John M. Davis
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View article: Non-invasive brain stimulation augmentation therapy for treatment-resistant schizophrenia: a systematic review and network meta-analysis
Non-invasive brain stimulation augmentation therapy for treatment-resistant schizophrenia: a systematic review and network meta-analysis Open
German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung/BMBF; 01KG2206).
View article: Sex differences in the efficacy and tolerability of antipsychotic drugs in people with an acute exacerbation of schizophrenia: protocol for an individual-participant-data, dose-response, network meta-analysis
Sex differences in the efficacy and tolerability of antipsychotic drugs in people with an acute exacerbation of schizophrenia: protocol for an individual-participant-data, dose-response, network meta-analysis Open
Background There are currently no sex-specific recommendations for antipsychotic prescribing in schizophrenia, although women may be more susceptible to certain side-effects and may require lower doses to achieve comparable efficacy to me…
View article: Feature-Level Insights into the Progesterone–Estradiol Ratio in Postmenopausal Women Using Explainable Machine Learning
Feature-Level Insights into the Progesterone–Estradiol Ratio in Postmenopausal Women Using Explainable Machine Learning Open
The protective role of progesterone against estradiol-driven proliferation is essential for preserving endometrial homeostasis. However, the factors that influence the progesterone–estradiol (P4:E2) ratio remain poorly characterized. This …
View article: Oxytocin, Vasopressin and Stress: A Hormetic Perspective
Oxytocin, Vasopressin and Stress: A Hormetic Perspective Open
The purpose of this article is to examine a previously unrecognized role for the vasopressin–oxytocin (VP-OT) system in mammalian “stress-response hormesis.” The current review adds hormesis to the long list of beneficial effects of OT. Ho…
View article: Feature-Level Insights into the Progesterone-Estradiol Ratio Using Explainable Machine Learning in Postmenopausal Women
Feature-Level Insights into the Progesterone-Estradiol Ratio Using Explainable Machine Learning in Postmenopausal Women Open
The protective role of progesterone (P4) against estradiol (E2)-driven proliferation is essential for preserving endometrial homeostasis. However, the factors that influence the P4:E2 ratio remain poorly characterized. This study aimed to …
View article: Negative Impact of Olanzapine on ICU Delirium Resolution: An Emulated Clinical Trial
Negative Impact of Olanzapine on ICU Delirium Resolution: An Emulated Clinical Trial Open
Introduction: Delirium is a common and debilitating clinical complication among ICU patients. Despite the prevalence of this condition, there are insufficient data to support or refute the routine use of atypical antipsychotics since the e…
View article: Enhancing mental health care: a problem, resources and goals oriented multidimensional framework (PRoGO)
Enhancing mental health care: a problem, resources and goals oriented multidimensional framework (PRoGO) Open
Background Lawrence Weed introduced the “Problem-Oriented Medical Records” (POMR) approach to medicine. Its core principle is that treatment should be organised around patients’ specific problems. This approach gained widespread adoption i…
View article: Evidence for ApoE receptor 2-Disabled homolog-1 pathway disruption in the amygdala in sporadic Alzheimer’s disease
Evidence for ApoE receptor 2-Disabled homolog-1 pathway disruption in the amygdala in sporadic Alzheimer’s disease Open
INTRODUCTION The ApoE receptor 2-Disabled homolog-1 (ApoER2-Dab1) pathway suppresses Tau phosphorylation as part of a multi-arm pathway that regulates cytoskeletal and synaptic integrity. We previously showed that multiple ApoER2-Dab1 path…
View article: L-Theanine Amino Acid Thermo-Oxidative Degradation Kinetics in Low pH Formulations for Shelf-Life Prediction Using the Arrhenius Equation
L-Theanine Amino Acid Thermo-Oxidative Degradation Kinetics in Low pH Formulations for Shelf-Life Prediction Using the Arrhenius Equation Open
The amino acid L-theanine is frequently used in dietary supplements and nutraceutical foods and beverages for its ability to modulate brain activity and neurotransmitter levels. The instability of this compound in acidic formulations (pH 2…
