John N. Kheir
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View article: Hydrogen’s Feasibility and Safety as a Therapy in Extracorporeal Cardiopulmonary Resuscitation (Hydrogen-FAST): study protocol for a trial of inhaled hydrogen gas as an adjunctive therapy in refractory cardiac arrest
Hydrogen’s Feasibility and Safety as a Therapy in Extracorporeal Cardiopulmonary Resuscitation (Hydrogen-FAST): study protocol for a trial of inhaled hydrogen gas as an adjunctive therapy in refractory cardiac arrest Open
View article: Rapidly dissolving polymeric microbubbles promote supersaturation and in-situ formation of acoustic nanobubbles capable of dynamic pressure sensing
Rapidly dissolving polymeric microbubbles promote supersaturation and in-situ formation of acoustic nanobubbles capable of dynamic pressure sensing Open
View article: Automated phenotyping of congenital heart disease for dynamic patient aggregation and outcome reporting
Automated phenotyping of congenital heart disease for dynamic patient aggregation and outcome reporting Open
Objectives Accurate characterization of patients with congenital heart disease is fundamental to research, outcomes reporting, quality improvement, and clinical decision-making. Here we present an approach to computing the anatomy of patie…
View article: Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO
Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO Open
View article: Generating Risk Reduction Analytics in Complex Cardiac Care Environments (GR2AC3E): Risk Prediction in Congenital Catheterization
Generating Risk Reduction Analytics in Complex Cardiac Care Environments (GR2AC3E): Risk Prediction in Congenital Catheterization Open
View article: Biventricular Repair of Univentricular Heart Lowers Risk of Liver Disease Compared With the Fontan Operation
Biventricular Repair of Univentricular Heart Lowers Risk of Liver Disease Compared With the Fontan Operation Open
Among a contemporary cohort of patients with single ventricle anatomy, BiV provide comparable long-term survival and lower risk of liver disease when compared to patients who have undergoing Fontan operations.
View article: Systemically injected oxygen within rapidly dissolving microbubbles improves the outcomes of severe hypoxaemia in swine
Systemically injected oxygen within rapidly dissolving microbubbles improves the outcomes of severe hypoxaemia in swine Open
View article: Esophageal oxyhemoglobin saturation as a resuscitative metric in hemorrhagic shock
Esophageal oxyhemoglobin saturation as a resuscitative metric in hemorrhagic shock Open
Background Mixed venous saturation (SvO2) is considered the gold standard to assess the adequacy of tissue oxygen delivery (DO2) in shock states. However, SvO2 monitoring is challenging as it requires an invasive catheter and frequent bloo…
View article: The importance of resource awareness in artificial intelligence for healthcare
The importance of resource awareness in artificial intelligence for healthcare Open
Artificial intelligence and machine learning (AI/ML) models have been adopted in a wide range of healthcare applications, from medical image computing and analysis to continuous health monitoring and management. Recent data have demonstrat…
View article: Predicting favorable response to intravenous morphine in pediatric critically ill cardiac patients
Predicting favorable response to intravenous morphine in pediatric critically ill cardiac patients Open
Introduction Analgesia and sedation are integral to the care of critically ill children. However, the choice and dose of the analgesic or sedative drug is often empiric, and models predicting favorable responses are lacking. We aimed to co…
View article: POS1476 AUTOANTIBODY TRAJECTORIES ASSOCIATE WITH CLASSIFICATION AND TREATMENT RESPONSE IN LUPUS NEPHRITIS
POS1476 AUTOANTIBODY TRAJECTORIES ASSOCIATE WITH CLASSIFICATION AND TREATMENT RESPONSE IN LUPUS NEPHRITIS Open
View article: POS0289 SERUM SOLUBLE MEDIATOR SIGNATURES OF LUPUS NEPHRITIS HISTOLOGICAL FEATURES AND RESPONSE TO TREATMENT
POS0289 SERUM SOLUBLE MEDIATOR SIGNATURES OF LUPUS NEPHRITIS HISTOLOGICAL FEATURES AND RESPONSE TO TREATMENT Open
View article: A microfluidic device for real-time on-demand intravenous oxygen delivery
A microfluidic device for real-time on-demand intravenous oxygen delivery Open
Significance The treatment of hypoxemia that is refractory to the current standard of care is time-sensitive and requires skilled caregivers and use of specialized equipment (e.g., extracorporeal membrane oxygenation). Most patients experi…
View article: Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults
Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults Open
BACKGROUND: Ischemia-reperfusion injury is common in critically ill patients, and directed therapies are lacking. Inhaled hydrogen gas diminishes ischemia-reperfusion injury in models of shock, stroke, and cardiac arrest. The purpose of th…
View article: Contrastive Learning with Temporal Correlated Medical Images: A Case Study using Lung Segmentation in Chest X-Rays
Contrastive Learning with Temporal Correlated Medical Images: A Case Study using Lung Segmentation in Chest X-Rays Open
Contrastive learning has been proved to be a promising technique for image-level representation learning from unlabeled data. Many existing works have demonstrated improved results by applying contrastive learning in classification and obj…
