Learning Span, Symbols Test and the Mayo Test Drive Screening Battery Composite Open
Structured Abstract INTRODUCTION We describe the reliability of remote self-administered digital cognitive measures completed via the Mayo Test Drive (MTD) web-based platform. METHODS 1,846 participants (mean age=70, SD=12, range 31-101; 4…
View article: Novel set of plasma proteins classifies Alzheimer's dementia in African American individuals with high accuracy
Novel set of plasma proteins classifies Alzheimer's dementia in African American individuals with high accuracy Open
INTRODUCTION African American (AA) individuals are underrepresented in biomarker studies for Alzheimer's disease (AD). Biomarkers that reflect the heterogeneity of AD and achieve the greatest accuracy across populations are sorely needed. …
View article: Mayo Normative Studies: Regression-based normative data for remote self-administration of the Stricker Learning Span, Symbols Test, and Mayo Test Drive Screening Battery Composite and validation in individuals with mild cognitive impairment and dementia
Mayo Normative Studies: Regression-based normative data for remote self-administration of the Stricker Learning Span, Symbols Test, and Mayo Test Drive Screening Battery Composite and validation in individuals with mild cognitive impairment and dementia Open
Objective: Few normative data for unsupervised, remotely-administered computerized cognitive measures are available. We examined variables to include in normative models for Mayo Test Drive (MTD, a multi-device remote cognitive asse…
View article: Reliability of the remote digital self‐administered Stricker Learning Span, Symbols Test and Mayo Test DRIVE Screening Battery Composite
Reliability of the remote digital self‐administered Stricker Learning Span, Symbols Test and Mayo Test DRIVE Screening Battery Composite Open
Background Mayo Test DRIVE (MTD): Test D evelopment through R apid I teration, V alidation and E xpansion, is a web‐based multi‐device (smartphone, tablet, personal computer) platform optimized for remote self‐administered cognitive assess…
View article: Mayo Normative Studies: regression‐based normative data for remote self‐administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite for ages 33‐100 and validation in MCI and dementia
Mayo Normative Studies: regression‐based normative data for remote self‐administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite for ages 33‐100 and validation in MCI and dementia Open
Background Few normative data for computerized measures administered in unsupervised remote environments are available. We aimed to determine what variables to include in normative models for remote self‐administered assessments, develop n…
View article: Mayo Normative Studies: regression‐based normative data for remote self‐administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite for ages 33‐100 and validation in MCI and dementia
Mayo Normative Studies: regression‐based normative data for remote self‐administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite for ages 33‐100 and validation in MCI and dementia Open
Background Few normative data for computerized measures administered in unsupervised remote environments are available. We aimed to determine what variables to include in normative models for remote self‐administered assessments, develop n…
View article: Untargeted plasma proteomics nominates a novel set of plasma biomarkers for Alzheimer’s disease in African Americans
Untargeted plasma proteomics nominates a novel set of plasma biomarkers for Alzheimer’s disease in African Americans Open
Background Plasma biomarker development is of increasing interest due to improved accessibility compared to established diagnostic modalities for Alzheimer’s disease (AD). However, current plasma biomarker candidates have not been tested c…
View article: Association among Cognitive Stress Appraisal, Chronic Stress, and Cognition in Cognitively Normal Older Adults: Preliminary Findings
Association among Cognitive Stress Appraisal, Chronic Stress, and Cognition in Cognitively Normal Older Adults: Preliminary Findings Open
Background Characterizing stress can inform our understanding of direct and indirect pathways impacting mental and physical health outcomes, including age‐related cognitive decline. Chronic stress has been strongly associated with increase…
View article: Mayo Normative Studies: regression-based normative data for remote self-administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite and validation in individuals with Mild Cognitive Impairment and dementia
