John E. Lunn
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View article: Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance
Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance Open
Candidozyma auris is an emerging multidrug-resistant fungal pathogen that poses a major public-health challenge owing to high mortality and the limited efficacy of current therapies. Echinocandins, which inhibit β-glucan synthesis, are fir…
View article: The sucrose–trehalose 6-phosphate nexus is conserved in flowering plants with different phloem loading and carbon storage strategies
The sucrose–trehalose 6-phosphate nexus is conserved in flowering plants with different phloem loading and carbon storage strategies Open
Trehalose 6-phosphate (Tre6P) is a signalling metabolite that maintains sucrose homeostasis and links plant growth and development to the availability of sucrose. Most of our knowledge of the nexus between Tre6P and sucrose comes from stud…
View article: TPS Proteins coordinate plant growth with sugar availability via the SnRK1 Kinase
TPS Proteins coordinate plant growth with sugar availability via the SnRK1 Kinase Open
The ability to sense and respond to nutrients determines adaptation and survival in all organisms. In plants, sucrose stimulates growth and developmental progression via the signalling sugar trehalose 6-phosphate (T6P) which reflects sucro…
View article: Exploring the diversity of the CO<sub>2</sub>-concentrating mechanism (CCM) in different C<sub>4</sub> subtypes
Exploring the diversity of the CO<sub>2</sub>-concentrating mechanism (CCM) in different C<sub>4</sub> subtypes Open
C 4 plants have traditionally been classified into NADP-malic enzyme (NADP-ME), NAD-malic enzyme (NAD-ME) and PEP carboxykinase (PEPCK) subtypes based on the predominant C 4 -acid decarboxylating enzyme. To investigate the relative contrib…
View article: Overcoming extensive redundancy in the arabidopsis <i>TREHALOSE-6-PHOSPHATE PHOSPHATASE</i> gene family reveals connections to development and iron homeostasis
Overcoming extensive redundancy in the arabidopsis <i>TREHALOSE-6-PHOSPHATE PHOSPHATASE</i> gene family reveals connections to development and iron homeostasis Open
Arabidopsis encodes ten TREHALOSE-6-PHOSPHATE PHOSPHATASE ( TPP ) genes, homologous to maize RAMOSA3 (I), which controls shoot branching. To explore the roles of the arabidopsis TPPs , we analyzed their expression in shoot apices and found…
View article: Intercellular compartmentation of trehalose 6-phosphate metabolism in <i>Setaria viridis</i> leaves
Intercellular compartmentation of trehalose 6-phosphate metabolism in <i>Setaria viridis</i> leaves Open
Trehalose 6-phosphate (Tre6P) is a signal metabolite that links carbon metabolism with plant development. Our current understanding of Tre6P metabolism and signalling is predominantly based on studies in Arabidopsis thaliana. Some features…
View article: Seasonal changes in the physiology and metabolism of grapevine perennating buds
Seasonal changes in the physiology and metabolism of grapevine perennating buds Open
Grapevine ( Vitis vinifera L. ) buds undergo seasonal dormancy to survive unfavourable conditions and synchronize growth with environmental cues. While dormancy transitions have been widely studied in temperate woody perennials, the physio…
View article: Plastidial starch phosphorylase regulates maltodextrin turnover during starch granule initiation in Arabidopsis leaves
Plastidial starch phosphorylase regulates maltodextrin turnover during starch granule initiation in Arabidopsis leaves Open
PLASTIDIAL STARCH PHOSPHORYLASE 1 (PHS1) is considered integral to starch synthesis, yet its role in transient starch synthesis in photosynthetic tissues remains unclear, as mutation of PHS1 in Arabidopsis (Arabidopsis thaliana) does not a…
View article: Accumulation of Trehalose-6-Phosphate in Candida auris results in Decreased Echinocandin Resistance and Tolerance by Affecting Cell Wall Chitin Synthesis
Accumulation of Trehalose-6-Phosphate in Candida auris results in Decreased Echinocandin Resistance and Tolerance by Affecting Cell Wall Chitin Synthesis Open
The rise of multidrug-resistant fungal pathogens, like Candida auris, poses a significant public health challenge due to high mortality rates and the limited effectiveness of current treatment options. Echinocandins, targeting β-glucan syn…
View article: Too much sugar makes plants ‘pregnant’: maternal sucrose signals fertilization in Arabidopsis seeds
Too much sugar makes plants ‘pregnant’: maternal sucrose signals fertilization in Arabidopsis seeds Open
Reproduction is deemed successful if it ensures the perpetuation of the species. Nonetheless, evolution has optimized reproductive efficiency across a diverse range of strategies. Animal vivipary, the process in which embryos develop insid…
View article: The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i>
The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i> Open
The incidence of non- albicans Candida infections has witnessed a substantial rise in recent decades. Candida glabrata (Nakaseomyces glabratus ), an opportunistic human fungal pathogen, is accountable for both superficial mucosal and life-…
View article: Integrated analysis of metabolites and enzyme activities reveals the plasticity of central carbon metabolism in grape (<i>Vitis vinifera</i> cv. Cabernet Sauvignon) berries under carbon limitation
Integrated analysis of metabolites and enzyme activities reveals the plasticity of central carbon metabolism in grape (<i>Vitis vinifera</i> cv. Cabernet Sauvignon) berries under carbon limitation Open
