Explanipedia

Identifying Pathoadaptation in Pseudomonas aeruginosa Using Glycopolymer Sensor Arrays Open

C. Brent Johnson, Sara Franco Ortega, James Moir, John M. Girkin, Helle Krogh Johansen , et al. · 2025

In-host bacterial evolution presents a major barrier to effective infection management, driving phenotypic adaptations such as antibiotic resistance and altered virulence. Pseudomonas aeruginosa, a key opportunistic pathogen, freque…

Virtually structured illumination for terahertz super-resolution imaging Open

James P. Fleming, Lucy A. Downes, John M. Girkin, Kevin J. Weatherill · 2025

We demonstrate far-field super-resolution imaging in the terahertz (THz) frequency band by using a structured illumination via the virtually structured detection (VSD) method. Leveraging our previously reported high-speed, high-sensitivity…

Biomimetic polypropylene-carbon intra-ply hybrid 3D woven composite with enhanced impact resistance Open

A. S. Weatherburn, Cameron Montgomery, George V. Scott, Calvin Ralph, John M. Girkin , et al. · 2025

Using spatial frequency domain imaging to monitor a skin biopsy wound: a pilot study Open

Lai Zhang, Alistair D. Bounds, John M. Girkin · 2024

Surgical wound infection is a global postoperative issue adding a significant clinical burden and increasing healthcare costs. Early detection and subsequent diagnosis of infection is vital for accurate, early, and effective treatments. In…

Structured illumination for super resolution terahertz imaging Open

James P. Fleming, Lucy A. Downes, John M. Girkin, Kevin J. Weatherill · 2024

Our recent THz imaging system performs full-frame high-speed imaging (12000 fps) by exploiting efficient THz-to-optical conversion in an excited Caesium atomic vapour. Structured Illumination Microscopy (SIM) has revolutionized optical mic…

Monte Carlo simulations and phantom modeling for spatial frequency domain imaging of surgical wound monitoring Open

Lai Zhang, Alistair D. Bounds, John M. Girkin · 2023

We provide guidelines for future SFDI instrument design and explanation for the expected error in SFDI measurements.

Evaluation of cataract formation in fish exposed to environmental radiation at Chernobyl and Fukushima Open

Adélaïde Lerebours, Justyn W. Regini, Roy A. Quinlan, Toshihiro Wada, Barbara Pierścionek , et al. · 2023

Recent studies apparently finding deleterious effects of radiation exposure on cataract formation in birds and voles living near Chernobyl represent a major challenge to current radiation protection regulations. This study conducted an int…

Bullseye Analysis: A Fluorescence Microscopy Technique to Detect Local Changes in Intracellular Reactive Oxygen Species (ROS) Production Open

Joshua G. Hughes, David R. Chisholm, Andrew Whiting, John M. Girkin, Carrie A. Ambler · 2022

Reactive oxygen species (ROS) are naturally produced compounds that play important roles in cell signaling, gene regulation, and biological defense, including involvement in the oxidative burst that is central to the anti-microbial actions…

Integrated fiber optic spectrally resolved downwelling irradiance sensor for pushbroom spectrometers Open

Christopher Graham, John M. Girkin, Cyril Bourgenot · 2022

We present an integrated fiber optic spectrally resolved downwelling irradiance sensor for pushbroom hyperspectral imagers. The system comprises of a cosine corrector and custom fiber patch cables, collecting the ambient light in a large s…

Spectral index selection method for remote moisture sensing under challenging illumination conditions Open

Christopher Graham, John M. Girkin, Cyril Bourgenot · 2022

Full spectrum fluorescence lifetime imaging with 0.5 nm spectral and 50 ps temporal resolution Open

Gareth Williams, Elvira Williams, Neil Finlayson, Ahmet T. Erdogan, Qiang Wang , et al. · 2021

The use of optical techniques to interrogate wide ranging samples from semiconductors to biological tissue for rapid analysis and diagnostics has gained wide adoption over the past decades. The desire to collect ever more spatially, spectr…

Freeform based hYperspectral imager for MOisture Sensing (FYMOS) Open

Christopher Graham, John M. Girkin, Cyril Bourgenot · 2021

We present FYMOS, an all-aluminum, robust, light weight, freeform based, near infrared hYperspectral imager for MOisture Sensing. FYMOS was designed and built to remotely measure moisture content using spectral features from 0.7-1.7µm inte…

LightBox: A multiwell plate illumination system for photoactive molecule characterization Open

Alistair D. Bounds, R.D. Bailey, Candace Adams, D.C. Callaghan, John M. Girkin · 2021

Multiwell plates (MWPs) are the workhorses of the life sciences. However, biophotonics research with MWPs is limited, in part due to the lack of equipment suitable for photo‐irradiation of photoactive molecules in a MWP‐suitable, high‐thro…

Early stage dental caries detection using near infrared spatial frequency domain imaging Open

Alistair D. Bounds, John M. Girkin · 2021

A history of high-power laser research and development in the United Kingdom Open