View article: Negative Impact of Olanzapine on ICU Delirium Resolution: A Real-World Data Study
Negative Impact of Olanzapine on ICU Delirium Resolution: A Real-World Data Study Open
Introduction: Delirium is a common and debilitating clinical complication among ICU patients. Despite its prevalence, there are insufficient data to support or refute the routine use of atypical antipsychotics since the existing evidence r…
View article: Cognitive changes in schizophrenia before and after illness onset: A meta-analysis examining consistency in measurement tools as a moderator
Cognitive changes in schizophrenia before and after illness onset: A meta-analysis examining consistency in measurement tools as a moderator Open
View article: Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part II
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part II Open
Purpose/Background This is the second part of a 2-part article that proposes improving the United States (US) clozapine package insert. Part II focuses on fatal outcomes and the 5 boxed warnings, 4 specifically for clozapine: severe neutro…
View article: Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I Open
Purpose/Background Clozapine was approved in the United States (US) using 1989 regulations and knowledge. After 30 years, many sections of the US package insert (PI) are outdated. Methods We comprehensively reviewed the literature to propo…
View article: Theoretical framework for chip-scale wavefront shaping with transverse spatial mode modulation
Theoretical framework for chip-scale wavefront shaping with transverse spatial mode modulation Open
Visible-wavelength applications such as quantum information systems, portable displays, and biological sensing and imaging devices require compact wavefront shaping capabilities. However, current chip-scale methods based on optical phased …
View article: COSMIN systematic review and meta-analysis of the measurement properties of the Positive and Negative Syndrome Scale (PANSS)
COSMIN systematic review and meta-analysis of the measurement properties of the Positive and Negative Syndrome Scale (PANSS) Open
There was no specific funding source for this research.
View article: COSMIN review of the PANSS Marder factor solution and other factor models in people with schizophrenia
COSMIN review of the PANSS Marder factor solution and other factor models in people with schizophrenia Open
The Positive and Negative Syndrome Scale (PANSS) is widely used to assess schizophrenia symptoms. Initially designed with three subscales, Marder et al.´s 5-factor-Model (M5M) first proposed in 1997 has been frequently used in treatment tr…
View article: The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia
The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia Open
German Federal Ministry of Education and Research.
View article: COSMIN systematic review and meta-analysis of the measurement properties of the PANSS-6
COSMIN systematic review and meta-analysis of the measurement properties of the PANSS-6 Open
The Positive and Negative Syndrome Scale (PANSS-30) is the standard instrument for assessing symptoms of schizophrenia and related psychotic disorders. However, its long administration time and structural issues have prompted the developme…
View article: Efficacy of clozapine versus second-generation antipsychotics in people with treatment-resistant schizophrenia: a systematic review and individual patient data meta-analysis
Efficacy of clozapine versus second-generation antipsychotics in people with treatment-resistant schizophrenia: a systematic review and individual patient data meta-analysis Open
View article: BLUNTED CORTISOL RESPONSE TO ACUTE PSYCHOSOCIAL STRESS IN WOMEN WITH PREMENSTRUAL DYSPHORIC DISORDER
BLUNTED CORTISOL RESPONSE TO ACUTE PSYCHOSOCIAL STRESS IN WOMEN WITH PREMENSTRUAL DYSPHORIC DISORDER Open
Background Despite being considered a stress-related condition, it is not known whether the hypothalamic-pituitary-adrenal (HPA) axis is dysfunctional in response to acute psychosocial stress in Premenstrual Dysphoric Disorder (PMDD). This…
View article: Formal and functional factors in classifier choice: Evidence from American Sign Language and Danish Sign Language
Formal and functional factors in classifier choice: Evidence from American Sign Language and Danish Sign Language Open
