Michael J. Brady
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View article: Actin Pedestal Formation by Enterohemorrhagic Escherichia coli Enhances Bacterial Host Cell Attachment and Concomitant Type III Translocation
Actin Pedestal Formation by Enterohemorrhagic Escherichia coli Enhances Bacterial Host Cell Attachment and Concomitant Type III Translocation Open
Attachment of enterohemorrhagic Escherichia coli (EHEC) to intestinal epithelial cells is critical for colonization and is associated with localized actin assembly beneath bound bacteria. The formation of these actin “pedestals” is depende…
View article: Allele- and Tir-Independent Functions of Intimin in Diverse Animal Infection Models
Allele- and Tir-Independent Functions of Intimin in Diverse Animal Infection Models Open
Upon binding to intestinal epithelial cells, enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli (EPEC), and Citrobacter rodentium trigger formation of actin pedestals beneath bound bacteria. Pedestal formation has been ass…
View article: Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host
Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host Open
Upon intestinal colonization, enterohemorrhagic Escherichia coli (EHEC) induces epithelial cells to generate actin "pedestals" beneath bound bacteria, lesions that promote colonization. To induce pedestals, EHEC utilizes a type III secreti…
View article: Enterohemorrhagic E. coli Requires N-WASP for Efficient Type III Translocation but Not for EspFU-Mediated Actin Pedestal Formation
Enterohemorrhagic E. coli Requires N-WASP for Efficient Type III Translocation but Not for EspFU-Mediated Actin Pedestal Formation Open
Upon infection of mammalian cells, enterohemorrhagic E. coli (EHEC) O157:H7 utilizes a type III secretion system to translocate the effectors Tir and EspF(U) (aka TccP) that trigger the formation of F-actin-rich 'pedestals' beneath bound b…
View article: Targeting Type III Secretion in <i>Yersinia pestis</i>
Targeting Type III Secretion in <i>Yersinia pestis</i> Open
Yersinia pestis , the causative agent of plague, utilizes a plasmid-encoded type III secretion system (T3SS) to aid it with its resistance to host defenses. This system injects a set of effector proteins known as Yops ( Yersinia outer prot…
View article: EspF<sub>U</sub>, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7
EspF<sub>U</sub>, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7 Open
Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 induces filamentous actin-rich 'pedestals' on intestinal epithelial cells. Pedestal formation in vitro requires translocation of bacterial effectors into the host cell, including Tir, an E…
View article: Enterohaemorrhagic and enteropathogenic<i>Escherichia coli</i>Tir proteins trigger a common Nck-independent actin assembly pathway
Enterohaemorrhagic and enteropathogenic<i>Escherichia coli</i>Tir proteins trigger a common Nck-independent actin assembly pathway Open
The Tir proteins of enterohaemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC respectively) are each translocated into the host plasma membrane where they promote F-actin pedestals in epithelial cells beneath adherent bacteri…
View article: Mechanism and Function of Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7: A Dissertation
Mechanism and Function of Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7: A Dissertation Open
Enterohemorrhagic Escherichia coli O157:H7 (EHEC) and enteropathogenic E. coli O127:H7 (EPEC) induce characteristic F-actin rich pedestals on infected mammalian cells. Each pathogen delivers its own translocated intimin receptor (Tir) …
View article: Transition from Shelf to Basinal Carbonates in Middle Cambrian Marjum Formation of House Range, Western Utah--Paleoenvironmental Analysis: ABSTRACT
Transition from Shelf to Basinal Carbonates in Middle Cambrian Marjum Formation of House Range, Western Utah--Paleoenvironmental Analysis: ABSTRACT Open
Lithofacies of the Marjum Formation in the House Range of west-central Utah indicate that a rather abrupt transition from shallow-shelf to basinal depositional environments persisted in this locality during much of the Middle Cambrian. The…
View article: Diagenesis of Carbonate Muds in Lagoons of Northeast Yucatan Peninsula, Mexico: ABSTRACT
Diagenesis of Carbonate Muds in Lagoons of Northeast Yucatan Peninsula, Mexico: ABSTRACT Open
Carbonate muds deposited in extensive coastal lagoons bordering the northeast Yucatan Peninsula have been subjected to a variety of diagenetic environments. The sediment in each of these environments is characterized by a particular suite …