Mayo Normative Studies: regression-based normative data for remote self-administration of the Stricker Learning Span, Symbols Test and Mayo Test Drive Screening Battery Composite and validation in individuals with Mild Cognitive Impairment and dementia Open
Objective Few normative data for unsupervised, remotely-administered computerized cognitive measures are available. We examined variables to include in normative models for Mayo Test Drive (a multi-device remote cognitive assessment platfo…
View article: Disparate Dementia Risk Factors Are Associated with Cognitive Impairment and Rates of Decline in African Americans
Disparate Dementia Risk Factors Are Associated with Cognitive Impairment and Rates of Decline in African Americans Open
Objective This study was undertaken to evaluate the frequency of modifiable dementia risk factors and their association with cognitive impairment and rate of decline in diverse participants engaged in studies of memory and aging. Methods M…
View article: Depression is associated with dementia and accelerated cognitive decline in African Americans
Depression is associated with dementia and accelerated cognitive decline in African Americans Open
Background African Americans (AA) represent 12% of the United States population ≥65 years‐old, but 19% of persons with dementia. Inequalities in social determinants of health may influence access to healthcare resources contributing to inc…
View article: Age‐specific Barriers and Facilitators to Research Participation Among Underrepresented African Americans
Age‐specific Barriers and Facilitators to Research Participation Among Underrepresented African Americans Open
Background African Americans experience a high dementia burden yet are critically underrepresented in observational studies and clinical trials in memory and aging. Lack of adequate representation increases the likelihood that research fin…
View article: Plasma biomarkers of Alzheimer’s disease in a biracial, community‐based sample
Plasma biomarkers of Alzheimer’s disease in a biracial, community‐based sample Open
Background For blood‐based biomarkers to fulfill their potential to revolutionize diagnosis and management of Alzheimer’s disease (AD), additional research in diverse populations remains critical. Here, we analyzed a biracial sample to ass…
View article: Targeted plasma eQTL and pQTL to identify potential novel biomarkers for Alzheimer’s Disease in African Americans
Targeted plasma eQTL and pQTL to identify potential novel biomarkers for Alzheimer’s Disease in African Americans Open
Background Given the overlap of symptoms between Alzheimer’s disease (AD) and other dementias, it is essential to develop widely accessible biomarkers that will ensure an accurate diagnosis of AD to enable its proper treatment. African Ame…
View article: Time Until Proof of Credentials Significantly Decreases With the Use of Blockchain Technology and the Document Management System
Time Until Proof of Credentials Significantly Decreases With the Use of Blockchain Technology and the Document Management System Open
View article: Association of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort
Association of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort Open
In a biracial community-based sample of adults, we observed that sex differences, CKD, and vascular risk factors, but not self-reported race, contributed to variation in plasma AD biomarkers. Although some prior studies have reported prima…
View article: Effect of chain length on the pyrolysis of perfluorocarboxylic acids
Effect of chain length on the pyrolysis of perfluorocarboxylic acids Open
Per- and polyfluoroalkyl substance (PFAS) are increasingly becoming the contamination issue of our time, due to their environmental persistence, bioaccumulation and mounting evidence of their toxicity. Herein we examined the pyrolytic deco…
View article: CTNI-31. COG ACNS1721: PHASE 2 STUDY OF VELIPARIB AND LOCAL IRRADIATION, FOLLOWED BY MAINTENANCE VELIPARIB AND TEMOZOLOMIDE, IN PATIENTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMA WITHOUT H3 K27M OR BRAF MUTATIONS
CTNI-31. COG ACNS1721: PHASE 2 STUDY OF VELIPARIB AND LOCAL IRRADIATION, FOLLOWED BY MAINTENANCE VELIPARIB AND TEMOZOLOMIDE, IN PATIENTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMA WITHOUT H3 K27M OR BRAF MUTATIONS Open
BACKGROUND The outcome for pediatric patients with high-grade glioma (HGG) remains poor. Veliparib, a potent oral PARP1/2 inhibitor, enhances the activity of radiotherapy and DNA-damaging chemotherapy. Preclinical data indicates that velip…
