John Paul Leach
YOU?
Author Swipe
View article: Real‐world effectiveness and tolerability of cenobamate in drug‐resistant epilepsy: A retrospective analysis of the patients included into the Early Access Programs (<scp>EAP</scp>) in Germany, France, and <scp>United Kingdom</scp>
Real‐world effectiveness and tolerability of cenobamate in drug‐resistant epilepsy: A retrospective analysis of the patients included into the Early Access Programs (<span>EAP</span>) in Germany, France, and <span>United Kingdom</span> Open
Objective Investigate real‐world outcomes in drug‐resistant epilepsy (DRE) patients treated with cenobamate as adjunctive treatment to other antiseizure medications (ASMs) within the Early Access Programs (EAP) in Germany, France, and the …
View article: Characterising people with focal drug-resistant epilepsy: A retrospective cohort study
Characterising people with focal drug-resistant epilepsy: A retrospective cohort study Open
No one ASM is optimal for all people with F-DRE, and the risks and benefits of the ASM must be considered. Comorbidities must be an integral part of the management strategy and drive the choice of drugs.
View article: The impact of the COVID-19 pandemic on a cohort of adults with epilepsy
The impact of the COVID-19 pandemic on a cohort of adults with epilepsy Open
We have shown that during a national lockdown, in the context of a pandemic, mortality in patients with epilepsy has reduced, while out-patient services were delivered remotely, primarily via the telephone. The reasons for this remain uncl…
View article: Support for COVID-19 mandatory vaccination in the United States: examining the role of cultural worldviews, risk-benefit perceptions, and trust in scientists
Support for COVID-19 mandatory vaccination in the United States: examining the role of cultural worldviews, risk-benefit perceptions, and trust in scientists Open
This study sets out to understand the role of cultural worldviews, risk perceptions, and trust in scientists in impacting U.S. participants' support for COVID-19 mandatory vaccination. Results from an online survey (“N” = 594) suggest that…
View article: Protocol for the development of an international Core Outcome Set for treatment trials in adults with epilepsy: the EPilepsy outcome Set for Effectiveness Trials Project (EPSET)
Protocol for the development of an international Core Outcome Set for treatment trials in adults with epilepsy: the EPilepsy outcome Set for Effectiveness Trials Project (EPSET) Open
View article: Latta: “A Physician Worth His Salt”—An Eclectic View of Thomas Aitchison Latta\'s True Contribution to Modern Medicine
Latta: “A Physician Worth His Salt”—An Eclectic View of Thomas Aitchison Latta\'s True Contribution to Modern Medicine Open
Sodium 1 mmol/kg/24 hour Potassium 1 mmol
View article: ‘All Out of Tune’: Is it Curtains for the Tuning Fork?
‘All Out of Tune’: Is it Curtains for the Tuning Fork? Open
View article: Delivery of care, seizure control and medication adherence in women with epilepsy during pregnancy
Delivery of care, seizure control and medication adherence in women with epilepsy during pregnancy Open
View article: Impact of regulatory safety notices on valproate prescribing and pregnancy outcome among women of child-bearing potential in Scotland: a population-based cohort study
Impact of regulatory safety notices on valproate prescribing and pregnancy outcome among women of child-bearing potential in Scotland: a population-based cohort study Open
Objective To examine the impact of Medicines and Healthcare products Regulatory Agency (MHRA) safety alerts on valproate prescribing among women aged 14–45 years in Scotland and examine trends in pregnancies exposed to valproate. Design Po…
View article: The influence of demographics and comorbidity on persistence with anti-seizure medication
The influence of demographics and comorbidity on persistence with anti-seizure medication Open
Persistence varied widely. Demographic factors, previous non-persistence and overall number of comorbidities were more important determinants of persistence to anti-seizure medications than specific individual comorbidities. Interventions …
View article: Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs
Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs Open
Background Levetiracetam (Keppra ® , UCB Pharma Ltd, Slough, UK) and zonisamide (Zonegran ® , Eisai Co. Ltd, Tokyo, Japan) are licensed as monotherapy for focal epilepsy, and levetiracetam is increasingly used as a first-line treatment for…
View article: Measuring differential attainment: a longitudinal analysis of assessment results for 1512 medical students at four Scottish medical schools
Measuring differential attainment: a longitudinal analysis of assessment results for 1512 medical students at four Scottish medical schools Open
Objective To measure Differential Attainment (DA) among Scottish medical students and to explore whether attainment gaps increase or decrease during medical school. Design A retrospective analysis of undergraduate medical student performan…
View article: Winning hearts and minds: ECG reporting in the first seizure clinic
Winning hearts and minds: ECG reporting in the first seizure clinic Open
View article: The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial Open
National Institute for Health Research Health Technology Assessment Programme.