Traditionally so-called classifiers in productively formed verbs of motion and location in sign languages are said to reflect the semantic class of the moving or located entity. The verbs can include one of several different classifiers ab…
View article: Clinician-Reported Negative Symptom Scales: A Systematic Review of Measurement Properties
Clinician-Reported Negative Symptom Scales: A Systematic Review of Measurement Properties Open
Background Negative symptoms of schizophrenia are correlated with reduction of normal function and lower quality of life. They were newly defined by the NIMH-MATRICS Consensus in 2005, dividing the rating tools to assess them into first-ge…
View article: 7458 Eight Weeks Intranasal Oxytocin vs. Placebo Does Not Impact Circulating Oxytocin or Arginine-Vasopressin Levels in Adults With Obesity
7458 Eight Weeks Intranasal Oxytocin vs. Placebo Does Not Impact Circulating Oxytocin or Arginine-Vasopressin Levels in Adults With Obesity Open
Disclosure: A. Aulinas: None. F. Galbiati: None. M. Wronski: None. C.S. Carter: None. J. Davis: None. H.P. Nazarloo: None. K. Holman: None. G. Julia: None. E. Asanza: None. S.E. Smith: None. L. Kerem: None. F. Plessow: None. E.A. Lawson: R…
View article: Relationship of cognitive measures to mRNA levels in lymphocytes from patients with schizophrenia and controls
Relationship of cognitive measures to mRNA levels in lymphocytes from patients with schizophrenia and controls Open
View article: Peripheral Blood Mononuclear Cell Expression of Cation-Chloride Cotransporter (CCC) Genes in Premenstrual Dysphoric Disorder (PMDD) across the Menstrual Cycle—A Preliminary Study
Peripheral Blood Mononuclear Cell Expression of Cation-Chloride Cotransporter (CCC) Genes in Premenstrual Dysphoric Disorder (PMDD) across the Menstrual Cycle—A Preliminary Study Open
Premenstrual Dysphoric Disorder (PMDD) is a psychiatric condition characterized by debilitating affective symptomatology in the luteal phase of the menstrual cycle. Based on the previous reports that PMDD may be related to GABAergic cellul…
View article: Positive association between dehydroepiandrosterone (DHEA) and gene expression of the gamma-aminobutyric acid (GABA-A) receptor δ subunit
Positive association between dehydroepiandrosterone (DHEA) and gene expression of the gamma-aminobutyric acid (GABA-A) receptor δ subunit Open
Gamma-aminobutyric acid A (GABA-A) receptors in the cells of the immune system enhance anti-inflammatory responses by regulating cytokine secretion, cytotoxic responses, and cell activation. In the CNS, the formation of GABA-A subunits int…
View article: Visuospatial Function in Women with Premenstrual Dysphoric Disorder
Visuospatial Function in Women with Premenstrual Dysphoric Disorder Open
Background/Objectives: Premenstrual dysphoric disorder (PMDD) is an understudied psychiatric condition affecting reproductive-age women who experience negative mood in the luteal phase of the menstrual cycle. Cognitive functions in PMDD ar…
View article: Efficacy, acceptability and side-effects of oral versus long-acting- injectables antipsychotics: Systematic review and network meta-analysis
Efficacy, acceptability and side-effects of oral versus long-acting- injectables antipsychotics: Systematic review and network meta-analysis Open
Long-acting injectable antipsychotics (LAIs) are primarily used for relapse prevention, but in some settings and situations, they may also be useful for acute treatment of schizophrenia. We conducted a systematic review and frequentist net…
View article: Blunted Cortisol Response to Acute Psychosocial Stress in Women With Premenstrual Dysphoric Disorder
Blunted Cortisol Response to Acute Psychosocial Stress in Women With Premenstrual Dysphoric Disorder Open
Background Despite being considered a stress-related condition, it is not known whether the hypothalamic-pituitary-adrenal (HPA) axis is dysfunctional in response to acute psychosocial stress in premenstrual dysphoric disorder (PMDD). This…
View article: Are the results of open randomised controlled trials comparing antipsychotic drugs in schizophrenia biased? Exploratory meta- and subgroup analysis
Are the results of open randomised controlled trials comparing antipsychotic drugs in schizophrenia biased? Exploratory meta- and subgroup analysis Open