John M. Talbott
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View article: Coarctate reaction for synthesis of fluorescent N-heterocycles, late-stage functionalization, and photo-triggered drug delivery
Coarctate reaction for synthesis of fluorescent N-heterocycles, late-stage functionalization, and photo-triggered drug delivery Open
Coarctate reactions, involving the simultaneous formation and cleavage of two bonds at single or multiple atoms, have remained largely unexplored for biomolecular applications. These reactions are characterized by complex helical orbitals …
View article: Spatiotemporal Imaging of Catechol Aldehydes in Neural Tissue
Spatiotemporal Imaging of Catechol Aldehydes in Neural Tissue Open
Catechol aldehydes (CAs), particularly 3,4-dihydroxyphenylacetaldehyde (DOPAL) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), are potently cytotoxic and have been implicated in pathogenesis of neurodegenerative disorders. Understanding t…
View article: Selective Sensing of Catechol Aldehydes Levels in Living Systems using FLIM-FRET
Selective Sensing of Catechol Aldehydes Levels in Living Systems using FLIM-FRET Open
Endogenous catechol aldehydes (CAs), namely 3,4-dihydroxyphenylacetaldehyde (DOPAL) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), play pivotal roles in neurobehavioral, cardiovascular, and metabolic processes. Dysregulation of CA levels…
View article: Tunable fluorescent probes for detecting aldehydes in living systems
Tunable fluorescent probes for detecting aldehydes in living systems Open
Introducing 4-amino-3-thiophenol BODIPY “turn on” probe tunable to NIR wavelengths for monitoring aldehydes in tissues and living organoids by forming dihydrobenzothiazole products with aldehydes, exhibiting a remarkable fluorescence incre…
View article: Correction to “C-Terminal Arginine-Selective Cleavage of Peptides as a Method for Mimicking Carboxypeptidase B”
Correction to “C-Terminal Arginine-Selective Cleavage of Peptides as a Method for Mimicking Carboxypeptidase B” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "C-Terminal Arginine-Selective Cleavage of Peptides as a Method for Mimicking Carboxypeptidase B"Lyndsey C. ProsserLyn…
View article: Improved Triplex‐Forming Isoorotamide PNA Nucleobases for A−U Recognition of RNA Duplexes**
Improved Triplex‐Forming Isoorotamide PNA Nucleobases for A−U Recognition of RNA Duplexes** Open
Four new isoorotamide ( Io )‐containing PNA nucleobases have been designed for A−U recognition of double helical RNA. New PNA monomers were prepared efficiently and incorporated into PNA nonamers for binding A−U in a PNA:RNA 2 triplex. Iso…
View article: C-Terminal Arginine-Selective Cleavage of Peptides as a Method for Mimicking Carboxypeptidase B
C-Terminal Arginine-Selective Cleavage of Peptides as a Method for Mimicking Carboxypeptidase B Open
C-Terminal residues play a pivotal role in dictating the structure and functions of proteins. Herein, we report a mild, efficient, chemoselective, and site-selective chemical method that allows for precise chemical proteolysis at C-termina…