Michael J. O’Brien
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View article: Initiating Testosterone Therapy Without Indication for Treatment of Low Testosterone Is Associated With Higher Risk of Tendon Tear
Initiating Testosterone Therapy Without Indication for Treatment of Low Testosterone Is Associated With Higher Risk of Tendon Tear Open
Background: Studies have demonstrated an increasing rate of testosterone supplementation in patients who do not meet criteria for testosterone deficiency, but the risks associated with testosterone supplementation are unclear. Hypothesis: …
View article: Sport-Related Injury and Performance Enhancing Substance Use by Young Athletes
Sport-Related Injury and Performance Enhancing Substance Use by Young Athletes Open
Background: Legal performance enhancing substance (PES) use is increasing in young athletes and may lead to banned PES use. This study examines legal PES use and consideration of banned PES use in young athletes with a season-ending injury…
View article: 236 A pilot and evaluation of a dance intervention for young women following cancer treatment: Dance Exercise Intervention South East (The DEISE project)
236 A pilot and evaluation of a dance intervention for young women following cancer treatment: Dance Exercise Intervention South East (The DEISE project) Open
Purpose There is emergent and strong evidence for effectiveness of dance-based physical activity for young women post cancer treatment. However, there is a need for knowledge on such physical activity implementation in a community setting.…
View article: Operative Treatment of Ulnar Collateral Ligament Injury in Female Athletes
Operative Treatment of Ulnar Collateral Ligament Injury in Female Athletes Open
Background: Ulnar collateral ligament (UCL) reconstruction has been the standard surgical intervention for elite male athletes with UCL insufficiency. Recently, UCL repair and augmentation with an internal brace has been increasingly perfo…
View article: Genome-wide analysis of TFIIB’s role in termination of transcription
Genome-wide analysis of TFIIB’s role in termination of transcription Open
Apart from its well-established role in initiation of transcription, the general transcription factor TFIIB has been implicated in the termination step as well. The ubiquity of TFIIB involvement in termination as well as mechanistic detail…
View article: Sport specialisation and performance-enhancing substance use by young athletes
Sport specialisation and performance-enhancing substance use by young athletes Open
Objectives To investigate the association of reported legal performance enhancing substance (PES) use and consideration of banned PES use among sport-specialised and non-sport-specialised young athletes. Methods and design Cross-sectional …
View article: Fixation devices for anterior shoulder instability
Fixation devices for anterior shoulder instability Open
Purpose Over the past 40 years, advances in the development of anchors and sutures have contributed to the improvement in surgical outcomes for treatment of shoulder instability. Important choices in surgery when treating instability inclu…
View article: Protein interaction network revealed by quantitative proteomic analysis elucidates TFIIB role in multiple aspects of the transcription cycle
Protein interaction network revealed by quantitative proteomic analysis elucidates TFIIB role in multiple aspects of the transcription cycle Open
TFIIB is implicated in multiple aspects of eukaryotic transcription. To investigate the broader role of TFIIB in transcription, we performed quantitative proteomic analysis of yeast TFIIB. We purified TFIIB from soluble cell lysate and the…
View article: Integrated Features for Optimizing Machine Learning Classifiers of Pediatric and Young Adults With a Post-Traumatic Headache From Healthy Controls
Integrated Features for Optimizing Machine Learning Classifiers of Pediatric and Young Adults With a Post-Traumatic Headache From Healthy Controls Open
Post-traumatic headache (PTH) is a challenging clinical condition to identify and treat as it integrates multiple subjectively defined symptoms with underlying physiological processes. The precise mechanisms underlying PTH are unclear, and…
View article: Uncovering Ankylosing Spondylitis from a Diagnosis of Parsonage-Turner Syndrome: A Case Report of Bilateral Shoulder Pain and Weakness
Uncovering Ankylosing Spondylitis from a Diagnosis of Parsonage-Turner Syndrome: A Case Report of Bilateral Shoulder Pain and Weakness Open
Introduction: Parsonage-Turner syndrome is a rare condition that is often misdiagnosed by physicians due to the overlapping symptoms with other conditions such as rotator cuff injury and cervical radiculopathy. The etiology of the Parsonag…
View article: Association between post-concussion symptoms and oculomotor deficits among adolescents
Association between post-concussion symptoms and oculomotor deficits among adolescents Open
High PCSS scores may indicate an accommodation deficit and thus prompt an oculomotor assessment in patients following a concussion. Using the CISS and a detailed oculomotor assessment may reveal underlying oculomotor deficits, which may be…
View article: Medial Ulnar Collateral Ligament Repair With Internal Brace Augmentation: Results in 40 Consecutive Patients
Medial Ulnar Collateral Ligament Repair With Internal Brace Augmentation: Results in 40 Consecutive Patients Open
Background: Medial ulnar collateral ligament (MUCL) repair has been proven to be effective in nonprofessional overhead-throwing athletes, with faster and higher rates of return to play (RTP) than the more traditional Tommy John reconstruct…
View article: Clinical Outcomes of Shoulder Stabilization in Females With Glenoid Bone Loss
Clinical Outcomes of Shoulder Stabilization in Females With Glenoid Bone Loss Open
Background: Nearly all studies describing shoulder stabilization focus on male patients. Little is known regarding the clinical outcomes of female patients undergoing shoulder stabilization, and even less is understood about females with g…
View article: Critical Involvement of TFIIB in Viral Pathogenesis
Critical Involvement of TFIIB in Viral Pathogenesis Open
Viral infections and the harm they cause to their host are a perpetual threat to living organisms. Pathogenesis and subsequent spread of infection requires replication of the viral genome and expression of structural and non-structural pro…
View article: Specialty-Specific Diagnoses in Pediatric Patients With Postconcussion Syndrome: Experience From a Multidisciplinary Concussion Clinic
Specialty-Specific Diagnoses in Pediatric Patients With Postconcussion Syndrome: Experience From a Multidisciplinary Concussion Clinic Open
Objective: To describe the collaborative findings across a broad array of subspecialties in children and adolescents with postconcussion syndrome (PCS) in a pediatric multidisciplinary concussion clinic (MDCC) setting. Design: Retrospectiv…