John Malysz
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Differential effects of <span>TRPM4</span> channel inhibitors on Guinea pig urinary bladder smooth muscle excitability and contractility: Novel 4‐chloro‐2‐[2‐(2‐chloro‐phenoxy)‐acetylamino]‐benzoic acid (<span>CBA</span>) versus classical 9‐phenanthrol Open
Non‐selective cation channels in urinary bladder smooth muscle (UBSM) are thought to mediate increases in cellular excitability and contractility. For transient receptor potential melastatin type‐4 (TRPM4) channels, the evidence primarily …
Age‐dependent decrease in TRPM4 channel expression but not trafficking alters urinary bladder smooth muscle contractility Open
During development, maturation, or aging, the expression and function of urinary bladder smooth muscle (UBSM) ion channels can change, thus affecting micturition. Increasing evidence supports a novel role of transient receptor potential me…
Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function Open
Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized act…
Urinary bladder smooth muscle ion channels: expression, function, and regulation in health and disease Open
Urinary bladder smooth muscle (UBSM), also known as detrusor smooth muscle, forms the bladder wall and ultimately determines the two main attributes of the organ: urine storage and voiding. The two functions are facilitated by UBSM relaxat…
Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents Open
Detrusor smooth muscle (DSM) cells present within the urinary bladder wall ultimately facilitate urine storage and voiding. Preparation of the viable, fresh, and isolated DSM cells presents an important technical challenge whose achievemen…
TRPM4 channel inhibitors 9-phenanthrol and glibenclamide differentially decrease guinea pig detrusor smooth muscle whole-cell cation currents and phasic contractions Open
Nonselective cation channels, consistent with transient receptor potential melastatin-4 (TRPM4), regulate detrusor smooth muscle (DSM) function. TRPM4 channels can exist as homomers or assemble with sulfonylurea receptors (SURs) as complex…
Extracellular pH and intracellular phosphatidylinositol 4,5-bisphosphate control Cl<sup>−</sup> currents in guinea pig detrusor smooth muscle cells Open
Cl − channels serve as key regulators of excitability and contractility in vascular, intestinal, and airway smooth muscle cells. We recently reported a Cl − conductance in detrusor smooth muscle (DSM) cells. Here, we used the whole cell pa…
Properties of single-channel and whole cell Cl<sup>−</sup> currents in guinea pig detrusor smooth muscle cells Open
Multiple types of Cl − channels regulate smooth muscle excitability and contractility in vascular, gastrointestinal, and airway smooth muscle cells. However, little is known about Cl − channels in detrusor smooth muscle (DSM) cells. Here, …
Extracellular Cl<sup>−</sup> regulates electrical slow waves and setting of smooth muscle membrane potential by interstitial cells of Cajal in mouse jejunum Open
New Findings What is the central question of this study? The aim was to investigate the roles of extracellular chloride in electrical slow waves and resting membrane potential of mouse jejunal smooth muscle by replacing chloride with the i…
Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca<sup>2+</sup>transients and slow waves in adult mouse small intestine Open
Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit + electrical pacemakers that express the Ano1/TMEM16A Ca 2+ -activated Cl – channel, whose functions in the gastrointestinal tract remain incompletely und…
Novel regulatory mechanism in human urinary bladder: central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function Open
Transient receptor potential melastatin 4 (TRPM4) channels are Ca 2+ -activated nonselective cation channels that have been recently identified as regulators of detrusor smooth muscle (DSM) function in rodents. However, their expression an…