View article: The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial Open
View article: Issue Information
Issue Information Open
View article: Issue Information
Issue Information Open
View article: Issue Information
Issue Information Open
View article: Viva la VOSCE?
Viva la VOSCE? Open
Background The COVID-19 pandemic lockdown precluded face-to-face final Objective Structured Clinical Examinations (OSCE) in the UK. Results In response, we rapidly developed and then successfully implemented a novel Virtual Objective Struc…
View article: Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II)
Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II) Open
Introduction Antiepileptic drugs (AEDs) are the mainstay of epilepsy treatment. Over the past 20 years, a number of new drugs have been approved for National Health Service (NHS) use on the basis of information from short-term trials that …
View article: Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures: Second interim analysis of 6-month data from a prospective observational study in Europe
Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures: Second interim analysis of 6-month data from a prospective observational study in Europe Open
Brivaracetam (BRV) is indicated for adjunctive treatment of focal (partial-onset) seizures with or without secondary generalisation in patients 4 years of age and older in the European Union (EU). An ongoing 12-month, prospective, non-inte…
View article: Hiding in Plain Sight: Functional Neurological Disorders in the News
Hiding in Plain Sight: Functional Neurological Disorders in the News Open
Functional neurological disorders are often wrongly considered a rare medical curiosity of the past. However, these findings suggest that, while they are largely absent from public discourse, they often appear in the news incognito, hiding…
View article: Refractory status epilepticus in adults admitted to ITU in Glasgow 1995–2013 a longitudinal audit highlighting the need for action for provoked and unprovoked status epilepticus
Refractory status epilepticus in adults admitted to ITU in Glasgow 1995–2013 a longitudinal audit highlighting the need for action for provoked and unprovoked status epilepticus Open
View article: Treatment of epilepsy – towards precision
Treatment of epilepsy – towards precision Open
Epilepsy was among the first disease areas to begin to apply principles of precision medicine to its treatment. This review looks at the role of investigation in ensuring the safety and effectiveness of antiepileptic drug treatment. Using …
View article: Faculty Opinions recommendation of Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients.
Faculty Opinions recommendation of Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients. Open
The HLA-B * 15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN) in Thai patients.The HLA-B alleles associated with carbamazepine-induced macu…
View article: Hypothesis: Multiple Sclerosis is caused by a sequential double hit of two common infections.
Hypothesis: Multiple Sclerosis is caused by a sequential double hit of two common infections. Open
View article: Brainstem encephalitis and acute polyneuropathy associated with hepatitis E infection
Brainstem encephalitis and acute polyneuropathy associated with hepatitis E infection Open
A 59-year-old man presented with feverish illness. His Glasgow Coma Scale was 15, had reduced visual acuity in the left eye with partial left ptosis and mild left hemiparesis with an extensor left plantar. Over 48 hours, he accrued multipl…
View article: Epilepsy and Pregnancy: For healthy pregnancies and happy outcomes. Suggestions for service improvements from the Multispecialty UK Epilepsy Mortality Group
Epilepsy and Pregnancy: For healthy pregnancies and happy outcomes. Suggestions for service improvements from the Multispecialty UK Epilepsy Mortality Group Open
Between 2009 and 2012 there were 26 epilepsy-related deaths in the UK of women who were pregnant or in the first post-partum year. The number of pregnancy-related deaths in women with epilepsy (WWE) has been increasing. Expert assessment s…
View article: After sudden unexpected death in epilepsy: Lessons learned and the road forward
After sudden unexpected death in epilepsy: Lessons learned and the road forward Open
Summary The devastating effects of sudden unexpected death in epilepsy ( SUDEP ) can be difficult to navigate, even for experienced clinicians. Mounting evidence supports full disclosure of the risks of epilepsy to those affected and their…