John M. Franck
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View article: Separate and detailed characterization of signal and noise at low resonance frequencies
Separate and detailed characterization of signal and noise at low resonance frequencies Open
When developing or deploying a Nuclear Magnetic Resonance (NMR) spectrometer, especially for Overhauser Dynamic Nuclear Polarization (ODNP) or other experiments that require low-volume low-field measurements, the ability to mitigate noise …
View article: Ultrasound-triggered prodrug activation <i>via</i> sonochemically induced cleavage of a 3,5-dihydroxybenzyl carbamate scaffold
Ultrasound-triggered prodrug activation <i>via</i> sonochemically induced cleavage of a 3,5-dihydroxybenzyl carbamate scaffold Open
Deep-penetrating low-intensity therapeutic ultrasound (LITUS) induces the cleavage of a 3,5-dihydroxybenzyl carbamate (DHBC) prodrug scaffold via a sonochemical activation mechanism, enabling spatiotemporally controlled drug release.
View article: Rapidly Screening the Correlation between the Rotational Mobility and the Hydrogen Bonding Strength of Confined Water
Rapidly Screening the Correlation between the Rotational Mobility and the Hydrogen Bonding Strength of Confined Water Open
Automated Deuterium Relaxation-Ordered SpectroscopY in solution (ADROSYS), an automated two-dimensional deuterium NMR methodology, discriminates between D2O populations (as well as deuterium-labeled alcohol groups) whose properties differ …
View article: Exchange and Microviscosity of Dynamic Nanocompartments
Exchange and Microviscosity of Dynamic Nanocompartments Open
RMs (reverse micelles) provide a controlled system for studying the unique structural and dynamic behaviors of confined water, thus gaining a general insight into the behavior or water under confinement and at interfaces. This study employ…
View article: Computation of Overhauser dynamic nuclear polarization processes reveals fundamental correlation between water dynamics, structure, and solvent restructuring entropy
Computation of Overhauser dynamic nuclear polarization processes reveals fundamental correlation between water dynamics, structure, and solvent restructuring entropy Open
Hydration water dynamics, structure, and thermodynamics are crucially important to understand and predict water-mediated properties at molecular interfaces.
View article: Interfacial B-Site Ion Diffusion in All-Inorganic Core/Shell Perovskite Nanocrystals
Interfacial B-Site Ion Diffusion in All-Inorganic Core/Shell Perovskite Nanocrystals Open
All-inorganic metal halide perovskites (ABX3, X = Cl, Br, or I) show great potential for the fabrication of optoelectronic devices, but the toxicity and instability of lead-based perovskites limit their applications. Shell passivation with…
View article: Contiguous Patches of Translational Hydration Dynamics on the Surface of K-Ras
Contiguous Patches of Translational Hydration Dynamics on the Surface of K-Ras Open
Proteins involved in signaling pathways represent an interesting target for experimental analysis by ODNP (Overhauser Dynamic Nuclear Polarization), which determines the translational mobility at the surface of proteins. They also represen…
View article: Investigating Coordination and Reactivity between an Organohalide and Cesium Lead Halide Nanoparticles via Two-Dimensional DOSY and ROSY NMR
Investigating Coordination and Reactivity between an Organohalide and Cesium Lead Halide Nanoparticles via Two-Dimensional DOSY and ROSY NMR Open
Cesium lead halide (CsPbX3, X = Cl, Br, I) nanoparticles have an inorganic core with propensity for ion exchange that is surrounded by a labile organic capping shell that facilitates ligand exchange, two characteristics that are important …
View article: Direct Observation of the Translational Immobilization of Water Molecules Under Nanoscale Confinement
Direct Observation of the Translational Immobilization of Water Molecules Under Nanoscale Confinement Open
ODNP (Overhauser Dynamic Nuclear Polarization) detects an experimental measurable associated directly with translational motion of water at the nanoscale, a quantity that few other methods can detect. This study offers a unique insight int…
View article: Rapidly Screening the Correlation Between the Rotational Mobility and the Hydrogen Bonding Strength of Confined Water
Rapidly Screening the Correlation Between the Rotational Mobility and the Hydrogen Bonding Strength of Confined Water Open
Past research has conclusively shown that confined pockets of water exhibit properties that differ from those of unconfined ("bulk") water. The differences between confined water and bulk, as well as between different types of confined wat…
View article: NMR, MRI, and spectroscopic MRI in inhomogeneous fields
NMR, MRI, and spectroscopic MRI in inhomogeneous fields Open
A method for locally creating effectively homogeneous or "clean" magnetic field gradients (of high uniformity) for imaging (with NMR, MRI, or spectroscopic MRI) both in in-situ and ex-situ systems with high degrees of inhomogeneous field s…
View article: Inserting an “atomic trap” for directional dopant migration in core/multi-shell quantum dots
Inserting an “atomic trap” for directional dopant migration in core/multi-shell quantum dots Open
Directional Mn dopant migration (outward/inward) was achieved by inserting a CdZnS “atomic trap” with a small size mismatch with dopants in core/multi-shell QDs. A larger initial substitutional site allows for active trapping and dopant mi…
View article: Observing Coordination and Reactivity between an Organohalide and Cesium Lead Halide Nanoparticles via DOSY and ROSY NMR
Observing Coordination and Reactivity between an Organohalide and Cesium Lead Halide Nanoparticles via DOSY and ROSY NMR Open
Cesium lead halide (CsPbX3, X = Cl, Br, I) nanoparticles have an inorganic core with the propensity for ion exchange that is surrounded by a labile ligand capping shell which facilitates ligand exchange, two characteristics that are import…
View article: A modernized view of coherence pathways applied to magnetic resonance experiments in unstable, inhomogeneous fields
A modernized view of coherence pathways applied to magnetic resonance experiments in unstable, inhomogeneous fields Open
This article presents a standardized alternative to the traditional phase cycling approach employed by the overwhelming majority of contemporary Nuclear Magnetic Resonance (NMR) research. On well-tested, stable NMR systems running well-tes…
View article: A Modernized View of Coherence Pathways Applied to Magnetic Resonance\n Experiments in Unstable, Inhomogeneous Fields
A Modernized View of Coherence Pathways Applied to Magnetic Resonance\n Experiments in Unstable, Inhomogeneous Fields Open
Over recent decades, the value of conducting experiments at lower frequencies\nand in inhomogeneous and/or time-variable fields has grown. For example, an\ninterest in the nanoscale heterogeneities of hydration dynamics demands\nincreasing…