View article: Patch augmentation of small ascending aorta during stage I procedure reduces the risk of morbidity and mortality
Patch augmentation of small ascending aorta during stage I procedure reduces the risk of morbidity and mortality Open
OBJECTIVES Hypoplastic left heart syndrome (HLHS) with aortic atresia (AA) patients are prone to coronary insufficiency due to a small ascending aorta. Prophylactic patch augmentation of the small ascending aorta during the stage I procedu…
View article: Development of Care Curves Following the Stage 1 Palliation: A Comparison of Intensive Care Among 5 Centers
Development of Care Curves Following the Stage 1 Palliation: A Comparison of Intensive Care Among 5 Centers Open
Background Comparison of care among centers is currently limited to major end points, such as mortality, length of stay, or complication rates. Creating “care curves” and comparing individual elements of care over time may highlight modifi…
View article: Commentary: Hydrogen: Lightweight molecule takes on a heavyweight problem
Commentary: Hydrogen: Lightweight molecule takes on a heavyweight problem Open
View article: Socioeconomic and Racial and/or Ethnic Disparities in Multisystem Inflammatory Syndrome
Socioeconomic and Racial and/or Ethnic Disparities in Multisystem Inflammatory Syndrome Open
OBJECTIVES: To characterize the socioeconomic and racial and/or ethnic disparities impacting the diagnosis and outcomes of multisystem inflammatory syndrome in children (MIS-C). METHODS: This multicenter retrospective case-control study wa…
View article: Complete Heart Block, Severe Ventricular Dysfunction, and Myocardial Inflammation in a Child With COVID-19 Infection
Complete Heart Block, Severe Ventricular Dysfunction, and Myocardial Inflammation in a Child With COVID-19 Infection Open
A young child presented with severe ventricular dysfunction and troponin leak in the setting of coronavirus disease-2019. He developed intermittent, self-resolving, and hemodynamically insignificant episodes of complete heart block that we…
View article: Red Blood Cell Transfusion After Stage I Palliation Is Associated With Worse Clinical Outcomes
Red Blood Cell Transfusion After Stage I Palliation Is Associated With Worse Clinical Outcomes Open
Background Packed red blood cell transfusion may improve oxygen content in single‐ventricle neonates, but its effect on clinical outcomes after Stage 1 palliation is unknown. Methods and Results Retrospective multicenter analysis of packed…
View article: WITHDRAWN: Complete Heart Block, Severe Ventricular Dysfunction and Myocardial Inflammation in a Child with COVID-19 Infection
WITHDRAWN: Complete Heart Block, Severe Ventricular Dysfunction and Myocardial Inflammation in a Child with COVID-19 Infection Open
The Publisher regrets that this article is an accidental duplication of an article that has already been published, https://doi.org/10.1016/j.jaccas.2020.05.023>. The duplicate article has therefore been withdrawn. The full Elsevier Policy…
View article: Development of a Respiratory Support Score as a Visualization Tool in Intensive Care
Development of a Respiratory Support Score as a Visualization Tool in Intensive Care Open
Elements of respiratory support can be automatically extracted and transformed into a numerical RSS for visualization of respiratory course. The RSS provides a clear visual depiction of respiratory care over time, particularly in subjects …
View article: Value of Troponin Testing for Detection of Heart Disease in Previously Healthy Children
Value of Troponin Testing for Detection of Heart Disease in Previously Healthy Children Open
Background Troponin levels are frequently obtained in pediatric patients, but the benefit remains unclear. Methods and Results This retrospective study included 1993 patients aged 0 to 21 years without history of cardiac disease in whom tr…
View article: Fontan with lateral tunnel is associated with improved survival compared with extracardiac conduit
Fontan with lateral tunnel is associated with improved survival compared with extracardiac conduit Open
View article: Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine
Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine Open
This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and rena…
View article: Frontispiece: Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science
Frontispiece: Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science Open
Intravascular oxygen delivery holds great potential for the treatment of numerous hypoxic conditions and emergencies, including pulmonary disorders, hypoxic tumors, hemorrhagic shock, stroke, cardiac arrest and so on. Different biomaterial…
View article: Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study
Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study Open
Introduction: Direct comparison of the effects of antiarrhythmic agents on myocardial performance may be useful in choosing between medications in critically ill patients. Studies directly comparing multiple antiarrhythmic medications are …
View article: Impact of a Composite Valved RV-PA Graft After Stage 1 Palliation
Impact of a Composite Valved RV-PA Graft After Stage 1 Palliation Open
View article: An anticoagulation protocol for use after congenital cardiac surgery
An anticoagulation protocol for use after congenital cardiac surgery Open