John Moat
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View article: Membrane lipid composition directs the cellular selectivity of antimicrobial metallohelices
Membrane lipid composition directs the cellular selectivity of antimicrobial metallohelices Open
One peptidomimetic metallohelix architecture has a balance of charge and lipophilicity that favours selective cell entry in E. coli over mammalian cells, while a closely related structure is promiscuous and unselective.
View article: Genomic Assembly of Clinical Candida glabrata (Nakaseomyces glabrata) Isolates Reveals within-Species Structural Plasticity and Association with <i>In Vitro</i> Antifungal Susceptibility
Genomic Assembly of Clinical Candida glabrata (Nakaseomyces glabrata) Isolates Reveals within-Species Structural Plasticity and Association with <i>In Vitro</i> Antifungal Susceptibility Open
The human pathogen Candida glabrata has become a global threat to human health, with infections characterized by high mortality and multidrug resistance. We have obtained nine fully assembled genomes from clinical isolates through a combin…
View article: Antibiotic Efficacy Testing in an Ex vivo Model of <em>Pseudomonas aeruginosa</em> and <em>Staphylococcus aureus</em> Biofilms in the Cystic Fibrosis Lung
Antibiotic Efficacy Testing in an Ex vivo Model of <em>Pseudomonas aeruginosa</em> and <em>Staphylococcus aureus</em> Biofilms in the Cystic Fibrosis Lung Open
The effective prescription of antibiotics for the bacterial biofilms present within the lungs of individuals with cystic fibrosis (CF) is limited by a poor correlation between antibiotic susceptibility testing (AST) results using standard …
View article: CAUTI’s Next Top Model – model dependent<i>Klebsiella</i>biofilm inhibition by bacteriophages and antimicrobials
CAUTI’s Next Top Model – model dependent<i>Klebsiella</i>biofilm inhibition by bacteriophages and antimicrobials Open
Klebsiella infections, including catheter associated urinary tract infections, are a considerable burden on health care systems. This is due to their difficulty to treat, caused by antimicrobial resistance and their ability to form biofilm…
View article: Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients
Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients Open
Novel antimicrobials are urgently needed to combat the increasing occurrence of drug-resistant bacteria and to overcome the inherent difficulties in treating biofilm-associated infections. Research into natural antimicrobials could provide…
View article: Investigating Bacteriophages Targeting the Opportunistic Pathogen Acinetobacter baumannii
Investigating Bacteriophages Targeting the Opportunistic Pathogen Acinetobacter baumannii Open
The multi-drug resistance of the opportunistic pathogen Acinetobacter baumannii is of growing concern, with many clinical isolates proving to be resistant to last resort as well as front line antibiotic treatments. The use of bacteriophage…
View article: Metal complexes as a promising source for new antibiotics
Metal complexes as a promising source for new antibiotics Open
There is a dire need for new compounds to combat antibiotic resistance: metal complexes might provide the solution. 906 metal complexes were evaluated against dangerous ESKAPE pathogens and found to have a higher hit-rate than organic mole…
View article: Correction: Metal complexes as a promising source for new antibiotics
Correction: Metal complexes as a promising source for new antibiotics Open
Correction for ‘Metal complexes as a promising source for new antibiotics’ by Angelo Frei et al., Chem. Sci., 2020, 11, 2627–2639.
View article: Metal Complexes as a Promising Source for New Antibiotics
Metal Complexes as a Promising Source for New Antibiotics Open
There is a dire need for new classes of antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classe…
View article: Metal Complexes as a Promising Source for New Antibiotics
Metal Complexes as a Promising Source for New Antibiotics Open
There is a dire need for new classes of antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classe…
View article: Metal Complexes as a Promising Source for New Antibiotics
Metal Complexes as a Promising Source for New Antibiotics Open
There is a dire need for new classes of antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classe…
View article: Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways
Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways Open
Iron-based self-assembled optically pure compounds mimic the mechanisms of small peptides, according to biophysical, genomic, transcriptomic and other analyses.
View article: Data for Biguanide iridium(III) complexes with potent antimicrobial activity
Data for Biguanide iridium(III) complexes with potent antimicrobial activity Open
We have synthesized novel organoiridium(III) antimicrobial complexes containing a chelated biguanide, including the antidiabetic drug metformin. These 16- and 18-electron complexes were characterized by NMR, ESI-MS, elemental analysis, and…
View article: Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity Open
We have synthesized novel organoiridium(III) antimicrobial complexes containing a chelated biguanide, including the antidiabetic drug metformin. These 16- and 18-electron complexes were characterized by NMR, ESI-MS, elemental analysis, and…
View article: Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform
Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform Open
The results suggest that the bacterial community diversity captured using the V3-V4 16S rRNA hypervariable region from sequencing using the MiSeq platform is comparable to the Roche454 GS Junior platform. These findings provide evidence th…
View article: Domestic shower hose biofilms contain fungal species capable of causing opportunistic infection
Domestic shower hose biofilms contain fungal species capable of causing opportunistic infection Open
The domestic environment can be a source of pathogenic bacteria. We show here that domestic shower hoses may harbour potentially pathogenic bacteria and fungi. Well-developed biofilms were physically removed from the internal surface of sh…