C. Danson, M. S. White, J.R.M. Barr, Thomas H. Bett, Peter L. Blyth , et al. · 2021

The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. I…

Feature issue introduction: applications of adaptive optics Open

Julian C. Christou, John M. Girkin, Caroline Kulcsár, Laura K. Young · 2020

This feature issue of Optics Express follows the 2020 Imaging and Applied Optics Congress and comprises of articles on the development and use of adaptive optics across the broad range of domains in which the technique has been applied - i…

Three-dimensional data capture and analysis of intact eye lenses evidences emmetropia-associated changes in epithelial cell organization Open

Alexia A. Kalligeraki, Archie Isted, Miguel Jarrı́n, Alice Uwineza, Róbert Pál , et al. · 2020

Using FRAP as a Technique to Quantitate Local Reactive Oxygen Species (ROS) Production Open

J. C. Hughes, David R. Chisholm, Carrie A. Ambler, Andrew Whiting, John M. Girkin · 2020

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Cellular localisation of structurally diverse diphenylacetylene fluorophores Open

David R. Chisholm, Joshua G. Hughes, Thomas S. Blacker, Rachel Humann, Candace Adams , et al. · 2020

The cellular localisation of diphenylacetylene fluorophores can be influenced by modifying their structure, modulating lipophilicity and incorporating ionisable groups.

CCDC 1854354: Experimental Crystal Structure Determination Open

David R. Chisholm, Rebecca Lamb, Tommy Pallett, Valerie Affleck, Claire Holden , et al. · 2019

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Multi-plane remote refocusing epifluorescence microscopy to image dynamic Ca2+events Open

Penelope F. Lawton, Charlotte Buckley, Chris D. Saunter, Calum Wilson, Alexander D. Corbett , et al. · 2019

Rapid imaging of multiple focal planes without sample movement may be achieved through remote refocusing, where imaging is carried out in a plane conjugate to the sample plane. The technique is ideally suited to studying the endothelial an…

Scattering of spoof surface plasmon polaritons in defect-rich THz waveguides Open

Andreas K. Klein, Alastair Basden, Jonathan Hammler, Luke Tyas, Michael Cooke , et al. · 2019

VasoTracker, a Low-Cost and Open Source Pressure Myograph System for Vascular Physiology Open

Penelope F. Lawton, Matthew D. Lee, Christopher D. Saunter, John M. Girkin, John G. McCarron , et al. · 2019

Pressure myography, one of the most commonly used techniques in vascular research, measures the diameter of isolated, pressurized arteries to assess the functional activity of smooth muscle and endothelial cells. Despite the widespread ado…

A CMOS SPAD Line Sensor With Per-Pixel Histogramming TDC for Time-Resolved Multispectral Imaging Open

Ahmet T. Erdogan, Richard Walker, Neil Finlayson, Nikola Krstajić, Gareth Williams , et al. · 2019

A 512 × 16 single photon avalanche diode (SPAD)-based line sensor is designed in a 0.13- μm CMOS image sensor technology for time-resolved multispectral beam scanned imaging. The sensor has 23.78- μm pixel pitch and incorporates one SPAD a…

Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene Open

David R. Chisholm, Rebecca Lamb, Tommy Pallett, Valerie Affleck, Claire Holden , et al. · 2019

Drug-like, donor–acceptor diphenylacetylenes cause efficient cell death upon photoactivation and hence have potential phototherapeutic applications.

Author Index Open

Klaus Aktories, Mohammad Ali, Claudia Angelini, B Baglivo, Eli Bar , et al. · 2019

High-speed dual color fluorescence lifetime endomicroscopy for highly-multiplexed pulmonary diagnostic applications and detection of labeled bacteria Open

E. Pedretti, Michael G. Tanner, Tushar R. Choudhary, Nikola Krstajić, Alicia Megía-Fernández , et al. · 2018

We present a dual-color laser scanning endomicroscope capable of fluorescence lifetime endomicroscopy at one frame per second (FPS). The scanning system uses a coherent imaging fiber with 30,000 cores. High-speed lifetime imaging is achiev…

Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate–evoked calcium signaling Open

Calum Wilson, Matthew D. Lee, Helen R. Heathcote, Xun Zhang, Charlotte Buckley , et al. · 2018

High-speed dual color fluorescence lifetime endomicroscopy for\n highly-multiplexed pulmonary diagnostic applications and detection of labeled\n bacteria Open

E. Pedretti, Michael G. Tanner, Tushar R. Choudhary, Nikola Krstajić, Alicia Megía-Fernández , et al. · 2018

We present a dual color laser scanning endomicroscope capable of fluorescence\nlifetime endomicroscopy at one frame per second (FPS). The scanning system uses\na coherent imaging fiber with 30,000 cores. High-speed lifetime imaging is\nach…

High-speed dual color fluorescence lifetime endomicroscopy for highly-multiplexed pulmonary diagnostic applications and detection of labeled bacteria Open

E. Pedretti, Michael G. Tanner, Tushar R. Choudhary, Nikola Krstajić, Alicia Megía-Fernández , et al. · 2018

We present a dual color laser scanning endomicroscope capable of fluorescence lifetime endomicroscopy at one frame per second (FPS). The scanning system uses a coherent imaging fiber with 30,000 cores. High-speed lifetime imaging is achiev…

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