John M. DeSesso
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View article: Extended one-generation reproductive toxicity study of food-grade titanium dioxide E171 with emphasis on reproductive and endocrine endpoints
Extended one-generation reproductive toxicity study of food-grade titanium dioxide E171 with emphasis on reproductive and endocrine endpoints Open
Food-grade titanium dioxide E171 was administered in feed to Sprague Dawley rats in an extended one-generation reproductive toxicity (EOGRT) study (OECD Test 443). The dosed diet (0, 100, 300, or 1000 mg/kg body weight/day) started 10 week…
View article: A critical look at adjusted fetal weights in rats
A critical look at adjusted fetal weights in rats Open
Background A new derived (i.e., calculated) endpoint of developmental toxicology has appeared in a very few studies since 1990. This endpoint is adjusted mean live fetal weight per litter or adjusted fetal weight. Given our lack of familia…
View article: Commentary: Considering intrauterine location in a model of fetal growth restriction after maternal titanium dioxide nanoparticle inhalation
Commentary: Considering intrauterine location in a model of fetal growth restriction after maternal titanium dioxide nanoparticle inhalation Open
GENERAL COMMENTARY article Front. Toxicol., 04 December 2023Sec. Developmental and Reproductive Toxicology Volume 5 - 2023 | https://doi.org/10.3389/ftox.2023.1293873
View article: Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature
Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature Open
Background Based on new testing, we re‐assess U.S. EPA and California OEHHA conclusions regarding male reproductive toxicity associated with cyanide exposure. Methods Literature identified by ATSDR, ECETOC and EPA was complemented by studi…
View article: Systematic assessment of quaternary ammonium compounds for the potential to elicit developmental and reproductive effects
Systematic assessment of quaternary ammonium compounds for the potential to elicit developmental and reproductive effects Open
Introduction Quaternary ammonium compounds (QUATs) are commonly found in cleaning products, disinfectants, hand sanitizers, and personal care products. They have been used for >50 years and are considered safe when used according to direct…
View article: Workshop to Identify Critical Windows of Exposure for Children's Health: Cardiovascular and Endocrine Work Group Summary
Workshop to Identify Critical Windows of Exposure for Children's Health: Cardiovascular and Endocrine Work Group Summary Open
The work group on cardiovascular and endocrine effects was asked to review the current state of knowledge about children's windows of vulnerability to developmental toxicants and to recommend how that information may be used to improve ris…
View article: Reminiscences of the 36th president
Reminiscences of the 36th president Open
My year as president of the Teratology Society spanned 1994–1995. We renegotiated our contract with Wiley-Liss to continue publishing the journal Teratology for an additional 5 years. The terms of the contract included 12 monthly issues pe…
View article: Comments on “The teratogenic effects of sertraline in mice” (Cabrera et al., 2020 [<scp>DOI</scp>: 10.1002/bdr2.1660])
Comments on “The teratogenic effects of sertraline in mice” (Cabrera et al., 2020 [<span>DOI</span>: 10.1002/bdr2.1660]) Open
There are incorrect statements in the Discussion. The study Results are inappropriately presented and interpreted. There are several issues in Methods. It is unacceptable that a number of citations were misrepresented. J. M. D. teaches Emb…
View article: Response to the comments of Runyan et al. on “Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats”
Response to the comments of Runyan et al. on “Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats” Open
As stated in our Introduction, DeSesso et al. (2019) attempted to replicate the Johnson, Goldberg, Mays, and Dawson (2003) trichloroethylene (TCE) drinking water study in pregnant rats, which reported “abnormal hearts” among offspring of t…
View article: Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats
Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats Open
Background Trichloroethylene (TCE) was negative for developmental toxicity after inhalation and oral gavage exposure of pregnant rats but fetal cardiac defects were reported following drinking water exposure throughout gestation. Because o…
View article: The arrogance of teratology: A brief chronology of attitudes throughout history
The arrogance of teratology: A brief chronology of attitudes throughout history Open
While the discipline of Teratology has existed for about 60 years, there has been a deep interest in the causes of human malformations for millennia. Absent the scientific method and acting on fervent beliefs that made sense to ancient/med…
View article: Impact of chloroform exposures on reproductive and developmental outcomes: A systematic review of the scientific literature
Impact of chloroform exposures on reproductive and developmental outcomes: A systematic review of the scientific literature Open
Aims We assessed the animal and epidemiological data to determine if chloroform exposure causes developmental and/or reproductive toxicity. Results and Discussion Initial scoping identified developmental toxicity as the primary area of con…
View article: Bone development in laboratory mammals used in developmental toxicity studies
Bone development in laboratory mammals used in developmental toxicity studies Open
Evaluation of the skeleton in laboratory animals is a standard component of developmental toxicology testing. Standard methods of performing the evaluation have been established, and modification of the evaluation using imaging technologie…
View article: Conflicting views on the potential carcinogenicity of glyphosate: how did we get here and what should we do?
Conflicting views on the potential carcinogenicity of glyphosate: how did we get here and what should we do? Open
The advent of the internet and the information age has allowed the public to become keenly aware of the perceived dangers to health from polluted air and water, pesticide residues in foods, and global warming. Much of the available informa…
View article: Future of developmental toxicity testing
Future of developmental toxicity testing Open
Protection of developing offspring from the potential adverse effects of in utero exposures is an important aspect of the safety profile for medicines, chemicals and physical agents. The standard safety test design for this type of endpoin…
View article: Vascular ontogeny within selected thoracoabdominal organs and the limbs
Vascular ontogeny within selected thoracoabdominal organs and the limbs Open
The cardiovascular system is fundamental to life. Its vessels are the conduits for delivery of nutrients and oxygen to organs and the removal of wastes. During embryonic development, the vascular system is instrumental in the formation of …