View article: Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old
Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old Open
Background: Dementia, vascular disease, and cancer increase with age, enabling complex comorbid interactions. Understanding vascular and cancer contributions to dementia risk and neuropathology in oldest-old may improve risk modification a…
View article: Transcript levels in plasma contribute substantial predictive value as potential Alzheimer's disease biomarkers in African Americans
Transcript levels in plasma contribute substantial predictive value as potential Alzheimer's disease biomarkers in African Americans Open
View article: A Review of Engine Performance and Emissions Using Single and Dual Biodiesel Fuels: Research Paths, Challenges, Motivations and Recommendations
A Review of Engine Performance and Emissions Using Single and Dual Biodiesel Fuels: Research Paths, Challenges, Motivations and Recommendations Open
View article: Cytological aspects of compatible and incompatible interactions between cashew (Anacardium occidentale L.) seedlings and isolates of Colletotrichum gloeosporioides (Penz.) complex
Cytological aspects of compatible and incompatible interactions between cashew (Anacardium occidentale L.) seedlings and isolates of Colletotrichum gloeosporioides (Penz.) complex Open
A strategy in the control anthracnose of cashew (Anacardium occidentale L.) is the management of crop phenology and defense mechanisms of this host. In previous studies, under controlled conditions, the seedling reactions of 5 cashew clone…
View article: Dementia friendly community outreach improves research participation and dementia resource utilization among African Americans
Dementia friendly community outreach improves research participation and dementia resource utilization among African Americans Open
Background African Americans are at greater risk of Alzheimer’s disease (AD) and AD‐related dementia (ADRD). They are also less likely to access dementia resources or participate in dementia research. The National Alzheimer’s Project Act (…
View article: Epidemiological Studies of Pan-Azole Resistant Aspergillus fumigatus Populations Sampled during Tulip Cultivation Show Clonal Expansion with Acquisition of Multi-Fungicide Resistance as Potential Driver
Epidemiological Studies of Pan-Azole Resistant Aspergillus fumigatus Populations Sampled during Tulip Cultivation Show Clonal Expansion with Acquisition of Multi-Fungicide Resistance as Potential Driver Open
Pan-azole resistant isolates are found in clinical and environmental Aspergillus fumigatus (Af) populations. Azole resistance can evolve in both settings, with Af directly targeted by antifungals in patients and, in the environment, Af uni…
View article: ARMADA: Assessing reliable measurement in Alzheimer’s disease and cognitive aging project methods
ARMADA: Assessing reliable measurement in Alzheimer’s disease and cognitive aging project methods Open
Introduction Early detection of cognitive decline in older adults is a public health priority. Advancing Reliable Measurement in Alzheimer's Disease and Cognitive Aging (ARMADA), a multisite study, is validating cognition, emotion, motor, …
View article: Testing an Alzheimer’s Disease Educational Approach in Two African American Neighborhoods in Florida
Testing an Alzheimer’s Disease Educational Approach in Two African American Neighborhoods in Florida Open
View article: Understanding the role of cultural factors in the risk of mild cognitive impairment in diverse populations
Understanding the role of cultural factors in the risk of mild cognitive impairment in diverse populations Open
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View article: Transcript Levels in Plasma Contribute Substantial Predictive Value as Potential Alzheimer's Disease Biomarkers in African Americans
Transcript Levels in Plasma Contribute Substantial Predictive Value as Potential Alzheimer's Disease Biomarkers in African Americans Open
View article: Cytological aspects of compatible and incompatible interactions between cashew (Anacardium occidentale L.) seedlings and isolates of Colletotrichum gloeosporioides (Penz.) complex
Cytological aspects of compatible and incompatible interactions between cashew (Anacardium occidentale L.) seedlings and isolates of Colletotrichum gloeosporioides (Penz.) complex Open
A strategy in the control anthracnose of cashew (Anacardium occidentale L.) is the management of crop phenology and defense mechanisms of this host. In previous studies, under controlled conditions, the seedling reactions of 5 cashew clone…