John P. Hoffman
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View article: Meta Audiobox Aesthetics: Unified Automatic Quality Assessment for Speech, Music, and Sound
Meta Audiobox Aesthetics: Unified Automatic Quality Assessment for Speech, Music, and Sound Open
The quantification of audio aesthetics remains a complex challenge in audio processing, primarily due to its subjective nature, which is influenced by human perception and cultural context. Traditional methods often depend on human listene…
View article: Joint speech and text machine translation for up to 100 languages
Joint speech and text machine translation for up to 100 languages Open
Creating the Babel Fish, a tool that helps individuals translate speech between any two languages, requires advanced technological innovation and linguistic expertise. Although conventional speech-to-speech translation systems composed of …
View article: Revisiting Reliability in Large-Scale Machine Learning Research Clusters
Revisiting Reliability in Large-Scale Machine Learning Research Clusters Open
Reliability is a fundamental challenge in operating large-scale machine learning (ML) infrastructures, particularly as the scale of ML models and training clusters continues to grow. Despite decades of research on infrastructure failures, …
View article: Movie Gen: A Cast of Media Foundation Models
Movie Gen: A Cast of Media Foundation Models Open
We present Movie Gen, a cast of foundation models that generates high-quality, 1080p HD videos with different aspect ratios and synchronized audio. We also show additional capabilities such as precise instruction-based video editing and ge…
View article: Seamless: Multilingual Expressive and Streaming Speech Translation
Seamless: Multilingual Expressive and Streaming Speech Translation Open
Large-scale automatic speech translation systems today lack key features that help machine-mediated communication feel seamless when compared to human-to-human dialogue. In this work, we introduce a family of models that enable end-to-end …
View article: SeamlessM4T: Massively Multilingual & Multimodal Machine Translation
SeamlessM4T: Massively Multilingual & Multimodal Machine Translation Open
What does it take to create the Babel Fish, a tool that can help individuals translate speech between any two languages? While recent breakthroughs in text-based models have pushed machine translation coverage beyond 200 languages, unified…
View article: Figure S6 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S6 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental data for Figure 4.
View article: Figure S3 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S3 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure 3. Testing screen hits in patient-derived xenografts.
View article: Figure S5 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S5 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure 5. Quantified protein expression in PDAC 001 cells.
View article: Figure S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure S1. Rapid derivation of PDAC cells in culture
View article: Tables S1 and S3 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Tables S1 and S3 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Table S1. Genetic characterization of patient-derived xenografts using the Illumina Trusight panel capturing frequent mutations in 94 genes and 284 SNPs associated with cancer Table S3. Triptolide-induced effects on the mRNA abundance was …
View article: Tables S1 and S3 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Tables S1 and S3 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Table S1. Genetic characterization of patient-derived xenografts using the Illumina Trusight panel capturing frequent mutations in 94 genes and 284 SNPs associated with cancer Table S3. Triptolide-induced effects on the mRNA abundance was …
View article: Table S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Table S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
AUC results of the drug sensitivity screens in conditionally reprogrammed PDAC cells.
View article: Figure S2 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S2 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure 2. Rapid derivation of PDAC cells in culture.
View article: Figure S2 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S2 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure 2. Rapid derivation of PDAC cells in culture.
View article: Figure S7 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S7 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
ERCC3 interacting proteins.
View article: Figure S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure S1. Rapid derivation of PDAC cells in culture
View article: Figure S3 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S3 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure 3. Testing screen hits in patient-derived xenografts.
View article: Figure S7 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S7 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
ERCC3 interacting proteins.
View article: Table S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Table S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
AUC results of the drug sensitivity screens in conditionally reprogrammed PDAC cells.
View article: Figure S6 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S6 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental data for Figure 4.
View article: Figure S5 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S5 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure 5. Quantified protein expression in PDAC 001 cells.
View article: Data from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Data from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Purpose: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the tumors of individual patients.E…
View article: Figure S4 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S4 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure 4. mRNA abundance in triptolide-treated PDAC 001 cells
View article: Data from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Data from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Purpose: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the tumors of individual patients.E…
View article: Figure S4 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Figure S4 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer Open
Supplemental Figure 4. mRNA abundance in triptolide-treated PDAC 001 cells
View article: Proceedings of the First Workshop on Cross-Cultural Considerations in NLP (C3NLP)
Proceedings of the First Workshop on Cross-Cultural Considerations in NLP (C3NLP) Open
This paper investigates the performance of massively multilingual neural machine translation (NMT) systems in translating Yorùbá greetings (ε kú 1 ), which are a big part of Yorùbá language and culture, into English.To evaluate these mode…
View article: No Language Left Behind: Scaling Human-Centered Machine Translation
No Language Left Behind: Scaling Human-Centered Machine Translation Open
Driven by the goal of eradicating language barriers on a global scale, machine translation has solidified itself as a key focus of artificial intelligence research today. However, such efforts have coalesced around a small subset of langua…