High temperatures increase the sugar concentration of grape (Vitis vinifera L.) berries, which can negatively affect the composition and quality of wine, and global climate change is expected to exacerbate this problem. Modifying the sourc…
View article: Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in <i>Arabidopsis</i>
Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in <i>Arabidopsis</i> Open
In plants, development of all above-ground tissues relies on the shoot apical meristem (SAM) which balances cell proliferation and differentiation to allow life-long growth. To maximize fitness and survival, meristem activity is adjusted t…
View article: Strigolactone signalling inhibits trehalose 6‐phosphate signalling independently of <scp>BRC1</scp> to suppress shoot branching
Strigolactone signalling inhibits trehalose 6‐phosphate signalling independently of <span>BRC1</span> to suppress shoot branching Open
Summary The phytohormone strigolactone (SL) inhibits shoot branching, whereas the signalling metabolite trehalose 6‐phosphate (Tre6P) promotes branching. How Tre6P and SL signalling may interact and which molecular mechanisms might be invo…
View article: Intercellular compartmentation of trehalose 6-phosphate metabolism in <i>Setaria viridis</i> leaves
Intercellular compartmentation of trehalose 6-phosphate metabolism in <i>Setaria viridis</i> leaves Open
Trehalose 6-phosphate (Tre6P) is a signal metabolite that links carbon metabolism with plant development. Our current understanding of Tre6P metabolism and signalling is predominantly based on studies in Arabidopsis thaliana . Some feature…
View article: The stress-protectant molecule trehalose mediates fluconazole tolerance in<i>Candida glabrata</i>
The stress-protectant molecule trehalose mediates fluconazole tolerance in<i>Candida glabrata</i> Open
The incidence of non- albicans Candida infections has witnessed a substantial rise in recent decades. Candida glabrata (Nakaseomyces glabratus) , an opportunistic human fungal pathogen, is accountable for both superficial mucosal and life-…
View article: Guidelines for designing and interpreting drought experiments in controlled conditions
Guidelines for designing and interpreting drought experiments in controlled conditions Open
International audience
View article: Spliceosomal complex components are critical for adjusting the C:N balance during high‐light acclimation
Spliceosomal complex components are critical for adjusting the C:N balance during high‐light acclimation Open
SUMMARY Plant acclimation to an ever‐changing environment is decisive for growth, reproduction, and survival. Light availability limits biomass production on both ends of the intensity spectrum. Therefore, the adjustment of plant metabolis…
View article: Direct and indirect responses of the Arabidopsis transcriptome to an induced increase in trehalose 6-phosphate
Direct and indirect responses of the Arabidopsis transcriptome to an induced increase in trehalose 6-phosphate Open
Trehalose 6-phosphate (Tre6P) is an essential signal metabolite that regulates the level of sucrose, linking growth and development to the metabolic status. We hypothesized that Tre6P plays a role in mediating the regulation of gene expres…
View article: S <sub>1</sub> basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs
S <sub>1</sub> basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs Open
Plants tightly control growth of their lateral organs, which led to the concept of apical dominance. However, outgrowth of the dormant lateral primordia is sensitive to the plant’s nutritional status, resulting in an immense plasticity in …
View article: The trehalose 6‐phosphate phosphatase family in plants
The trehalose 6‐phosphate phosphatase family in plants Open
Trehalose 6‐phosphate (Tre6P), the intermediate of trehalose biosynthesis, is an essential signalling metabolite linking plant growth and development to carbon metabolism. While recent work has focused predominantly on the enzymes that pro…
View article: Direct and indirect responses of the Arabidopsis transcriptome to an induced increase in trehalose 6-phosphate
Direct and indirect responses of the Arabidopsis transcriptome to an induced increase in trehalose 6-phosphate Open
Trehalose 6-phosphate (Tre6P) is an essential signal metabolite that reports and regulates the level of sucrose, linking growth and development to the metabolic status. We hypothesized that Tre6P plays a role in mediating the regulation of…
View article: Spliceosomal complex components are critical for adjusting the C:N balance during high-light acclimation
Spliceosomal complex components are critical for adjusting the C:N balance during high-light acclimation Open
Plant acclimation to an ever-changing environment is decisive for growth, reproduction and survival. Light availability limits biomass production on both ends of the intensity spectrum. Therefore, the adjustment of plant metabolism is cent…
View article: S<sub>1</sub>basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs
S<sub>1</sub>basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs Open
Plants exhibit an immense plasticity in their architecture. While the impact of hormonal regulation is well-characterised, the importance of sugar-signalling has just recently emerged. Here, we addressed which sugar-signalling components m…
View article: The transcription factor bZIP11 acts antagonistically with trehalose 6-phosphate to inhibit shoot branching
The transcription factor bZIP11 acts antagonistically with trehalose 6-phosphate to inhibit shoot branching Open
The ontogenetic regulation of shoot branching allows plants to adjust their architecture in accordance with the environment. This process is due to the regulation of axillary bud outgrowth into branches, which can be induced by increasing …