John P. Hanrahan
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View article: Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease
Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease Open
View article: Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease
Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease Open
Severely impaired mucociliary airway function is the primary pathomechanism in Cystic Fibrosis (CF) lung disease. Despite significant advances in CF therapy, there is still a critical need for alternative, individualized treatment options,…
View article: Understanding the Importance of the Lignin–Biopolymer Ratio in Optimizing the Performance of Sustainable Biomass-Derived Electrospun Carbon Fiber Anodes in Sodium-Ion Batteries
Understanding the Importance of the Lignin–Biopolymer Ratio in Optimizing the Performance of Sustainable Biomass-Derived Electrospun Carbon Fiber Anodes in Sodium-Ion Batteries Open
View article: Nano-scale viscometry reveals an inherent mucus defect in cystic fibrosis
Nano-scale viscometry reveals an inherent mucus defect in cystic fibrosis Open
Abnormally viscous and thick mucus is a hallmark of cystic fibrosis (CF). How the genetic defect causes abnormal mucus in CF remains unanswered and a question of paramount interest. Mucus is produced by hydration of gel-forming mucin macro…
View article: Effect of Selenium Nanoparticle Size on IL-6 Detection Sensitivity in a Lateral Flow Device
Effect of Selenium Nanoparticle Size on IL-6 Detection Sensitivity in a Lateral Flow Device Open
Sepsis is the body's response to an infection. Existing diagnostic testing equipment is not available in primary care settings and requires long waiting times. Lateral flow devices (LFDs) could be employed in point-of-care (POC) settings f…
View article: The Anti-Obesity Effect of Porous Silica Is Dependent on Pore Nanostructure, Particle Size, and Surface Chemistry in an In Vitro Digestion Model
The Anti-Obesity Effect of Porous Silica Is Dependent on Pore Nanostructure, Particle Size, and Surface Chemistry in an In Vitro Digestion Model Open
The potential for porous silica to serve as an effective anti-obesity agent has received growing attention in recent years. However, neither the exact pharmacological mechanism nor the fundamental physicochemical properties of porous silic…
View article: Analytical method validation for assay determination of cannabidiol and tetrahydrocannabinol in hemp oil infused products by RP-HPLC
Analytical method validation for assay determination of cannabidiol and tetrahydrocannabinol in hemp oil infused products by RP-HPLC Open
View article: Analytical method validation for assay determination of cannabidiol and tetrahydrocannabinol in hemp oil infused products by RP-HPLC
Analytical method validation for assay determination of cannabidiol and tetrahydrocannabinol in hemp oil infused products by RP-HPLC Open
A simple quantitative reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for assay determination of cannabidiol and tetrahydrocannabinol in hemp oil infused products. The RP-HPLC method …
View article: Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease
Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease Open
Background and objectives Impaired nitric oxide signaling through soluble guanylate cyclase has been implicated in the pathophysiology of diabetic kidney disease. Praliciguat, a soluble guanylate cyclase stimulator that amplifies nitric ox…
View article: An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension
An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension Open
Aims/hypothesis Praliciguat (IW-1973), a soluble guanylate cyclase stimulator, amplifies nitric oxide signalling. This exploratory trial investigated the safety, tolerability, pharmacokinetic profile and pharmacodynamic effects of pralicig…
View article: Pseudomorphic transformation and post synthetic modification of amorphous silica for CO2 sorption applications
Pseudomorphic transformation and post synthetic modification of amorphous silica for CO2 sorption applications Open
View article: Issue Information
Issue Information Open
guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our efforts.
View article: The effect of fresh gas flow during induction of anaesthesia on sevoflurane usage: a quality improvement study
The effect of fresh gas flow during induction of anaesthesia on sevoflurane usage: a quality improvement study Open
Summary Reducing fresh gas flow during inhalational anaesthesia results in cost savings and decreases environmental impact. We are interested in the influence of fresh gas flow on the early (induction) phase of overall fresh gas flow and v…
View article: A Randomized, Placebo‐Controlled, Multiple‐Ascending‐Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyclase Stimulator Praliciguat in Healthy Subjects
A Randomized, Placebo‐Controlled, Multiple‐Ascending‐Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyclase Stimulator Praliciguat in Healthy Subjects Open
Nitric oxide (NO)‐soluble guanylate cyclase (sGC)‐cyclic guanosine monophosphate (cGMP) signaling is central to the regulation of several physiological processes, including blood flow and inflammation. Deficient NO signaling is implicated …
View article: Enhancing the dissolution of phenylbutazone using Syloid® based mesoporous silicas for oral equine applications
Enhancing the dissolution of phenylbutazone using Syloid® based mesoporous silicas for oral equine applications Open
View article: Trends, over 14 years, in the ground cover on an unimproved western hill grazed by sheep, and associated trends in animal performance
Trends, over 14 years, in the ground cover on an unimproved western hill grazed by sheep, and associated trends in animal performance Open
The frequency of individual plant species at ground level and the species composition of the unimproved vegetation on a western hill farm, stocked with Scottish Blackface sheep, were monitored from 1995 to 2008. Performance criteria of the…
View article: Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial
Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial Open
ClinicalTrials.gov: NCT01690949. Registered 12 September 2012.
View article: Additional file 4: Table S2. of Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial
Additional file 4: Table S2. of Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial Open
White blood cells. (DOCX 16 kb)